Millennium Sport Technologies
CEE HCL 3000 write-up




Everyone who has experienced the “bloat” from creatine knows that creatine monohydrate is poorly absorbed by the body and rapidly converts to byproduct. Creatine’s effectiveness is dependant upon the cells ability to absorb it. The poor absorption rate of regular creatine monohydrate requires the creatine user to ingest large dosages of creatine to achieve desired effect. This in turn can create unwanted side effects such as stomach bloating, water retention, and diarrhea.

One theory is that creatine works by drawing water into the muscle cell. Since most supplemental creatine monohydrate is not absorbed, the unabsorbed creatine can hang outside the target cell with the water it was initially trying to draw in. The end result is the notorious "creatine bloat."


All living cells have a lipid bilayer. This is a membrane composed only of lipid (fat) molecules. This lipid bilayer is the foundation of all biological membranes, and is a prerequisite of cell-based life. Passive permeation is a process that describes the diffusion of a substance across a cell membrane through the use of lipids as transport mechanisms. Esters are organic compounds that are formed by esterification - the reaction of alcohols and carboxylic acid. The most common esters found in nature are in the fat tissue in animals. Sound familiar?

Creatine monohydrate is semi-lipophilic. This means that it inefficiently uses fat as a transport mechanism. The esterification of substances will increase their lipophilic abilities. Therefore, esterified creatine will use fat more efficiently to permeate the cell wall and exert its effects upon cellular function vs. unesterified creatine. This means absorption of esterified creatine is significantly increased, up to 30 times more than creatine monohydrate. Side effects such as the bloating, cramping, diarrhea and water retention are kept to an absolute minimum.

As a dietary supplement, take one 4 capsule serving with 16 ounces of water 30 minutes prior to working out. Continue consuming water throughout your workout. Take another 4 capsule serving immediately following your workout.

Serving Size: 4 Capsules
Servings Per Bottle: 60
Each 4 Capsule Serving Contains:
Creatine Ethyl Ester HCL… 3000mg (3 grams)

Do not take if you are pregnant, nursing or suffer from kidney disease. Consult your physician prior to use. KEEP OUT OF REACH OF CHILDREN!

*These statements have not been evaluated by the FDA and are not meant to diagnose, treat or cure any disease.


References:
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Kreider, R.B., 1999. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Medicine 27:97-110.

Becque, M.D., et al. 2000. Effects of oral creatine supplementation on muscular strength and body composition. Medicine and Science in Sports and Exercise 32: 654-658.

Ingwal JS, Weiner CD, Morales MF, Davis E, Stockdale FE: Specificity of creatine in the control of muscle protein synthesis. J Cell Biol 63:145-151, 1974.

Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003 Nov;17(4):822-31.

Kambis KW, Pizzedaz SK. Short-term creatine supplementation improves maximum quadriceps contraction in women. Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):87-96.

Gill ND, Hall RD, Blazevich AJ. Creatine serum is not as effective as creatine powder for improving cycle sprint performance in competitive male team-sport athletes. J Strength Cond Res. 2004 May;18(2):272-5.

Rawson, E.S., et al. 1999. Effects of 30 days of creatine ingestion in older men. European Journal of Applied Physiology 80: 139-144.

Sosin D.M., Sniezek J.E., Thurman D.J.. Incidence of mild and moderate brain injury in the United States, 1991. Brain Inj 1996 Jan;10(1):47-54.