Fried Liver--Jerry Brainium [GREAT READ]

  1. Registered User
    kwyckemynd00's Avatar
    Stats
    5'10"   lbs.
    Join Date
    Jun 2004
    Age
    31
    Posts
    5,324
    Rep Power
    2849
    Level
    52
    Lv. Percent
    88.84%
    Achievements Activity ProPosting ProPosting Authority

    Fried Liver--Jerry Brainium [GREAT READ]


    Fried Liver

    by Jerry Brainium

    Your liver is your life. That sounds like a grandiose statement, but it’s true. The human liver is located behind the lower ribs, right below the diaphragm on the right side of the abdomen. It averages slightly more than three pounds in weight and is six inches thick. Without a functioning liver, you’d die a miserable death. Common food elements like protein would put you into a coma, since the by-products of protein metabolism, such as ammonia, would increase in the blood. In fact, many common food elements and drugs would prove fatal if you didn’t have this organ around to render them innocuous.

    The liver is a potent chemical-processing plant. It quietly performs more than 500 vital functions, including the following:

    •Manufactures bile, which is needed for complete fat absorption.

    •Converts protein, carbohydrate and fat into other elements.

    •Metabolizes drugs, including alcohol.

    •Cleanses the blood of toxins.

    •Produces blood-clotting factors, without which a minor cut could prove fatal.

    •Stores nutrients—such as fat-soluble vitamins A,D, E, and K; vitamin B12 and carbohydrate—as glycogen.

    •Maintains blood glucose levels by way of liver glycogen breakdown and release into the blood as glucose.

    •Synthesizes cholesterol and protein carriers for cholesterol in the blood.

    •Produces immune factors that protect against disease.

    That’s just a partial list. Obviously, you want to maintain proper liver function for maximum health. Many things are known to harm the liver, including excessive alcohol intake and drug use. From an athletic standpoint, certain types of anabolic steroids are frequently mentioned as having bad effects on liver function. They’re usually oral drugs that are classified as 17-alpha ankylated drugs.

    The designation “17-alpha ankylated? refers to a change made on position 17 of the basic steroid structure. Scientists developed the testosterone derivatives after noticing that orally taken testosterone is degraded in the liver in a process called first-pass metabolism. Drug developers circumvented that formidable problem by making testosterone available in an injectable form, which bypasses initial first-pass liver metabolism, and by manipulating the basic steroid chemical structure, as is the case with oral 17-alpha ankylated anabolic steroids.

    While the structural change in oral anabolic steroids did result in a far slower rate of breakdown in the liver, it also led to an inordinate buildup of such drugs in the liver. Since the injectable versions of steroids don’t build up in the liver as much as oral versions, the injectables are considered less of a problem in terms of normal liver function.

    The oral drugs adversely affect the liver through several mechanisms. For example, they interfere with the function of certain liver enzymes. Anabolic steroids are known to increase the activity of some liver enzymes while downgrading that of others. One enzyme that’s increased with oral anabolic steroid use is hepatic triglyceride lipase, which degrades high-density lipoprotein (HDL), a beneficial cholesterol carrier in the blood. A lowered HDL level is considered a risk factor for cardiovascular disease. Athletes who use oral anabolic steroids nearly always show depressed HDL levels. The buildup of 17-alpha ankylated oral anabolic steroids in the liver leads to a type of toxic or chemical hepatitis. Hepatitis, by the way, is a general word for an inflammation of the liver and can be caused by various factors, such as drug use and viruses. Oral steroids cause liver inflammation by promoting an increase in the size of liver cells, which leads to a congestion of bile flow through ducts in the liver that empty into the gallbladder, where bile is stored.

    The interference with bile flow induced by the effects of anabolic steroids on liver cells is called cholestasis. It usually occurs only in people who use higher doses of oral steroids or who use such steroids for extended periods of time. Certain oral steroids are reputed to have more potent toxic effect in the liver and to promote the liver swelling that can lead to cholestasis. They include oxymetholone (Anadrol-50) and fluoxymesterone (Halotestin), although it may be that those drugs cause problems because they’re often used in higher doses than other oral steroids. Both drugs are 17-alpha ankylated, as are most oral steroids.

    According to existing medical research, most cases of serious liver ailments due to oral anabolic steroid use have involved hospitalized patients who were given oral steroids such as Anadrol-50 to combat rare blood anemias. Many stayed on oral steroids for three or more years. The consensus of medical reviews is that certain potentially adverse liver changes do occur with athletic use—with the extent of the changes again depending on the drugs used, the doses and the length of time—but the changes regress when the athletes stop using the steroids. The liver is known to have an amazing capacity for regeneration unless it’s irrevocably damaged, a scenario that rarely occurs with short-term steroid use.

    Physicians often warn about elevated liver enzyme levels due to oral anabolic steroid use. While that could indicate an inflammation of the liver, the problem is that some of the measured liver enzymes aren’t specific to the liver and exist in other tissues. For example, two enzymes found in liver, ALT and AST, also exist in muscle. Any type of injury to muscle—including the kind that occurs with intense weight training—causes an elevation of those enzymes in the blood. A physician who’s not looking at the big picture—or measuring levels of other liver and muscle enzymes—may wrongly conclude that such liver enzyme increases are indicative of liver problems.1 Measuring enzymes such as creatine kinase and GGT would provide a more definitive picture of existing liver function, as would liver imaging tests.

    One visible early sign of liver inflammation due to oral steroid use is jaundice, which is characterized by a retention of bile in the body, leading to a yellow discoloration in the skin and whites of the eyes. Anyone using oral anabolic steroids should stop using them immediately if such symptoms occur. If you ignore the symptoms, you’re at risk for a more serious liver complication.

    Peliosis hepatis, as it’s called, consists of blood-filled cysts in the liver. It’s thought to be due to cholestasis; that is, the elevated pressure in liver tissue brought about by lack of proper bile flow in the liver leads to a breakdown of liver cells followed by the appearance of the cysts. The blood-filled cysts can rupture, leading to death. Most cases of peliosis have occurred in hospitalized patients on long-term steroid therapy, although the occurrence of peliosis isn’t dependent on dosage.

    One published instance of peliosis involved a 27-year-old bodybuilder who was using a steroid stack consisting of oxandrolone (Anavar), methandrostenolone (Dianabol), nandrolone (Durabolin) and testosterone for five weeks.2 What he took before that time wasn’t disclosed in the published report. The interesting aspect is that the drug stack he used isn’t considered highly toxic to the liver. The bodybuilder may have used more toxic oral steroids over a longer period, however, or he may have taken a drug such as Nolvadex, an estrogen blocker that few bodybuilders know can also cause peliosis if used in too high a dose for too long.

    The other serious liver disease often linked to oral anabolic steroid use is liver cancer. Reviews of liver cancer in various medical journals indicate that it’s of a more benign nature than other cancers. Simply put, the liver tumors that develop with steroid use usually regress if the person stops using the drugs. That’s not always the case, however.

  2. New Member
    Trance Boy's Avatar
    Join Date
    Mar 2005
    Age
    44
    Posts
    41
    Rep Power
    139
    Level
    6
    Lv. Percent
    11.54%

    great article!!
  3. Senior Member
    UNDERTAKER's Avatar
    Join Date
    Nov 2004
    Age
    36
    Posts
    1,162
    Rep Power
    703
    Level
    27
    Lv. Percent
    82.1%
    Achievements Posting Pro

    great read dude
    •   
       

  4. inventor of the remix
    Blown's Avatar
    Join Date
    Mar 2005
    Age
    31
    Posts
    187
    Rep Power
    212
    Level
    12
    Lv. Percent
    50.21%

    Very informative. thanks bro.
  5. Elite Member
    BigVrunga's Avatar
    Join Date
    Nov 2002
    Age
    38
    Posts
    5,063
    Rep Power
    2684
    Level
    49
    Lv. Percent
    26.85%
    Achievements Activity ProPosting ProPosting Authority

    More affirmation Im glad I never tried M1T
  6. Registered User
    Neuromancer's Avatar
    Join Date
    Feb 2004
    Age
    35
    Posts
    954
    Rep Power
    615
    Level
    24
    Lv. Percent
    79.49%

    Quote Originally Posted by BigVrunga
    More affirmation Im glad I never tried M1T
    Amen to that..
  7. New Member
    mightyconan's Avatar
    Join Date
    Apr 2005
    Age
    48
    Posts
    47
    Rep Power
    142
    Level
    10
    Lv. Percent
    0.53%

    GLAD U NEVER TRIED M1T, ARE U KIDDING ME OR WHAT. THAT ARTICLE JUST SAYS THAT NON STOP USE FOR YEARS, CAN DO LIVER DAMAGE, THE ARTICLE NEVER EVEN GOES INTO THE MANY HERBS AND SUPPLEMENTS ONE CAN TAKE TO CLEANZ THE LIVER. AND THIS OCCURS WITH BODYBUILDERS WHO TAKE HUGE STACKS OF ROIDS, NOT MERELY 30 MG OF M1T, GIVE ME A BREAK. DOING M1T OR SUPERDROL FOR A MONTH WON'T DO ANYTHING.
  8. Board Sponsor
    laz's Avatar
    Join Date
    May 2005
    Age
    31
    Posts
    47
    Rep Power
    139
    Level
    6
    Lv. Percent
    32.69%

    Another thread that states how bad nolva can be on the liver! What is a good alternative to nolva that is less stressful on the liver???
  9. Registered User
    kwyckemynd00's Avatar
    Stats
    5'10"   lbs.
    Join Date
    Jun 2004
    Age
    31
    Posts
    5,324
    Rep Power
    2849
    Level
    52
    Lv. Percent
    88.84%
    Achievements Activity ProPosting ProPosting Authority

    Quote Originally Posted by laz
    Another thread that states how bad nolva can be on the liver! What is a good alternative to nolva that is less stressful on the liver???
    The key there was high doses for extended use.

    i'd suggest NOT running it with AAS and using it for PCT as is necessary and you'd be fine.
  10. Advanced Member
    diplomats's Avatar
    Join Date
    Jun 2004
    Age
    32
    Posts
    605
    Rep Power
    430
    Level
    19
    Lv. Percent
    71.75%

    ****! i am starting to get paranoid now about my stack.
  11. Registered User
    kwyckemynd00's Avatar
    Stats
    5'10"   lbs.
    Join Date
    Jun 2004
    Age
    31
    Posts
    5,324
    Rep Power
    2849
    Level
    52
    Lv. Percent
    88.84%
    Achievements Activity ProPosting ProPosting Authority

    LOL?! For me, I got "less" parandoid when I read this.

    This article reaffirmed my current stance on the issue of AAS. Basically, K.I.S.S. + responsible use and NOT using harsh orals for years straight without a break + avoiding any unecessary supplementation (i.e. Nolva every damn day) and a few other things make AAS pretty damn safe.
  12. Elite Member
    BigVrunga's Avatar
    Join Date
    Nov 2002
    Age
    38
    Posts
    5,063
    Rep Power
    2684
    Level
    49
    Lv. Percent
    26.85%
    Achievements Activity ProPosting ProPosting Authority

    GLAD U NEVER TRIED M1T, ARE U KIDDING ME OR WHAT. THAT ARTICLE JUST SAYS THAT NON STOP USE FOR YEARS, CAN DO LIVER DAMAGE, THE ARTICLE NEVER EVEN GOES INTO THE MANY HERBS AND SUPPLEMENTS ONE CAN TAKE TO CLEANZ THE LIVER. AND THIS OCCURS WITH BODYBUILDERS WHO TAKE HUGE STACKS OF ROIDS, NOT MERELY 30 MG OF M1T, GIVE ME A BREAK. DOING M1T OR SUPERDROL FOR A MONTH WON'T DO ANYTHING.
    Bro why are you shouting? Are you stressed out? Do you need a hug?

    Simply put, the liver tumors that develop with steroid use usually regress if the person stops using the drugs. That’s not always the case, however.
    *That's* enough to make me feel glad I never tried it. In addition to the numerous blood tests that have been posted that showed how hard it was on the liver and lipid profile. In addition to jacking up blood pressure and generally making people feel like ****.

    I digress though - plenty of people made good gains on the stuff, and power to them. But I'm still glad I never tried it

    I agree the article does make a good case for responsible use. With all the other options out there though - is there even a need to screw around with methyls?

    BV
  13. I know nothing...
    DmitryWI's Avatar
    Join Date
    Feb 2004
    Age
    35
    Posts
    2,532
    Rep Power
    1412
    Level
    38
    Lv. Percent
    31.59%
    Achievements Activity ProPosting Pro

    mightyconan is trying to make feel himself better, but I sure am glad never tried m1t either.
  14. Senior Member
    natedogg's Avatar
    Stats
    6'0"  220 lbs.
    Join Date
    Dec 2004
    Age
    32
    Posts
    2,414
    Rep Power
    1337
    Level
    39
    Lv. Percent
    9.89%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by kwyckemynd00
    LOL?! For me, I got "less" parandoid when I read this.

    This article reaffirmed my current stance on the issue of AAS. Basically, K.I.S.S. + responsible use and NOT using harsh orals for years straight without a break + avoiding any unecessary supplementation (i.e. Nolva every damn day) and a few other things make AAS pretty damn safe.
    Yep. Pretty simple if you ask me.
  15. Senior Member
    Lean One's Avatar
    Join Date
    Nov 2003
    Age
    42
    Posts
    2,673
    Rep Power
    1471
    Level
    38
    Lv. Percent
    27.62%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by mightyconan
    GLAD U NEVER TRIED M1T, ARE U KIDDING ME OR WHAT. THAT ARTICLE JUST SAYS THAT NON STOP USE FOR YEARS, CAN DO LIVER DAMAGE, THE ARTICLE NEVER EVEN GOES INTO THE MANY HERBS AND SUPPLEMENTS ONE CAN TAKE TO CLEANZ THE LIVER. AND THIS OCCURS WITH BODYBUILDERS WHO TAKE HUGE STACKS OF ROIDS, NOT MERELY 30 MG OF M1T, GIVE ME A BREAK. DOING M1T OR SUPERDROL FOR A MONTH WON'T DO ANYTHING.
    Dude, adjust your atitude, kill the caps lock, and learn how to spell.

    You're off to a rocky start here...
  16. New Member
    mightyconan's Avatar
    Join Date
    Apr 2005
    Age
    48
    Posts
    47
    Rep Power
    142
    Level
    10
    Lv. Percent
    0.53%

    hmmmm, can't spell huh, mr. "underware" man, thats actually spelled "underwear"
  17. Board Moderator
    Unbreakable
    David Dunn's Avatar
    Join Date
    Mar 2003
    Age
    49
    Posts
    11,772
    Rep Power
    1056388
  18. The True Warrior is one who conquers oneself
    hamper19's Avatar
    Stats
    5'7"  191 lbs.
    Join Date
    Oct 2002
    Age
    35
    Posts
    1,471
    Rep Power
    883
    Level
    32
    Lv. Percent
    30.92%
    Achievements Activity ProPosting Pro

    Quote Originally Posted by laz
    Another thread that states how bad nolva can be on the liver! What is a good alternative to nolva that is less stressful on the liver???
    Rebound XT worked really well for me this past pct. I had nolva on hand, but I used RXT and LXT for pct, worked REALLY well, got stronger, and kept off the fat.

    h19
  19. Registered User
    BigP0ppa3's Avatar
    Join Date
    Jan 2005
    Age
    39
    Posts
    269
    Rep Power
    255
    Level
    15
    Lv. Percent
    54.32%

    Quote Originally Posted by B5150
    Another good read - thanks B!
  20. Board Moderator
    Unbreakable
    David Dunn's Avatar
    Join Date
    Mar 2003
    Age
    49
    Posts
    11,772
    Rep Power
    1056388

    Quote Originally Posted by laz
    Another thread that states how bad nolva can be on the liver! What is a good alternative to nolva that is less stressful on the liver???
    Nolvadex, an estrogen blocker that few bodybuilders know can also cause peliosis if used in too high a dose for too long.

    I don't mean to be rude, but...where in this statement can you determine how bad nolva can be on the liver?
  21. New Member
    sentientcj's Avatar
    Join Date
    Jun 2005
    Age
    34
    Posts
    1
    Rep Power
    116
    Level
    1
    Lv. Percent
    10%

    good read, thnx
  22. Elite Member
    BigVrunga's Avatar
    Join Date
    Nov 2002
    Age
    38
    Posts
    5,063
    Rep Power
    2684
    Level
    49
    Lv. Percent
    26.85%
    Achievements Activity ProPosting ProPosting Authority

    Hepatoxicity: Fact or Fiction by Roy Harper
    I wonder how jacked those rats got during that study?

    I agree the the degree of hepatoxicity caused my oral steroids is generally over-hyped. But still, its best to err on the side of caution. You only have one liver, and everyone is different. What defines 'long term' would be specific to the individual.

    For instance, if someone was genetically predisposed to liver and/or other health problems, a few 4 week cycles might be enough to cause lasting damage. In others, a lifetime of oral steroid use might result in nothing but pounds of lean mass.

    The only safe way to go about is to get a blood panel to see how the drugs effect you specifically...I still remember Supersoldier's "This is your liver on M1T'" log, when he started Nolva for PCT is liver values were way out of the safe range. The came back to normal within a few weeks, but still...

    ...Is it worth putting yourself through those kinds of risks for a few pounds of muscle and an extra 25lbs on your bench press? That's your own decision.

    I know that most of us (myself included) choose to use anabolics when we're not even close to our natural genetic max. It literally takes years to really find out what's good for your body, the best way to eat and train for your genetics to maximize gains, etc.
    So in someways, I think that using steroids before you've reached these goals is a bad thing, because you may never get up the motivation to really dedicate yourself unless you're on a cycle. You guys know what I mean, you slack off a bit here and there - but when you're on a cycle THAT's what its game time, when training and diet take top priority.
    So you have to take that into account when you decide to accept the risks of anabolic drugs. I do think that they can be perfectly safe - but you're taking risks no matter how you look at it, especially with new drugs that don't have any long term tests in humans.

    I'm preaching to the choir here, so Ill give it a rest But still, it's something to consider.
  23. Board Moderator
    Unbreakable
    David Dunn's Avatar
    Join Date
    Mar 2003
    Age
    49
    Posts
    11,772
    Rep Power
    1056388

    Quote Originally Posted by BigVrunga
    I do think that they can be perfectly safe - but you're taking risks no matter how you look at it, especially with new drugs that don't have any long term tests in humans.

    I'm preaching to the choir here, so Ill give it a rest But still, it's something to consider.
    I agree with you completely.
  24. Registered User
    Neuromancer's Avatar
    Join Date
    Feb 2004
    Age
    35
    Posts
    954
    Rep Power
    615
    Level
    24
    Lv. Percent
    79.49%

    Quote Originally Posted by BigVrunga
    I wonder how jacked those rats got during that study?

    I agree the the degree of hepatoxicity caused my oral steroids is generally over-hyped. But still, its best to err on the side of caution. You only have one liver, and everyone is different. What defines 'long term' would be specific to the individual.

    For instance, if someone was genetically predisposed to liver and/or other health problems, a few 4 week cycles might be enough to cause lasting damage. In others, a lifetime of oral steroid use might result in nothing but pounds of lean mass.

    The only safe way to go about is to get a blood panel to see how the drugs effect you specifically...I still remember Supersoldier's "This is your liver on M1T'" log, when he started Nolva for PCT is liver values were way out of the safe range. The came back to normal within a few weeks, but still...

    ...Is it worth putting yourself through those kinds of risks for a few pounds of muscle and an extra 25lbs on your bench press? That's your own decision.

    I know that most of us (myself included) choose to use anabolics when we're not even close to our natural genetic max. It literally takes years to really find out what's good for your body, the best way to eat and train for your genetics to maximize gains, etc.
    So in someways, I think that using steroids before you've reached these goals is a bad thing, because you may never get up the motivation to really dedicate yourself unless you're on a cycle. You guys know what I mean, you slack off a bit here and there - but when you're on a cycle THAT's what its game time, when training and diet take top priority.
    So you have to take that into account when you decide to accept the risks of anabolic drugs. I do think that they can be perfectly safe - but you're taking risks no matter how you look at it, especially with new drugs that don't have any long term tests in humans.

    I'm preaching to the choir here, so Ill give it a rest But still, it's something to consider.
    Bravo...Bravo...

  25. New Member
    BoxingFool01's Avatar
    Join Date
    Apr 2005
    Age
    34
    Posts
    47
    Rep Power
    141
    Level
    6
    Lv. Percent
    94.23%

  26. New Member
    credible_threat's Avatar
    Join Date
    Dec 2003
    Posts
    54
    Rep Power
    161
    Level
    7
    Lv. Percent
    20.63%

    I've often wondered about the possibility of users of 17aa steroids that unknowingly have hep-b or c.
  

  
 

Similar Forum Threads

  1. SERM use good or bad??? GREAT READ! NOLVA USERS MUST SEE!
    By SWOLL in forum Post Cycle Therapy
    Replies: 14
    Last Post: 10-19-2012, 02:09 AM
  2. great read on different way of using slin
    By citystreets in forum Anabolics
    Replies: 7
    Last Post: 12-28-2009, 10:24 AM
  3. melatonin--Interesting article--Great READ!
    By Guest in forum Supplements
    Replies: 7
    Last Post: 06-20-2006, 04:03 PM
  4. Anyone interested in Sci/Tech articles, this is a GREAT read!!
    By LakeMountD in forum News and Articles
    Replies: 2
    Last Post: 01-13-2006, 10:02 PM
  5. Great Read! (A MUST for Newbies!)
    By Crankin'steiN in forum Anabolics
    Replies: 5
    Last Post: 05-18-2003, 11:14 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in