Reduction of Serum Testosterone in Men by Licorice

[SHADOW2492]

New england journal of medicine has this .Does anyone have a pay membership? I can only view this extract
http://content.nejm.org/cgi/content/...urcetype=HWCIT

Reduction of Serum Testosterone in Men by Licorice


Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

the Editor: Extracts of licorice root are widely used in many countries as flavoring agents, breath fresheners, or candy. The active component of licorice is glycyrrhizic acid, which is hydrolyzed in vivo to glycyrrhetinic acid. The well-known mineralocorticoid-like effect of licorice results from the inhibition of 11ß-hydroxysteroid dehydrogenase, the enzyme that catalyzes the conversion of cortisol to cortisone, thereby minimizing the binding of cortisol to mineralocorticoid receptors.1 Licorice may also directly activate mineralocorticoid receptors.2 In vitro, licorice can block 17ß-hydroxysteroid dehydrogenase, which catalyzes the conversion of androstenedione to testosterone.3

We evaluated the effect of licorice on . . .

References


This article has been cited by other articles:

* Piersen, C. E. (2003). Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer. Integr Cancer Ther 2: 120-138 [Abstract]
* Fukui, M., Kitagawa, Y., Nakamura, N., Yoshikawa, T. (2003). Glycyrrhizin and Serum Testosterone Concentrations in Male Patients With Type 2 Diabetes. Diabetes Care 26: 2962-2962

if anyone can get the full PDF please do!

DISCUSS your thoughts here, now I am avoiding black licorice, i do not think this would apply to red but I will have to see, because I heard red licorice isnt actually licorice.

[jmh80]

This would seem to have negitive implications for Giant Nutrtion's new version of Skulpt (I forget the name) and Carlito's TargetX - both have the GA as topical cortisol reducers.

Although, if theirs is site specific - maybe this research isn't such a big deal.

[yeahright]

Bummer, I drink licorice tea on a routine basis.

[wastedwhiteboy2]

yeah, I had heard this a while back just not the why.