The benefits of progesterone are not limited to women. Excess estrogen can be associated with benign hyperplasia and prostate cancer. Progesterone administration inhibits the aromatase enzyme responsible for the conversion of testosterone to estrogenic compounds that produce prostate cell mutation. Progesterone reduces the production 4-hydroxyestrone, a mutagenic form of estrogen, while enhancing the production of cancer-preventing estriol. Consequently, progesterone replacement for men, implemented at lower doses than for women, can potentially prevent prostate cancer and, in principle, boost free testosterone levels. Furthermore, progesterone use can help boost bone density in men, a useful event for aging men, as well as help protect brain cells against so-called hyper-excitotoxicity.
So, in principle, the use of progesterone cream is not limited to women. Such use by men should, in my opinion, be supervised by a knowledgeable medical practitioner to obtain maximum benefits.