Lab GURUS: what tests for anxiety
- 03-18-2008, 11:07 PM
- 03-18-2008, 11:17 PM
Why don't you make an appointment to see your Doctor instead of trying to self-diagnose and treat yourself via an internet message board.
03-19-2008, 12:04 AM
03-19-2008, 02:32 AM
I don't know if you've tried Busbar or any of the SSRIs (e.g. Paxil). Many have good fortune with them. Others have good luck with anti-seizure meds (e.g. neurontin) and atypical anti-psychotics (e.g. serzone, lamictal).
There are neurotransmitter tests, though I am not aware of any that are believed to be reliable, at least by any consensus. I've read that for it to be reliable, it would need to come from the brain, rather than blood, urine or saliva.
I'm sure Jan can recommend some labs.
03-19-2008, 10:12 AM
03-19-2008, 11:31 AM
12/07 Saliva Cortisol 12pm: 5 ng/ml [5-10] LOW-NORMAL
12/07 Saliva Cortisol 4pm: 3 ng/ml [3-8] LOW-NORMAL
12/07 Saliva Cortisol 12am: 8 ng/ml [1-4] HIGH
2/07 Saliva Cortisol AM: 5.2 ng/ml [3.7-9.5]
2/07 Saliva Cortisol PM: 0.3 ng/ml [0.4-1.0] LOW
Urine Epinephrine 6.3 ug/gCr [day:8-12, night:1-3]
Urine Norepinephrine 31.4 ug/gCr [day:35-50, night:20-30]
Urine Dopamine 124.9 ug/gCr [day:110-175, night:80-120]
Urine Serotonin 75.1 ug/gCr [day:150-200, night:100-175] LOW
Urine GABA 1.6 umol/gCr [day:1.5-4.0, night:1-3] LOW
Urine Glutamine 400.8 umol/gCr [day:150-400, night:100-350]
Urine Glutamate 26.9 umol/gCr [day:10-35, night:8-20]
Urine PEA 236.6 nmol/gCr [day:175-450, night:125-300]
Urine Histamine 19.6 ug/gCr [day:10-20, night:5-15] HIGH-NORMAL
Serum DHEA-S 361 ug/dL [35-430] WAS LOW BEFORE SUPP
Serum TSH 1.740 uIU/mL [0.3-5.6]
Serum Free T3 3.4 pg/mL [2.0-4.2]
Serum Free T4 1.12 ng/dL [0.87-1.56]
Serum Reverse T3 351 pg/mL [90-350]
Serum Thyroglobulin AB <80 IU/mL [normal]
Serum Thyroid Peroxidase AB <20 IU/mL [normal]
Serum ACTH test [normal]
Serum Testosterone-Free 18.59 ng/dL [5-21] WAS LOW BEFORE CLOMID
Estradiol 28.5 pg/mL [0-56]
Thanks guys. As you can see, I have done much of this. I really do not want an SSRI, IMO its only masking the problem, and adds a bunch of new sides. I want to know the reason why I feel the way I do. My doctors are out of ideas for tests. My endo is useless, checked TSH, ACTH, said they're normal and I should just take xanax. My ND tells me to take tryptophan/5-HTP for low serotonin which I agree, helps some w/ sleep but not anxiety yet. Cortisol runs low, I don't see how that could cause anxiety, unless it's spiking up.
I will look into the metabolic analysis. What about some kind of amino/vitamin/mineral deficiency (NutrEval)? What about aldosterone causing some kind of elecrolyte imbalance? What about homocysteine to check methylation issues? Anything else, I am trying to cover all bases.
03-19-2008, 12:52 PM
Metabolic Analysis Profile
You will get a list of supplements to take,
name, daily dose, additional advice.
No need to involve your doctor in making basic guesses.
Unless your doc is top notch researcher,
results of the test will give you better advice that given by your doctor.
03-19-2008, 02:03 PM
03-19-2008, 02:12 PM
While I understand your feeling that SSRIs are bandaids, it may be your only resort. While it's possible that hormonal rebalancing will quell some of your anxiety, I would remain open minded. I think you may be well served by trying hCG rather than clomid, which may serve to increase dopamine. I haven't heard many good things about clomid monotherapy. That said, your free-T is pretty good.
I don't have that much confidence in L-tryp and 5HTP. They may help you sleep, but they are usually not that affective for managing day-time anxiety.
Good luck and hang in there.
03-19-2008, 02:32 PM
All that being said, I do occasionally take 25mg trazodone when I really need some help sleeping... works great with no sides except stuffy nose... it is not an SSRI... libido actually increases on it.
As far as clomid, it has brought my total T from 260 to 600, and free T from 6 to 18 in 2 weeks. I am not opposed to HCG in the future, but why take something suppressive before at least trying a SERM like clomid which may jump-start the HPTA.
03-19-2008, 06:15 PM
I posted its report here:
JanSz-Metabolic Analysis and Cellular Energy
I do not remember its (nominal) cost.
Cost to me was $0.00 after insurance.
Latter I did ONE.
ONE consist of:
GDX ONE - Optimal Nutrition Evaluation
The ONE - Optimal Nutrition Evaluation - (Cost $472.01) bill dec/10/2007 consists of:
Amino Acid Analysis
Oxidative Stress Analysis
Out of pocked was minimal.
I posted ONE resport on the above link.
Look at thos reports, specially look for the advice on corrective action,
first discussion, then detailed list of supplements, daily dose and additional testing if any.
All in all I paid about $50 for all the Genova tests I did to date.
One of the reasons for insurance payments is Genova's instructions to doctors on how to fill up proper justifications for the test. I wish Quest made such an effort. I am sure 50% of insurance non-coverage is just wrong paperwork. Another words, complicated bureocracy, not real reluctance to pay.
03-19-2008, 06:25 PM
03-19-2008, 06:35 PM
In the meantime, try a little lemon balm and/or oat seed extract with your tryptophan doses. These have a nice, mild anti-anxiety effect with no other negative side effects (at least for me and most people). Lemon balm also re-establishes and enhances your sleep cycle.
Other super-simple things to add in just to ensure your body is getting what it needs to produce enough serotonin..folic acid upwards of 1-3 mgs per day, chromium 50 mg, and selenium. These all act as co-factors in nuerotranmitter function and production and from my experience, they can help a lot if you are low on them. All fairly cheap to boot.
03-19-2008, 06:36 PM
NutrEval (old Style)
There is also
NutrEval(new) ( my second choice).
Listen to podcast here (about ONE)
GDX Nutritional Laboratory Assessments
If you get ONE (like I did), right away you will find out that you are definitely want to add Essential & Metabolic Fatty Acid and Elemental analysis.
That was my way.
You be better of doing the NutrEval right away and be done with it.
GDX NutrEval Profile
03-19-2008, 09:29 PM
03-20-2008, 11:14 AM
Plenty of anxiety IS of psychological/emotional origin. I used to have episodes of anxiety that would last for weeks, where I worried constantly, had difficulty eating and sleeping and felt like I was ready to jump out of my skin. I managed to keep myself distracted from it by being manically active and overworking, but eventually, coping in that way was beginning to really wear me out.
I went into psychotherapy and began to feel better in a matter of weeks - no pills, no lab tests, just talk therapy. The psychtherapy extended for nearly two years, but, having gone through it, I never have anxiety of that kind any more.
I understand that not everybody has the time, patience and coin for psychotherapy (I paid for it out of pocket), but keep it in mind as an option.
03-20-2008, 11:33 AM
03-20-2008, 02:12 PM
03-21-2008, 01:08 AM
Good luck -- and get going with the talk therapy.
03-21-2008, 05:26 PM
Cool news, my doc agreed to order the Genova Metabolic test. Not sure about the pocketbook damage yet. JanSz, I'll post results when I get 'em.
03-22-2008, 04:31 PM
You've done most of the tests, what are you taking? You def. need cortisol and possibly florinef as well. That and get the thyroid up and cranking. those two are huge as well as test.
until those 3 are straigthened out for at least 3 months, id hold off on anything else unless you just need a bandaid to get by.
03-24-2008, 03:41 PM
03-24-2008, 10:22 PM
03-25-2008, 10:23 AM
03-25-2008, 01:04 PM
03-25-2008, 01:37 PM
03-25-2008, 01:46 PM
And NO, I'll never take an SSRI again...
03-25-2008, 04:05 PM
03-25-2008, 09:18 PM
03-28-2008, 11:53 AM
UPDATE: Just found out that I have a gluten sensitivity, and it can cause neurological symptoms and low serotonin... going gluten-free for awhile to see how I feel.
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