- 12-02-2007, 08:33 AM
- 12-02-2007, 10:40 AM
12-05-2007, 11:57 AM
12-05-2007, 12:39 PM
I just heard, I think it was here:
PROLibraries.com - Online Professional Education
GS02m - Estrogen Metabolism: Modifying Risk in Clinical Practice
Conference: A4M Orlando 2006
Speaker: Patrick Hanaway, MD
April 9, 2006 5:00 pm - 5:40 pm
that women on TRT that use either oral (pills) or cream Progesterone,
have a problem with clearing estrogen metabolites.
They produce lots of them.
So the solution is to use progesterone in gel.
I know, you are talking pregnenolone, but it may also apply.
I will dig some more, plus in few days I should have my Estroessence results.
There is when one see mess if not properly treated.
If I see something out of line there or even with out, next time I am ordering my pregnenolone as a gel.
Right now I just started new jar, 2 months supply.
Wonder if there are different gells?
I suggest buyng this $20 lecture, I am sure I am missing at least half of very good information.
Possibly we could have more inteligent discussion if couple of guys would read this.
12-05-2007, 01:04 PM
12-05-2007, 04:34 PM
I am taking about way of getting the pregnenolone into our bodies.
I am not questioning if we need it or not (not yet, due to lack of knowledge).
Apparently (with women using progesterone) form of delivery makes big difference in their estrogene clearing.
looks like only gel is ok.
I am just making wild guess, that possibly it is similar situation with pregnenolone.
Remember when I was using Androgel I was responding beatifully (average by the book).
When I changed to Tcream I went down hill.
Estrogene clearing means, that they produce tonns of first and second Phase
and do not have enough (chemicals, vitamins what not)
to process it and get rid of it.
Some of this are in not big enoug quantity or quality:
Metabolism of Estrogen
+ Major path (450)
+ Hydroxylation (C2, C4, C16)
Genomic diferences are reson for different speed reaction, %% of reactions and speed of
elimination of different metabolites.
Different genes = different outcome
CYP450 1A1 --> 2OH
CYP450 1B1 --> 4-OH ---> (Quinones Phase II) (cancer)
CYP450 3A4/5 --> 16OH (cancer)
12-05-2007, 06:57 PM
If a person is low in cholesterol (under 160) I would recomended pregenolone. Taking 50 mgs topical pregenlone a day i beleived help to keep my e2 in check with out armidex as well other varaibles where consitant. I stopped the preg and my e2 went sky high. With my cholestrtol at 120 I NEED IT FOR SURE other people may not..
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