Excitotoxins are chemicals that stimulate the neurons in the brain to excessive firing, and can possibly cause brain damage.
an examples of excitotoxins are aspertame and msg.
Yes,but the abstract below paints fursultiamine as preferable but I suppose similiar results could have been seen with a different B vitamin analogue/thiamine.
This person is not elderly and was only eating one meal per day most likely.This was likely a hefty caloric deficit for an extended period of time.So this has a bit of crossover reference to dieting athletes.
So if you diet and train intensively and/or take in stimulants on a regular basis,I think it would be wise to at least have fursultiamine on hand,I'm not sure about using it regularly though.
Bottom line being that anyone who takes stimulants should take in a multivitamin with extra B vitamins,make sure there is a high thiamine content)I have to do more research on thiamine analogues to really come to a conclusion on them.
FWIW,I recently gave my mother a bottle of NP's bulk sulbutiamine to help her with energy levels as she drinks too much coffee.A couple months before this I gave her a few of CN's sulbutiamine caps and she loged the effects,clear energy without sleep disturbance,unlike coffeee/caffiene.So I'm not overly concerned with her using sulbutiamine for a couple months but I'm definitely going to research it thoroughly before I suggest that she buy more once she gets through the 30 grams I gave her.
Kokyu To Junkan. 1991 Jan;39(1):89-94.Links
[A case of beriberi heart--with special reference to the rapid effect of fursultiamine on hemodynamics]
[Article in Japanese]
Oimatsu H, Okada T, Sawai K, Satoh R, Mukai H, Kudoh C.
Department of Cardiology, Kushiro City General Hospital.
A 33-year-old man was admitted to Kushiro City General Hospital on February 27, 1989, because of palpitation, shortness of breath and anasarca. Eight months previously he had noted the onset of pretibial edema, which had progressed to anasarca. He had had a meal only once a day for nine months. Physical examination revealed a blood pressure of 114/46 mmHg and pulse rate of 80/min. The 3rd sound was audible. No rales in the chest and no hepatosplenomegaly were noted. Ascites, pretibial edema and anasarca were present. Vibration sensation was diminished, and the deep tendon reflexes were absent in the legs. The blood thiamine level on the 4th day of hospitalization decreased to 2.9 micrograms/dl. The red cell transketolase activity and TPP effect on the 10th hospital day were 0.76 IU/gHb and 11%, respectively. A chest roentogenogram showed pulmonary congestion and cardiomegaly (CTR 61.3%). The electrocardiogram showed non-specific T wave changes. On the echocardiogram, remarkable pericardial effusion and diffuse hypertrophy of the left ventricular wall were observed. In addition, the left ventricular wall motion showed a hyperkinetic state. On the basis of these findings, the diagnosis of beriberi heart was made. The hemodynamic study performed on the 10th hospital day showed a remarkable high cardiac output (CO) of 10.7 l/min and an extremely reduced total peripheral resistance (TPR) of 352 dynes.sec.cm-5. 15 min after intravenous administration of Fursultiamine 100 mg, CO decreased to 7.24 l/min and TPR increased to 848 dynes.sec.cm-5. Following the administration of Fursultiamine 75 mg, po/day, his symptoms and abnormal findings of clinical examination data rapidly improved.(ABSTRACT TRUNCATED AT 250 WORDS)
Colin, what dose did your mother have?
I use Adam, a multi from NOW Foods. I might just add a 300mg cap of Sulbutiamine to that as i am dieting and using stims atm.
As long as your multi has more than 100% RDA for thiamine the sulbutiamine may be redundant.You could head over to Pubmed.com and research this yourself with sulbtiamine beriberi heart, fursultiamine beriberi heart and/or thiamine beriberi heart as the search terms.
I don't see myself having the time to do this research intil I absolutely have to e.g. when my mom runs out of her current sulbutiamine supply.
I'm content with thiamine supplementation through my multi,a Centrum Performance generic knockoff,at least for now.
I just looked into fursultiamine and the same potential issue (neurotoxicity) is applicable to it.I came across a positive abstract for thiamine supplementation though,while another abstact (which I posted above) showed no signifigantly positive effects WRT sulbutiamine.I'm not all that convinced fursultiamine is worth sourcing either.
Thiamine's bioavailability is much less than its analogues so a decent dose should be all that's needed.If you wind up in an ER though,I'd ask for some fursultiamine.
I use more stims than I should,in conjunction with bezafibrate (which are primarily oxidized in the heart) if I overeat and DNP while dieting.I am satisfied with a heart protective stack of COq10,hawthorn berry and fish oil along with thiamine.I do like AMPV.2 (with fursultiamine) but no longer think that fursultiamine is a staple for tweakers.But it woul;dn;t hurt to have some on hand in case of an intense heart pain flareup.
: Metab Brain Dis. 1996 Mar;11(1):95-106.Links
Effects of thiamine supplementation on exercise-induced fatigue.
Suzuki M, Itokawa Y.
Institute of Health & Sports Sciences, University of Tsukuba, Japan.
High-dose thiamine (vitamin B1) supplementation (100 mg/day) may be helpful in preventing or accelerating recovery from exercise-induced fatigue. Sixteen volunteer male athletes volunteer, 8 with a blood thiamine level of 40 ng/ml or more (normal thiamine group) and 8 with levels below that level (low thiamine group) were selected as subjects. They exercised on a bicycle ergometer and the effects of thiamine supplementation were compared with placebo. Blood thiamine level markedly increased following supplementation of thiamine for 3 days before exercise. Exercise-induced changes in hemodynamic parameters and cardiopulmonary function indicated the onset of fatigue. Thiamine supplementation significantly suppressed the increase in blood glucose in the normal thiamine group and significantly decreased the number of complaints shortly after exercise in the subjective fatigue assessment of 30 items.
I got these from the Inncer Circle's full text request thread over on M&M:
Is_there_a_role_for_thiamine_s upplementation_in_the_manageme nt_of_heart_failure__.pdf
Neither study comes to much of a conclusion though so if you are a heavy stim user with extra money and suspect or know that you have a history of family heart trouble,fursultiamine would be a good play.
I would buy fursultiamine if NutraPlanet sold it. Here is a problem with sulbutiamine (Replace characters // and . cause I don't exactly have 50 posts yet and can't post links):
I'm going to go ahead and bump this, even though it's old. SAN Launch ingredients:
Maybe Nutra can pick it up?
I passed on a reminder for you poison. Sorry I never replied to your PM bud.
Ill buy it for damn sure!
Thanks, man, much appreciated!
Seriously, schizm. It's nuts that they don't carry Launch 4350/Launch, Green Supreme Fusion, Cultivate, Intra Fuel, CM2, etc.