Steroid doping tests ignore vital ethnic differences in hormone activity

  1. Steroid doping tests ignore vital ethnic differences in hormone activity

    Current steroid (testosterone) doping tests should be scrapped for international sport, because they ignore vital ethnic differences in hormone activity, suggests research published ahead of print in the British Journal of Sports Medicine.

    Testosterone, and other hormones that boost testosterone levels, such as growth hormone, are among the most widely abused performance enhancers used in sport, according to the World Anti-Doping Agency.

    Evidence of abuse is determined by the testosterone: epitestosterone ratio, or T:E ratio for short, in the urine. The threshold is set at above four for everyone, and confirmed by chemical analysis (gas chromatography).

    To highlight the inadequacy of the current test, the researchers tested the steroid profiles of football players of different ethnicities, after they had deliberately added steroid to their urine samples.

    They used gas chromatography, and took account of a variation (polymorphism) in the UGT2B17 gene.

    Previous research has indicated that variations in this gene account for some of the differences in the urinary T:E ratio between men of white and Asian ethnic backgrounds. The gene affects metabolism, and therefore the rate at which testosterone is passed out of the body into the urine.

    They included 57 men of Black African origin; 32 of Asian origin; 32 of Hispanic origin; and 50 of white (Caucasian) origin in their research. All the men were aged between 18 and 36.

    The results revealed the genetic variation in almost one in four (22%) of the African footballers; in eight out 10 (81%) of the Asian players; one in 10 of the white men, and in 7% of the Hispanic players.

    Based on these findings, the Swiss researchers "recalibrated" the thresholds for each ethnic group.

    The new T:E ratios were: 5.6 for men of African origin; 5.7 for white men, and 5.8 for men of Hispanic origin. For men of Asian origin, the ratio was 3.8.

    A single indiscriminate threshold to pick up steroid abuse in international sport is "not fit for purpose," the authors conclude. Instead, the reference ranges should be tailored to an athlete's individual endocrinological (hormonal) passport, they suggest.

    "[Such a] passport may detect modifications induced by abuse of testosterone and its precursors, but also alterations in the steroid profile caused by indirect androgen doping products," they conclude.

  2. hmmm. Good read. Interesting though, plus I was surprised by the results of the allowances a bit.

    How much money would it cost though to use the code in a persons genes to set up a profile for the T:E ratio. I mean, normal roid testing isnt that bad. But something where every person has personal data modified to their genetic blueprints, that sounds kinda expensive. I say let the football players take roids, makes em play harder, game is better, and we see people fly higher

  3. lutherblsstt
    lutherblsstt's Avatar

    All testing should be stopped. Just let them do what they do.

    Here is a piece of unbiased information on the educated use of anabolic steroids. Not surprisingly, this piece of footage never received much attention from the main stream media.

    YouTube - Truth about Steroids
    Last edited by lutherblsstt; 03-16-2009 at 10:29 PM. Reason: add

  4. the T:E ratio testing is silly, as it is possible to be outside that naturally. testing for metabolites of dianabol, etc is ok though

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