Ibuprofen Inhibits Skeletal Muscle Hypertrophy?

[wastedwhiteboy2]

Entrez PubMed

In summary, University of Florida researchers simulated weight training with rats and then gave them ibuprofen; which may have eased their pain but resulted in a decrease in muscle mass of 20 percent after 2 weeks. Ibuprofen blocks the action of the enzyme cyclooxygenase (COX). This enzyme causes pain and soreness, but also contributes to muscle growth.

Lesson learned is that pain killers may inhibit muscle growth. In other words: No Pain, No Gain.

what do you guys think?

 

[bioman]

This has been known..or at least suspected for quite some time. Since Ibu inhibits COx it shuts down a long chain of prostaglandin related reactions. Some of these prostaglandins are responsible for pain and inflammation, but many more are responsible for growth and repair of not only muscle, but tendons, joints and ligaments as well. It's been noted that in long term Ibu users, joint degredation is increased.

Newer Cox inhibitors on the horizon will be more nuanced and attack only the pain and inflammation portions of the signal cascade...like Cissus for example. In any case, there are other healthier options than Ibu out there for inflammation control.

And no, I don't believe one has to be in chronic pain to gain.

 

[wastedwhiteboy2]

thanks for your thoughts.