There is a metabolite in urine(oleyl estrone) which is a metabolite of Estrogen. Oleoyl estrone is a drug that causes weight and fat loss. Pharmacologically, the effects of oleyl estrone have in the body are "superimposable" with beta-3-andrenergic agonist agents (such as clenbuterol). This is an agent that reduces appetite, causes fat and weight loss and spares muscle, whle not inducing a side effect of fatigue or even tremors that are obviously occurs in many stimulants that are used to aid in fat loss. Animal studies have tested the product by itself (it works to the tune of about 66 percent of a beta-3-agent) and in combination with a beta-3-adrenergic drug (there is synergy) In addition, scientists have tested this drug in combination with sibutramine (Meridia) and the results is a better, more effective Meridia. It appears that oleoyl estrone (made by Manhattan Pharmacueticals) is a compound to watch and the early data demonstrates that it works great on its own and better if combined with a beta-3-adnergic agonists or medications that effect serotonin.