11-Hydoxy-Yohimbine?

[Skigazzi]

Lets go Dsade...chop chop:

Le Corre P, Dollo G, Chevanne F, Le Verge R.

Laboratoire de Pharmacie Galénique, Biopharmacie et Pharmacie Clinique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes 1, 35043, Rennes, France. pascal.le-corre@univ-rennes1.fr

The biopharmaceutics of yohimbine (YO) and the pharmacokinetics of 10-hydroxy-yohimbine (10-OH-YO) and 11-hydroxy-yohimbine (11-OH-YO) were investigated in healthy subjects following i.v. (5 mg) and oral (8 mg) dosing. One subject was found as a slow hydroxylator of YO. The mean (+/-S.D.) oral absolute bioavailability of YO was 22.3+/-21. 5%. Total plasma clearance (CL) and renal clearance (CL®) of YO following i.v. dosing were 0.728+/-0.256 ml/min and 0.001+/-0.002 ml/min, respectively. Based on the steady-state volume of distribution (V(ss)), YO had a relatively low distribution (V(ss) = 32.2+/-12.1 l). The overall renal excretion of YO, 10-OH-YO and 11-OH-YO, expressed as percent of the dose of YO administered, were not different following i.v. and oral dosing, and were around 0.1, 0.2 and 14%, respectively. Following i.v. dosing of YO, the mean apparent terminal half-life of 11-OH-YO (347+/-63 min) was almost four times higher than that of YO (91.0+/-33.6 min) suggesting an elimination rate-limited kinetics for 11-OH-YO.

PMID: 10494000 [PubMed - indexed for MEDLINE]

[dsade]

What about receptor affinities?

[Skigazzi]

Um....Ummmm....



(NxLabs is using this in a fatburner, they are sending me a sample, so I'll at least report anecdotal feedback on it)

[Cool]

Looks good. I think Y3 has this, is that the Nxlabs? I was excited to try Y3 then saw average and less than average reviews. Maybe you'll do better. Good luck!

[dsade]

Um....Ummmm....



(NxLabs is using this in a fatburner, they are sending me a sample, so I'll at least report anecdotal feedback on it)

I think I have a samples bottle of this sitting around. I usually get pretty harsh side effects from standard YHCl, so I might give this a shot.

[bioman]

It would be nice if the hydroxy YO had less of a crash. I built up a decent tolerance to regular yohimbine but when I stopped taking it..I felt like a lukewarm corpse.

But I did burn off about 4 pounds of goo.

[dsade]

It would be nice if the hydroxy YO had less of a crash. I built up a decent tolerance to regular yohimbine but when I stopped taking it..I felt like a lukewarm corpse.

But I did burn off about 4 pounds of goo.

Did you ever try Avant's HEAT with the Alpha-Yohimbine? No crash at all.

[bioman]

Nope, haven't tried it. I'm more of a NP bulk supp kinda guy..if'n you know what I mean.

[dsade]

Nope, haven't tried it. I'm more of a NP bulk supp kinda guy..if'n you know what I mean.

I do...and we should have you covered.

[bioman]

Awesome.