Stem Cell Injections Worked Remarkably Well at Easing Symptoms of Muscular Dystrophy

  1. New Member
    Oswizle's Avatar
    Join Date
    Aug 2006
    Posts
    106
    Rep Power
    252
    Level
    10
    Lv. Percent
    3.49%

    Stem Cell Injections Worked Remarkably Well at Easing Symptoms of Muscular Dystrophy


    [ NEW YORK -- Stem Cell Injections Worked Remarkably Well at Easing Symptoms of Muscular Dystrophy i
    Nov 16, 03:46 PM


    By Malcolm Ritter THE ASSOCIATED PRESS

    NEW YORK -- Stem cell injections worked remarkably well at easing symptoms of muscular dystrophy in a group of golden retrievers, a result that experts call a significant step toward treating people.

    "It's a great breakthrough for all of us working on stem cells for muscular dystrophy," said researcher Johnny Huard of the University of Pittsburgh, who wasn't involved in the work.

    Sharon Hesterlee, vice president of translational research at the Muscular Dystrophy Association, called the result one of the most exciting she's seen in her eight years with the organization. Her organization helped pay for the work.

    She stressed that it's not yet clear whether such a treatment would work in people but said she had "cautious optimism" about it.

    Two dogs that were severely disabled by the disease were able to walk faster and even jump after the treatments.

    The study was published online Wednesday by the journal Nature. It used stem cells taken from the affected dogs or other dogs, rather than from embryos. For human use, the idea of using such "adult" stem cells from humans would avoid the controversial method of destroying human embryos to obtain stem cells.

    The Nature paper focuses on Duchenne muscular dystrophy, a muscle- wasting genetic disorder that affects only boys and occurs in about 1 in every 3,500 male births. It's the most severe and most common childhood form of muscular dystrophy and the best-known. In theory, the stem cell treatment might also help other muscle dystrophies or even age-related muscle wasting, Hesterlee said.

    Boys with Duchenne dystrophy have trouble walking as early as preschool, and nearly all of them lose their ability to walk between ages 7 and 12. Typically, they die in their 20s. There is no known cure.

    The dog study was done by Giulio Cossu, director of the Stem Cell Research Institute at the San Raffaele Scientific Institute of Milan in Italy, with colleagues there and elsewhere.

    "We do not know whether this will work in patients," Cossu said in a telephone interview. He said he hopes to start a small experiment in children in the next year or two.

    The scientists worked with golden retrievers that suffer a crippling form of dystrophy very much like the human one. Researchers studied the effect of repeated injections into the bloodstream of a kind of stem cell extracted from blood vessel walls.

    The best results appeared when the cells were taken from healthy dogs. But Cossu said scientists should pursue the possibility of genetically manipulating a patient's own cells and using them instead. That way, patients wouldn't have to undergo lifelong treatment to avoid rejection of donated cells.

    In one of several experiments, three dogs that had not yet shown impairment in walking were injected five times, a month apart, with cells taken from other dogs.

    One dog completely avoided symptoms and continued to walk well even five months after both the injections and the anti-rejection therapy were stopped.

    A second dog also did well initially but died suddenly of a heart problem after just two months on the treatment. It's not clear whether the problem had anything to do with the treatment, Cossu said.

    The third dog showed partial protection, being able to walk and even run with a limp, but then progressively lost walking ability within a few days after the anti-rejection treatment was stopped. The researchers also treated two dogs that were severely impaired by the disease. Both gained the ability to move much faster and to jump, and one was even able to run, although neither could use the hind legs normally.

    One of these dogs rapidly lost walking ability when the anti- rejection treatment was stopped, but the other continued to walk well for five months until succumbing to pneumonia.

    Cossu said he believed that a human treatment could be directed more at breathing muscles than it was in the dogs.

    The cells helped strengthen muscle by fusing with regenerating muscle fibers.

    (c) 2006 Daily Breeze. Provided by ProQuest Information and Learning. All rights Reserved.

    IN HEALTH
    Health Home

  2. New Member
    monsterboy's Avatar
    Join Date
    Nov 2006
    Posts
    36
    Rep Power
    117
    Level
    5
    Lv. Percent
    55.98%

    Looks really promising. Too bad our government won't spend any money on funding these type of studies.
  3. New Member
    baxter32's Avatar
    Join Date
    May 2006
    Posts
    23
    Rep Power
    116
    Level
    4
    Lv. Percent
    40.82%

    I second that. A little money spent on stem cells could go a long way in helping a lot of people.
    •   
       

  4. Registered User
    RedwolfWV's Avatar
    Stats
    5'10"  185 lbs.
    Join Date
    Dec 2005
    Age
    51
    Posts
    3,258
    Rep Power
    1989
    Level
    40
    Lv. Percent
    33.67%
    Achievements Activity ProPosting Pro

    Why should the government fund it?? There is plenty of money in the private sector to do this. With government money (read that, with OUR TAXDOLLARS) come rules and regulations.

    Keep the government out of things. They are into way too many things as it is. If there is money to be made, the private sector will be more than happy to spend money to develop new stuff.

Similar Forum Threads

  1. Replies: 18
    Last Post: 12-07-2007, 10:42 AM
  2. Muscle Stem Cells Transformed Into Cartilage
    By LakeMountD in forum News and Articles
    Replies: 0
    Last Post: 01-31-2006, 12:34 AM
  3. Stem cells
    By Jeff in forum Politics
    Replies: 33
    Last Post: 10-15-2004, 05:37 PM
  4. hcg worked very well
    By WATERLOGGED in forum Anabolics
    Replies: 7
    Last Post: 06-17-2004, 02:05 PM
  5. Replies: 0
    Last Post: 03-19-2004, 02:40 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in