Relationship between reduced antioxidant status and insulin resistance state observed in nonobese children


Relationship between reduced antioxidant status and insulin resistance state observed in nonobese children.

According to recent research published in the journal Clinica Chimica Acta, "The prevalence of insulin resistance has been reported in nonobese, nondiabetic healthy individuals. We examined the relationship between insulin resistance and the reduced antioxidant systems of plasma lipid soluble vitamins and antioxidant enzymes in erythrocytes and to determine the contributing factors to the antioxidant systems in nonobese children."

M.J. Shin and colleagues at Kyungnam University explained, "We measured blood lipid profiles, glucose, insulin concentrations, plasma antioxidant vitamins and erythrocytic antioxidant enzyme activities of 103 Korean children in the absence of obesity. Insulin resistance was estimated by homeostasis model assessment of insulin resistance (HOMA-IR)."

They discovered, "A significant inverse relationships between HOMA-IR and lipid corrected beta-carotene (r=-0.233,p<0.05), alpha-tocopherol (r=-0.370,p<0.0001) were observed. In addition, increased HOMA-IR was significantly related to the decreased activities of superoxide dismutase (r=-0.226,p<0.05) and catalase (r=-0.261,p<0.05).

"Stepwise multiple linear regression analyses showed that HOMA-IR was the independent factor to determine the antioxidant status such as plasma alpha-tocopherol (beta=-0.379,p<0.0001), beta-carotene (beta=-0.243,p<0.05), SOD (beta=-0.230,p<0.05), and catalase activity (beta=-0.255,p<0.05) after adjusting percent ideal body weight, waist circumference, gender, blood lipids and leptin levels in nonobese children."

The researchers concluded, "The reduced antioxidant status in insulin resistance state even in nonobese children suggests the importance of early nutritional intervention with features of insulin resistance."

Shin and colleagues published their study in Clinica Chimica Acta (Contribution of insulin resistance to reduced antioxidant enzymes and vitamins in nonobese Korean children. Clin Chim Acta, 2006;365(1-2):200-205).

For additional information, contact E. Park, Kyungnam University, Dept. Food & Nutrition, Masan 631701, South Korea.

The publisher's contact information for the journal Clinica Chimica Acta is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.

Keywords: Masan, South Korea, Antioxidant Enzymes, Antioxidant Vitamins, Antioxidants, Beta-Carotene, Catalase, Diabetes, Diet and Nutrition, Endocrinology, Enzymology, Insulin Resistance, Lipid Profiles, Nonobese Children, Obesity. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2006, Biotech Week via

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