Test Compound Cream Time to Steady-State

  1. Test Compound Cream Time to Steady-State


    What is the steady-state time, from starting a compounding T cream for the average person, to reach constant T levels with the delivery system?


  2. Quote Originally Posted by 4aminsomniac View Post
    What is the steady-state time, from starting a compounding T cream for the average person, to reach constant T levels with the delivery system?
    ============================== =======
    Interesting factoid (basically women only, not sure if apply to men)
    Progesterone
    oral --> half life 6-8 hrs
    transdermal cream --> 6-8 weeks for serum to equilibrate, even with symptomatic improvement (do urine testing when on creme)
    transdermal gels ---> 3-4 hrs (gels are neat)
    ------
    same with testosterone, gells are preferable, act faster, creams stabilize in 6-8 week, hard to figure dosing.
    ===========================
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  3. Quote Originally Posted by JanSz View Post
    ============================== =======
    Interesting factoid (basically women only, not sure if apply to men)
    Progesterone
    oral --> half life 6-8 hrs
    transdermal cream --> 6-8 weeks for serum to equilibrate, even with symptomatic improvement (do urine testing when on creme)
    transdermal gels ---> 3-4 hrs (gels are neat)
    ------
    same with testosterone, gells are preferable, act faster, creams stabilize in 6-8 week, hard to figure dosing.
    ===========================
    Yes, interesting. My compounding pharmacist created a PLO gel for me claiming extremely high absorption rate due to the materials used for a compared to a standard gel.

    Yet, he said it would take 6-8 weeks to reach a steady-state and re-testing should wait until then.

    On the other hand, I have also heard from a Dr. that it only take 2-3 days for a Test gel to reach its steady-state and your T levels should be about the same at this point as 6-8 weeks later..not withstanding other things like shutdown of your own system etc..all things remaining the same.

    So with this PLO gel formula, the pharmacist said there is no % level, like a 5-10% cream. Due to the method of materials they use and up to about 50mg doses per 1ml, you could have nearly 100% absorption. But, it all depends on the person. But he said it definitely was way beyond a 10% cream and much better than a gel. Basically cream>gel>plo gel was the worst-to-best.

    Would like more info/studies showing this info if anybody has links. Thanks

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