Ibuprofen Inhibits Skeletal Muscle Hypertrophy? - AnabolicMinds.com

Ibuprofen Inhibits Skeletal Muscle Hypertrophy?

  1. Board Supporter
    wastedwhiteboy2's Avatar
    Stats
    6'0"  195 lbs.
    Join Date
    Jun 2004
    Age
    40
    Posts
    2,987
    Rep Power
    3011

    Reputation

    Ibuprofen Inhibits Skeletal Muscle Hypertrophy?


    Entrez PubMed

    In summary, University of Florida researchers simulated weight training with rats and then gave them ibuprofen; which may have eased their pain but resulted in a decrease in muscle mass of 20 percent after 2 weeks. Ibuprofen blocks the action of the enzyme cyclooxygenase (COX). This enzyme causes pain and soreness, but also contributes to muscle growth.

    Lesson learned is that pain killers may inhibit muscle growth. In other words: No Pain, No Gain.

    what do you guys think?

  2. Elite Member
    bioman's Avatar
    Stats
    5'10"  180 lbs.
    Join Date
    Sep 2003
    Age
    42
    Posts
    7,697
    Rep Power
    513131

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    This has been known..or at least suspected for quite some time. Since Ibu inhibits COx it shuts down a long chain of prostaglandin related reactions. Some of these prostaglandins are responsible for pain and inflammation, but many more are responsible for growth and repair of not only muscle, but tendons, joints and ligaments as well. It's been noted that in long term Ibu users, joint degredation is increased.

    Newer Cox inhibitors on the horizon will be more nuanced and attack only the pain and inflammation portions of the signal cascade...like Cissus for example. In any case, there are other healthier options than Ibu out there for inflammation control.

    And no, I don't believe one has to be in chronic pain to gain.
  3. Board Supporter
    wastedwhiteboy2's Avatar
    Stats
    6'0"  195 lbs.
    Join Date
    Jun 2004
    Age
    40
    Posts
    2,987
    Rep Power
    3011

    Reputation

    thanks for your thoughts.
    •   
       

Similar Forum Threads

  1. Replies: 9
    Last Post: 12-01-2012, 10:31 AM
  2. Replies: 4
    Last Post: 12-13-2008, 01:27 PM
  3. Ibuprofen Inhibits Skeletal Muscle Hypertrophy in Rats
    By LakeMountD in forum Supplements
    Replies: 0
    Last Post: 07-16-2006, 09:24 PM
  4. Repetitions and Muscle Hypertrophy
    By Mach .78 in forum Exercise Science
    Replies: 1
    Last Post: 03-16-2006, 03:44 PM
  5. Basic Skeletal Muscle Anatomy....
    By Lifeguard in forum Exercise Science
    Replies: 5
    Last Post: 12-12-2002, 06:26 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in