Why do our testes atrophy on TRT?

  1. Why do our testes atrophy on TRT?

    If your T levels were at level X when you were 25, and are now at X minus 30%, at age 50 say, why would replacing T back to X levels cause testicular atrophy? At one time it was a normal level and now the body sees it as too much?

    Has anyone heard of ramping up T very slowly, just titrating it a bit week to week and at the same time removing excess E, so that total circulating hormone was the same, why would you get shut down?

  2. They atrophy from lack of use (more)

    Just as with muscles, it's "use it or lose it". External T shuts down the body's natural feedback loop. When your brain senses the extra T in your system it figures the testes don't need stimulation and shuts off the LH/FSH hormones that make them work. Now idled, the testes lose the ability to work after too long a time. Imagine what your muscles would look and work life if you hardly ever moved or exerted them. Sorta the same idea.

  3. Anyman is 100% right.

    That said, if you include hCG as part of your TRT, your testes should not atrophy.

    hCG acts as a LH mimic, thus stimulating your testes and maintaining your endogenous baseline testicular output.

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