Protracted action of protein anabolism in gynecological oncology and its effect on hepatic function. Dambrosio, F.; Donatelli, G. Fontana. Univ. Milan, Cancro, Il (1963), 16(5), 553-604. Journal language unavailable. CAN 62:11656 AN 1965:11656 CAPLUS
Abstract
Twenty mg. of dimetazine, an anabolizing steroid, was administered daily for 45-95 days to 11 gynecological patients. More than 50% of the cases showed no change in the bilirubinemia, the others showed modest to moderate increases. The glutamic-oxalacetic and the glutamic-pyruvic transaminases of the serum increased greatly in 3 patients. The albumins concn. usually decreased in the course of the treatment, while the globulins concn. did not change.
A new steroid with protein anabolic activity: dimethazine. De Ruggieri, P.; Matscher, R.; Gandolfi, C.; Chiaramonti, D.; Lupo, C.; Pietra, E.; Cavalli, R. Ormonoterap. Richter, Milan, Archivio di Scienze Biologiche (Bologna) (1963), 47(1), 1-19. CODEN: ASBIAL ISSN: 0004-0169. Journal language unavailable. CAN 60:46973 AN 1964:46973 CAPLUS
Abstract
Dimethazine (I) was evaluated for the following biol. activities: androgenic, N retaining, P retaining, and Ca retaining. The increase in uptake of -aminoisobutyric acid-1-14C and the increase in body wt. were also investigated. Data obtained, tabulated, and compared to those obtained with methyltestosterone established that I is a protein anabolic steroid with weak androgenic activity.
No progestenic/estrogenic activity...so this would differentiate it from its chemical relative oxymetholone (anadrol)
Biological determination of the secondary hormonal activities of dimethazine. Lupo, C.; Matscher, R.; Ruggieri, P. De. Lab. Ric. Ormonoter. Richter, Milan., Bollettino - Societa Italiana di Biologia Sperimentale (1962), 38 990-4. CODEN: BSIBAC ISSN: 0037-8771. Journal language unavailable. CAN 58:34624 AN 1963:34624 CAPLUS
Abstract
Expts. with rats and rabbits showed that dimethazine, 2,17-dimethyl-5-androstan-17-ol-3,3'-azine has, in contrast to its protein-anabolic properties, practically no estrogenic, progestational, and corticoid activity. Similarly, it has no effect on liver glycogen, and no antiinflammatory action on the anaphylactoid edema.
Comparisons with methyltest, winny, anadrol and test prop showed better mytropic effect on the castrates with methylmasteron.
Biological activity of dimethazine in the protein-anabolic field. Matscher, R.; Lupo, C.; De, P. Ruggieri. Lab. Ric. Ormonoter. Richter, Milan, Bollettino - Societa Italiana di Biologia Sperimentale (1962), 38 988-90. CODEN: BSIBAC ISSN: 0037-8771. Journal language unavailable. CAN 58:34623 AN 1963:34623 CAPLUS
Abstract
Dimethazine (I), 2,17-dimethyl-5-androstan-17-ol-3,3'-azine, was compared to methyltestosterone, oxymethalone, androstanazole and testosterone propionate in its protein-anabolic activity. The tests were made on castrated rats with a single hypodermic injection of 250 , on young male and female rats with increasing daily oral doses from 100 to 1000 for 30 days, and on adult male rats with daily oral doses of 1000 for 25 days. It was shown that I did not interfere with the growth of young animals; that adult rats treated with I gained, on an av., 20 g. more in wt. than the controls; and that I had a greater myotropic effect on castrates than the other steroids, and induced a higher N retention than methyltestosterone in adult males.
