I'm just posting this for reference rather then "opening a can of worms". There are a lot of holes in this from what I can see. For example long term use, timing, limited sample size, etc. Interesting either way...
Clin Nutr. 2007 Jan 30; : 17270317 (P,S,E,B,D)
Fish oil supplementation does not alter energy efficiency in healthy males.
[My paper] Murielle Bortolotti, Luc Tappy, Philippe Schneiter
Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland.
BACKGROUND AND AIMS: Fish oil (FO) supplementation prevents the development of obesity and insulin resistance, and upregulate the expression of UCP3 in skeletal muscle in rodents. This may represent indirect evidence that FO promotes fat oxidation and/or alter energy efficiency. The aim of this study was to evaluate whether such effects can be observed in humans. The metabolic effects of FO were assessed during exercise in order to obtain a direct measurement of energy efficiency. METHODS: Eight healthy male volunteers were studied with and without supplementation with 7.2g/day FO (including 1.1g/day eicosopentaenoic acid and 0.7g/day decosahexaenoic acid) during 14 days. Their VO(2max) was measured on cycle ergometer. Thereafter, energy metabolism (substrate oxidation, energy expenditure and energy efficiency) was assessed during a 30min cycling exercise at 50% VO(2max) performed 2h30 after a standardized, high carbohydrate breakfast. RESULTS: VO(2max) was 38.6+/-2.2 after FO and 38.4+/-2.0 (mLxkg(-1)xmin(-1)) in control conditions (NS). Basal plasma glucose, insulin and NEFA concentrations, and energy metabolism were similar with FO and in controls. During exercise, the increases in plasma NEFA concentrations, energy expenditure, glucose and lipid oxidation, and the decreases in glycaemia and insulinemia were not altered by FO intake. Energy efficiency was 22.4+/-0.6% after FO vs 21.8+/-0.7% in controls. In order to ascertain that the absence of effects of FO was not due to consumption of a carbohydrate meal immediately before exercise, 4 of the 8 subjects were re-studied in fasting conditions, FO also failed to alter energy efficiency in this subset of studies. CONCLUSION: FO supplementation did not significantly alter energy metabolism and energy efficiency during exercise in healthy humans.