Spruce Lignans To Help Control Estrogens?

  1. Spruce Lignans To Help Control Estrogens?

    I was wondering what you smarter gents thought about spruce lignans, an eterolactone precursor.

    A natural hair guru, immortalhair, believes enterolactone food stuffs are a strong defense from 17beta-hydroxsteroid the catalyst for androstenedione (which he also believes has strong ties to hair loss). Enterolactone also apparently inhibits aromatase.

    Jansz, doesn't the LEF Breast Health Formula also include spruce lignans? Perhaps this is a trend that's just getting started.

    Mammalian lignans and genistein decrease the activ...[J Steroid Biochem Mol Biol. 2005] - PubMed Result

    Dietary sesamin is converted to enterolactone in h...[J Nutr. 2005] - PubMed Result

  2. Believes Androstenedione ITSELF causes hairloss, and not the downstream androgenic products?
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  3. Quote Originally Posted by dsade View Post
    Believes Androstenedione ITSELF causes hairloss, and not the downstream androgenic products?
    Here is a quote from his site:

    Isoenzymes such as 17beta-hydroxysteriod dehydrogenase (17beta-HSD) and 5-alpha-reductase are key mediators in the pathogenesis of AGA. Thus (17beta-HSD) has been largely ignored.

    The 17beta-HSD type 1 enzyme (17beta-HSD1) converts estrone to estradiol, which is adversely expressed in estrogenic based cancers (i.e., prostate and breast). Moreover, 17beta-hydroxysteriod dehydrogenase is responsible for increases in androstenedione from testosterone.

    Simply put, androstenedione equals hair loss. Pro-hormones in general equate to increased hair loss. Reducing endogenous androstenedione conversion from testosterone by way of inhibiting 17beta-hydroxysteriod dehydrogenase is a significant piece to the hair loss puzzle.

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