I just switched pharmacys and the new prescription is made with versabase. The old rx was carbomer. The versabase is thicker like a cream while the carbomer was thinner.
I don't feel as well on the versabase. I've tried it for a couple of weeks. I'm looking for someone else's experience. Does the versabase result in higher or lower levels vs the carbomer?
really? hmm, Dr. John switched us from College back to University pharm and they use more of a cream....the cream seems to make sure their is no 'frosting' but hmm....ill talk to him about it fri as ive had some other issues.
Exact same situation here. Let me know what you find out.
Any compounding pharmacists on the board? Maybe they can explain the different absorption characteristics of the two. I cannot find a reference. Maybe a dose adjustment is in order.
The Versabase is a proprietary cream base made by PCCA available only to PCCA members (Professional Compounding Centers of America). It is proven to delivery hormones through the skin, and should provide more penetration enhancement than carbomer gel. That being said, carbomer is exactly what Androgel is made of, so we know that it can work also. Any time you switch bases there will be a difference in absorbtion. As to the amount of difference, well, I don't think anyone can be certain about that. You will probably need to test levels. I would expect levels to be higher with Versabase if using the same dose, but as we all know individuals vary.
IIRC you are pharmacist at compounding pharmacy?
From your post I understand:
Is it possible to make pregnenolone gel?
Reason for this question:
Looks like gel may be better than cream
I was listining to (I think):
GS02m - Estrogen Metabolism: Modifying Risk in Clinical Practice
Conference: A4M Orlando 2006
Speaker: Patrick Hanaway MD
Length: 31m 07s - 66 Slides
April 9, 2006 5:00 pm - 5:40 pm
and good doctor is taking about problems when women on HRT would use progesterone cream or pills.
they would produce large amount of secondary estrogens that they are not able to clear.
That does not happen when they use gel.
Playng safe, I think that it also may be my problem, I am using pregnenolone cream.
I will know better when my Estroessence test come back.
JanSz, yes I am a compounding pharmacist. There is no reason you couldn't make pregnenolone in a gel. Most of the "conventional wisdom" says a cream will give you better penetration through the skin, but clearly gels also work. I have done almost exclusively creams in my topicals though (mostly for women's HRT). Dr. Hanaway is great, but I'm not sure what that would be in reference to.
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my next will be pregnenolone gel, but first I will double check results of my Estroessence test.
E2 or some of it is eventually converted to
When women use progesterone cream, they get too much of this stuff, body is not able to get rid of it.
Supposedly it is easier with gells.
This is one year old knowledge (I think).
I have some of my notes I have made while listening:
Metabolism of Estrogen
+ Major path (450)
+ Hydroxylation (C2, C4, C16)
Genomic diferences are reson for different speed reaction, %% of reactions and speed of
elimination of different metabolites.
Different genes = different outcome
CYP450 1A1 --> 2OH
CYP450 1B1 --> 4-OH ---> (Quinones Phase II) (cancer)
CYP450 3A4/5 --> 16OH (cancer)
Dr. Hanaway is at Genova diagnostics.
Do not recall his position, but close to the top.
His presentation contains mostly substance, very little time to snooze during his presentation.
Is there any published data on testosterone absorption in Versabase? I found some estrogen absorption claims. Could the Versabase be more sustained release vs the other?
dsade, Alcohol is a penetration enhancer (over just water or the powder) but generally it is thought that fatty acids present in creams allow for interaction with the phospholipids in the skin and allow for more penetration due to being lipid soluble. The gold standard for now is PLO gel with lecithin and isopropyl palmitate or myristate providing the lipid component. However, there is some thought that lipid soluble drugs (like hormones) tend to partition out of their base more quickly when the base is more hydrophilic (like alcohol). More quickly is not necessarily better with hormone delivery though. That is rambling a bit but it's just off the cuff.
nuker- there is published info on versabase with progesterone and promethazine penetration through cadaver skin, but I don't have it with me.
fwiw - I know the difference between testosterone and estrogen is one carbon atom. I'd speculate that if some particular base makes for better absorption of one it would make for better absorption of the other.
The issue was not (directly) about better absorption, or speed of delivery.
He studies via EstroEssence and EstroGenomic testing,
amount of each hydroxy and metoxy estrones and quinones and estriol.
That is Phase I and Phase II metabolism of estrogen.
It makes difference if desired reaction happens faster or slower.
While delivering external progesterone he liked gel best, when choice was pills, cream or gel.
Again, that was about women and progesterone.
16a-OHE and Quinones are carcinogenic, we want to have less of them.
To have less can be achieved by
Thats why I try to find a pharmacy that I'm happy with and just stay with them so that I won't have to go through all that trouble again. Unless, they use a commercially available base which you are happy with and which you can instruct your new pharmacy to use. I prefer a vanishing cream base because it delivers slow and steady. At women's international pharmacy, they use their own proprietary vanishing cream base. Other commercially available vanishing cream bases are Vanicream and Dermabase, that are widely used. The "Cosmetic HRT" vanishing cream base available from PCCA is also supposed to be very good. Even when switching between vanishing cream bases, I would redo labs.
With Androgel my TT~1000
Then I switched to 1gram of 10% Tcream, that is I applied same amount of testosterone as before.
I dropped Tcream and switched to shots.
I still worry about cream because I am using
pregnenolone cream from same pharmacy.
Both Tcream and preg cream looks identical, I bet the base is same.
I plan on switching to gel.
I hope that they have a gel.
Is any body using their gel, what are the results?
With 1gram of 100mg/1gram preg cream my pregnenolone tested in very low normal.
Pregnenolone=11 (10-200) ng/dL
I increased and now am using 2grams/day.
Philip Miller M.D. author of "Life Extension Revolution" is not concerned with progesterone at 2.5 times top of the range. I prefer to keep progesterone and any other hormone for that matter within the normal range.