JanSz-Metabolic Analysis and Cellular Energy

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    JanSz-Metabolic Analysis and Cellular Energy


    JanSz-Metabolic Analysis and Cellular Energy

    --------------------------------------------------------------------------------

    ============================== ===========================
    Calling all shrinks and all knowledgeable others for a helpful opinion and advice.
    ============================== ===========================


    Attached pictures are copies of the report.
    Page # 8 of report contains interpretation at glance, suggested remedies and confirming tests.

    Page # 9 is my own summary and supplements that I will possibly buy from LEF based on advice contained on page # 8.

    The reports highlights following:
    -----------------
    Neuro transmitters
    low Vanilmandelic acid (VMA)
    see:
    mental depression
    mood swings or bipolar disorders
    specially caught my eye suggestion of copper deficiency.
    My previous blood test indicated too much copper,
    I switched to copper-less multivitamins and
    my latest blood test indicated copper to be within range.
    Now this report (urine) suggest copper deficiency, hmmm.
    ------------------
    Cellular and Mitochondrial function
    Lactic Acid low
    no known problems with it
    -----------------
    Cofactors -dependent
    Forminiglutamic Acid (FIGIu) elevated
    Pyroglutamic Acid low

    follows all kind of reasons and possible reasons
    -----------------
    ============================== ============================== =============
    Value of each analyzed item is shown on a chart that shows position of that item relative to its range.
    Only those that are not within range are highlighted in further report.
    But the way we look at ranges, we usually want to be ether in the middle of range or at the top,
    depending on our understanding of how given item affect our health.

    So with that approach many more items would need attention.
    ============================== ============================== ==============
    I am 67yo, 5'9" 160#, cancer in left thigh LipoSarcoma
    My actual complaints.
    Could use some more energy so I could exercise more and sweat less.
    I start sweating very quickly, long before I am actually tired.
    My pines works ok, but it is old and slow to respond.
    Often with hard pines it is hard to get it to orgasm.
    Newer thought of myself as depressed person, but the report indicate that I may be depressed.
    Well, not newer, when I was low on testosterone I was depressed no question about that one.

    My biggest concern, now, the remedial supplements support cancer.
    Other places narrow the cancer to melanoma, but I could use strong point of view on this.
    Last thing I need is flare-up on my liposarcoma, that 2 years after surgery behaves very nicely,
    per doctors checkups.
    ------------------------------------------------------------------------------------------
    Opinions about above test are mine and I see this type of report for the first time,
    so I may be missreading some or all of it.
    Attached Images Attached Images          

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    What did i tell you that your gluthione levels were low !!
    And that why i suggested GLuthione push 3 grams for 1 week then 6 grams next week then 10 grams per week !! Your detoxfication pathways are screwed up mainly gluthione. Which means NAC 600 mgs BID should help bring this up as well as P5P 50 mgs BID, i have an idea your gluthione levels where low is because of your low e2 from the liquidex..Your serotonin levels and dopamine levels are in the toilet and you may need folonic acid vs folic acid. It all comes back to improper methylation of the liver as I have been stressing over and over over again.. TMG is diverting pathways from folic acid pathways, CBS pathways Your iron levels are scrweing up your dopamine production which is easily visible if you look at the flow path. Ok when you get your estorgen test back want to make a bet that you methylated estrogen are low !!! if your gluthione levels are they go hand in hand majority of the time. NEED FOR SOME SAM-E NOT TMG !! SCrewing around with estrogen blockers probably did you in. When you get urine test back I bet e2 is almost undectable !!
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    Quote Originally Posted by hardasnails1973 View Post
    What did i tell you that your gluthione levels were low !!
    And that why i suggested GLuthione push 3 grams for 1 week then 6 grams next week then 10 grams per week !! Your detoxfication pathways are screwed up mainly gluthione. Which means NAC 600 mgs BID should help bring this up as well as P5P 50 mgs BID, i have an idea your gluthione levels where low is because of your low e2 from the liquidex..Your serotonin levels and dopamine levels are in the toilet and you may need folonic acid vs folic acid. It all comes back to improper methylation of the liver as I have been stressing over and over over again.. TMG is diverting pathways from folic acid pathways, CBS pathways Your iron levels are scrweing up your dopamine production which is easily visible if you look at the flow path. Ok when you get your estorgen test back want to make a bet that you methylated estrogen are low !!! if your gluthione levels are they go hand in hand majority of the time. NEED FOR SOME SAM-E NOT TMG !! SCrewing around with estrogen blockers probably did you in. When you get urine test back I bet e2 is almost undectable !!
    HAN, no disrespect to you, but:

    on page #8 there are sugestions from Genova on what to take.
    I retyped them on spreadsheet (and attached as page #9) and figured out of what I would take if I bought those supplements from LEF.

    What do you think of their suggestions?
    ============================== ==============
    Their suggestions repeated:

    L-phenylalanine 500-2000 mg/d
    L-thyrosine 500-2000 mg/d
    Copper 2-4 mg/d
    L-metionine 500-100mg/d
    Magnesium 100-200 mg/d
    B2 5-50mg/d
    Molybdenum 50-250 μg/d,
    additionally they suggest detoxification, I am not sure what actions I would have to take on that
    ============================== ==============
    and I worry because all three L's are cancer friendly

    L-phenylalanine
    L-thyrosine
    L-metionine
    ============================== ==============
    I will try to sumarize your current suggestions,
    convert them to LEF products
    and ask you to check if I got them right.
    But that will be latter, hope you do not mind.

    My head is spinning little bit, this is all new to me.
    .
    .
    .
    Attached Files Attached Files
    •   
       

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    Quote Originally Posted by JanSz View Post
    HAN, no disrespect to you, but:

    on page #8 there are sugestions from Genova on what to take.
    I retyped them on spreadsheet (and attached as page #9) and figured out of what I would take if I bought those supplements from LEF.

    What do you think of their suggestions?
    ============================== ==============
    Their suggestions repeated:

    L-phenylalanine 500-2000 mg/d
    L-thyrosine 500-2000 mg/d
    Copper 2-4 mg/d
    L-metionine 500-100mg/d
    Magnesium 100-200 mg/d
    B2 5-50mg/d
    Molybdenum 50-250 μg/d,
    ============================== ==============
    and I worry because all three L's are cancer friendly

    L-phenylalanine
    L-thyrosine
    L-metionine
    ============================== ==============
    I will try to sumarize your current suggestions,
    convert them to LEF products
    and ask you to check if I got them right.
    But that will be latter, hope you do not mind.

    My head is spinning little bit, this is all new to me.
    Primary things first
    1. gluthione Push 3 grams start
    2. 4000 mcgs folonic acid - cancer people have problems converting folic acid to active form
    3 5,000 mcgs methycobalin - cancer patience can not convert b-12 to active form
    4. 400 mgs b-2
    5. coenzyme q 10- 100-200 mgs
    6 coenzyme b sublgual - YOU ARE A SLOW CONVERTER !!
    why low citric acid level. Citric acid level can be increases by apple cider vinegar and lemon juice with your water as well as AKG .. People with low citric acid have slowed kreb cycles..as you can see malic acid is available in apples
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    This is mostly over my head, but I'll make a few comments:

    1. I'm not sure that sweating a lot in the workout is a problem. Sometimes I sweat a lot i.e. when it's hot. However, I don't have any less energy on those days.

    2. I'm taking 5-HTP for Serotonin support.

    3. I'm taking Excita Plus https://www.neurorelief.com/index.ph...=103&Itemid=47 for Dopamine support. The main ingredient seems to me Macuna Pruriens bean extract which contains 50% L-Dopa

    Mark
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    Quote Originally Posted by MarkLA View Post
    This is mostly over my head, but I'll make a few comments:

    1. I'm not sure that sweating a lot in the workout is a problem. Sometimes I sweat a lot i.e. when it's hot. However, I don't have any less energy on those days.

    2. I'm taking 5-HTP for Serotonin support.

    3. I'm taking Excita Plus https://www.neurorelief.com/index.ph...=103&Itemid=47 for Dopamine support. The main ingredient seems to me Macuna Pruriens bean extract which contains 50% L-Dopa

    Mark
    AS i stated before estrogen is needed to transport copper, serotonin production as well as dopamine, proper methylation, glutething production. Tinkering around with anti estrogens will cause a copper biodefiecncy as well as lower ferritin levels. Need I say more


    A crucial role for thiol antioxidants in estrogen-deficiency bone loss

    NIH Guide: DIET, DNA METHYLATION AND OTHER EPIGENETIC EVENTS, AND CANCER PREVENTION

    DNA hypomethylation, cancer, the immunodeficiency,...[J Nutr. 2002] - PubMed Result

    Factors Influencing Serum Copper and Ceruloplasmin Oxidative Activity in the Rat -- Meyer et al. 194 (3): 581 -- AJP - Legacy
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    HAN, I have to make a list of all separate items that you have mentioned on your posts on this thread,
    some of them I am already taking some have no idea of what they are.
    Hopefully I can make a sensible list before I see my doc.
    So far I think you are after implementing what Genova summarized under name of Detoxification, I think.
    Would this detox be a project for couple weeks only or is this for life?


    Do you have a comments on the stuff that Genova suggested:
    specially
    L-phenylalanine
    L-thyrosine
    L-metionine

    all three are available from LEF, I am just uneasy with making a purchase.
    ============================== ============================
    Mega L-Glutathione Caps
    250 mg, 60 capsules
    Item Catalog Number: 314
    Mega L Glutathione, 250 Mg 60 Capsules Twinlab
    3 grams for 1 week then 6 grams next week then 10 grams per week !!
    that translates to
    6 pills/day first week
    40 pills/day next week
    discontinue after second week, right?

    there is intravenous Glutathione available, should I ask for that??
    ============================== ===========================
    NAC 600 mgs BID

    I am already taking N-acetyl-L-cysteine (NAC) 200mgs/2xday=400mg/day
    ============================== ===========================
    P5P 50 mgs BID,

    pyridoxal-5'-phosphate (P5P)

    I am already taking with my multivitamins:
    Vitamin B6 (as pyridoxine HCI with 2.5 mg pyridoxal 5’phosphate coenzyme)--100 mg/day
    ============================== ============================== =========
    Your iron levels .......................

    my ferritin is low
    Ferritin=28(20-380)ng/dL---LEFrange(50-150)
    I got today
    Iron Protein Plus
    300 mg, 100 capsules
    Item Catalog Number: 563
    Iron Protein Plus, 300 Mg 100 Capsules
    I am so mad at myself.
    In 2001 another doc, after doing hair analysis, told me to use iron.
    I did but latter stopped, I newer had it connected with ferritin until now.

    How many of this pills should I take?
    Half hour ago I took first one.
    ============================== ============================== ========
    Source Naturals, MegaFolinic, 800 mcg, 120 Tablets
    MegaFolinic, 800 mcg, 120 Tablets
    5 tablets daily
    ============================== ============================== ========
    5,000 mcgs methycobalin
    My blood test
    Vitamin B12, serum=1248(200-1100)pg/mL
    I think I can skip this one.
    ============================== ============================== ========
    400 mgs b-2
    see above on P5P
    ============================== ============================== ========
    coenzyme q 10- 100-200 mgs
    already taking
    ============================== ============================== ========
    coenzyme b sublgual - YOU ARE A SLOW CONVERTER !!
    I am not sure if this one would fit the bill, not sure if it is sublingual.
    NOW FOODS , Co-Enzyme B-Complex With Alpha Lipoic Acid and CoQ10, 60 Tablets
    ============================== ============================== ========
    I do not think I can eat more appless.
    Actually I am sure I eat too many apples to the detriment of other food.
    ============================== ============================== ========
    I am already taking one pill/day
    SAMe (S-adenosyl-methionine)
    200 mg, 50 enteric coated tablets
    and
    2 pills TMG
    500 mg, 180 tablets

    help in adjusting dose

    ============================== ============================== ========
    My EstroEssence test got lost, that is how it looks now. I will have to start from scratch on it.
    ============================== ============================== ========
    HAN advised here
    Forget the RX for this
    HepatoPro (Polyunsaturated Phosphatidylcholine)
    900 mg, 60 capsules
    Item Catalog Number: 656
    Hepatopro, 900 Mg 60 Capsules

    ============================== ============================== ========
    MarkLA is taking:

    5-HTP for Serotonin support
    and
    ExcitaPlus
    Excitatory neurotransmitter support
    https://www.neurorelief.com/index.ph...=103&Itemid=47
    ============================== ============================== ========
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    Quote Originally Posted by hardasnails1973 View Post
    What did i tell you that your gluthione levels were low !!
    And that why i suggested GLuthione push 3 grams for 1 week then 6 grams next week then 10 grams per week !! Your detoxfication pathways are screwed up mainly gluthione. Which means NAC 600 mgs BID should help bring this up as well as P5P 50 mgs BID, i have an idea your gluthione levels where low is because of your low e2 from the liquidex..Your serotonin levels and dopamine levels are in the toilet and you may need folonic acid vs folic acid. It all comes back to improper methylation of the liver as I have been stressing over and over over again.. TMG is diverting pathways from folic acid pathways, CBS pathways Your iron levels are scrweing up your dopamine production which is easily visible if you look at the flow path. Ok when you get your estorgen test back want to make a bet that you methylated estrogen are low !!! if your gluthione levels are they go hand in hand majority of the time. NEED FOR SOME SAM-E NOT TMG !! SCrewing around with estrogen blockers probably did you in. When you get urine test back I bet e2 is almost undectable !!
    NEED FOR SOME SAM-E NOT TMG !!

    HAN
    what are you saying?

    I am taking

    2 tablets TMG 500 mg,
    and
    2 tablets Super BioActive CoQ10 Ubiquinol50 mg


    Do you want me to drop TMG and increase CoQ10??
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    Quote Originally Posted by JanSz View Post
    NEED FOR SOME SAM-E NOT TMG !!

    HAN
    what are you saying?

    I am taking

    2 tablets TMG 500 mg,
    and
    2 tablets Super BioActive CoQ10 Ubiquinol50 mg


    Do you want me to drop TMG and increase CoQ10??
    TMG steals the pathway of methyation from b-12 and folic acid so methyation gets divertedfrom methione synthase pathway to BMHT (TMG/choline). That why first step in repairing methyation is injectable methy b-12 with folininc acid. This treat meant is used in autism ..200 mgs sam-2 is not going to do crap. Need 200 BID and after 3 days 400 BID your liver is severly undermethyated from the cancer. or more so hidden undermethyation was the root cause of your cancer

    Here hill 4 birds with one stone
    http://www.cerefolin.com/
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    Quote Originally Posted by hardasnails1973 View Post
    TMG steals the pathway of methyation from b-12 and folic acid so methyation gets divertedfrom methione synthase pathway to BMHT (TMG/choline). That why first step in repairing methyation is injectable methy b-12 with folininc acid. This treat meant is used in autism ..200 mgs sam-2 is not going to do crap. Need 200 BID and after 3 days 400 BID your liver is severly undermethyated from the cancer. or more so hidden undermethyation was the root cause of your cancer

    Here hill 4 birds with one stone
    Neurovascular Oxidative Stress and/or Hyperhomocysteinemia : CerefolinNAC
    """"2 tablets TMG 500 mg,
    and
    2 tablets Super BioActive CoQ10 Ubiquinol50 mg""""""

    I am refilling my supplements for the next 18 days.

    I will skip TMG
    increase SAME to 4 pills
    ============================== =====================
    ============================== =====================
    To others I have standard advice for dealing with other than E2 estrogens.
    2 tabs TMG
    4 tabs DualAction--->now Breast Formula
    2 tabs Resveratrol
    calcium glutharate.

    How should I modify this list?
    More often then not there is no supporting information but one would wish to provide advice that have at least good chance at being helpful.
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    Quote Originally Posted by JanSz View Post
    """"2 tablets TMG 500 mg,
    and
    2 tablets Super BioActive CoQ10 Ubiquinol50 mg""""""

    I am refilling my supplements for the next 18 days.

    I will skip TMG
    increase SAME to 4 pills
    ============================== =====================
    ============================== =====================
    To others I have standard advice for dealing with other than E2 estrogens.
    2 tabs TMG
    4 tabs DualAction--->now Breast Formula
    2 tabs Resveratrol
    calcium glutharate.

    How should I modify this list?
    More often then not there is no supporting information but one would wish to provide advice that have at least good chance at being helpful.
    main problem methylation sam-e is best rouet for that
    dropping the TMG to may be 500 mgs a day or dump it totally
    keep lugols in 3-4 drops 2 drops 8 hours apart

    use cerefolin
    methyl b-12 5,000 mcgs
    4000 mgs folonic acid -
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    Quote Originally Posted by hardasnails1973 View Post
    main problem methylation sam-e is best rouet for that
    dropping the TMG to may be 500 mgs a day or dump it totally
    keep lugols in 3-4 drops 2 drops 8 hours apart

    use cerefolin
    methyl b-12 5,000 mcgs
    4000 mgs folonic acid -
    I am going to drop Lugols.
    I started on
    Breast Health Formula
    it contains
    Iodine (as potassium iodide) 2 mg (miligrams)
    Looking for Iodine I just realized I am taking about
    50mcg of Iodine (as potassium iodide)
    with my multivitamins.

    (HAN take closer look at this Breast Health Formula)

    Also about Vit B12, I have more than enough of it in the blood.
    Vitamin B12, serum=1248 (200-1100)pg/mL
    so I need something to transport it.
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    Quote Originally Posted by JanSz View Post
    I am going to drop Lugols.
    I started on
    Breast Health Formula
    it contains
    Iodine (as potassium iodide) 2 mg (miligrams)
    Looking for Iodine I just realized I am taking about
    50mcg of Iodine (as potassium iodide)
    with my multivitamins.

    (HAN take closer look at this Breast Health Formula)

    Also about Vit B12, I have more than enough of it in the blood.
    Vitamin B12, serum=1248 (200-1100)pg/mL
    so I need something to transport it.
    cancer patients need up 50 -100 mgs of iodoral a day !!
    You need to convert it !! if you are showing possible low functionalt b-12 it measn that its not converting to methy b-12 because lack of folic acid (folonic acid) active form people with cancer are under converters or slow converters. both need to be address best in a 1:1 ratio methyl b-12 to folonic acid.
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    Quote Originally Posted by hardasnails1973 View Post
    cancer patients need up 50 -100 mgs of iodoral a day !!
    You need to convert it !! if you are showing possible low functionalt b-12 it measn that its not converting to methy b-12 because lack of folic acid (folonic acid) active form people with cancer are under converters or slow converters. both need to be address best in a 1:1 ratio methyl b-12 to folonic acid.
    Till few days ago, when I got this Breast Heath Formula, I was consuming 6-8 drops of Lugol's Solution daily.
    I like Lugol's, how many drops should I take to make it equal to (50-100)mgs of Idoral?
    ============================== =================
    You are harping at Vit B12 (plenty of it in the blood) and you want me to take folonic acid).
    That gets me to my blood test 4/13/07
    Homocysteine, cardio=6.9(<11.4)MICROmol/L (LEF(<7.2)

    so I am kind of close on Homocysteine now,
    but I used to be over the LEF range in the past.

    Now, LEF have a product called
    Homocysteine Resist
    100 capsules
    Item Catalog Number: 800
    Homocysteine Resist, 100 Capsules

    It contains:
    Vitamin B6 (as pyridoxine HCI) 750 mg
    Folate (as folic acid) 800 mcg
    Vitamin B12 (as cyanocobalamin) 500 mcg

    Should I go for this one?
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    Quote Originally Posted by JanSz View Post
    Till few days ago, when I got this Breast Heath Formula, I was consuming 6-8 drops of Lugol's Solution daily.
    I like Lugol's, how many drops should I take to make it equal to (50-100)mgs of Idoral?
    ============================== =================
    You are harping at Vit B12 (plenty of it in the blood) and you want me to take folonic acid).
    That gets me to my blood test 4/13/07
    Homocysteine, cardio=6.9(<11.4)MICROmol/L (LEF(<7.2)

    so I am kind of close on Homocysteine now,
    but I used to be over the LEF range in the past.

    Now, LEF have a product called
    Homocysteine Resist
    100 capsules
    Item Catalog Number: 800
    Homocysteine Resist, 100 Capsules

    It contains:
    Vitamin B6 (as pyridoxine HCI) 750 mg
    Folate (as folic acid) 800 mcg
    Vitamin B12 (as cyanocobalamin) 500 mcg

    Should I go for this one?
    GEt iodine tested its cheap and its accurate. Cancer people may have a hard time uptaking it due to defects in NIS
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    Quote Originally Posted by hardasnails1973 View Post
    GEt iodine tested its cheap and its accurate. Cancer people may have a hard time uptaking it due to defects in NIS
    Will do iodine test on my next test.
    Thank you.
    What about guess about approximate dose of Lugol's, now?
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    Quote Originally Posted by JanSz View Post
    Will do iodine test on my next test.
    Thank you.
    What about guess about approximate dose of Lugol's, now?
    3-4 drops BID 8 hours apart takes about 6 months to get fully saturated

    Iodine Supplementation Protocol - To Be Used Under Medical Supervision
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    Quote Originally Posted by hardasnails1973 View Post
    3-4 drops BID 8 hours apart takes about 6 months to get fully saturated

    Iodine Supplementation Protocol - To Be Used Under Medical Supervision
    I am taking that much (probably slightly more) since about February this year, when discussion about iodine started.
    By now I have used about 25mL of my 30mL bottle of Lugol's solution.
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    Well, yesterday I dropped at doctor's office the questionaire from Nutrition company.
    CustomVite.Com - Personalized Nutritional Supplements
    CustomVite
    Will see what they advice.
    They are working based on
    Metabolic Analysis and Cellular Energy
    Estrogen Metabolism Plus
    Hair analysis from 2004
    Blood tests
    and their questionaire.
    ============================== ============================== ====================

    Something fishy.
    October 16 I got phone from Genova about age of my Estroessence urine sample. Well, I told them that I

    produced that sample on Oct 1, so it was 16 days old. She told me that it was too old. So I arranged for next

    Estroessence kit, being determined to get this test. I am still waiting for the kit.
    Yesterday, Oct 30, at doctors office I see that Genova must heve used that sample and produced Estrogen

    Metabolism Plus, not complete Estroessence.
    I have my doubts about quality of this test, but have copies attached to this post.
    ============================== ============================== ====================
    My 2/16 is low but it is within range, my 2/16=1.0 (0.61-7.53)
    Some of other estrogens are not calculated (too low).
    I am surprised about suggested corrective action.
    Sample report
    http://www.gdx.net/images/reportpdf/EstroEssence.pdf

    says that the 2/16 less than 2.0 should be treated with:
    "indole-3-carbinols from cruciferous vegetables, flaxseed, soy, omega-3 fatty acids, and exercise"
    but my report recomends using:
    ---------------
    TMG - trimethylglycine (betaine)
    folate, B6, B12, Magnesium
    methionine
    ---------------
    There is no recomendation on dose size or range,
    so the advice is less detailed than in the Metabolic Panel.
    -----------------
    I see where this is going.
    The advice is similar as one would get having high homocysteine.
    My (blood test) Homocysteine=6.5(<11.4)(LEF have 6.8 as cut off point)
    I thought that I was ok.
    But when Homocysteine is high, LEF recomends:

    Homocysteine Resist
    100 capsules
    Item Catalog Number: 800
    Homocysteine Resist, 100 Capsules

    Serving Size 1 capsule
    Servings Per Container 100
    Amount Per Serving
    Vitamin B6 (as pyridoxine HCI) 750 mg
    Folate (as folic acid) 800 mcg
    Vitamin B12 (as cyanocobalamin) 500 mcg
    ============================== =========================

    So it looks like based on this Estrogen Metabolism test I will be adding
    Homocysteine Resist, 1pill/day
    TMG, not sure how much
    methionine (repetition from Metabolic test)
    ============================== ================
    From Metabolic panel I already have recomendation to use
    L-phenylalanine 500-2000 mg/d
    L-thyrosine 500-2000 mg/d
    L-methionine 500-1000mg/d
    Detoxification
    B2 5-50mg/d
    Molybdenum 50-250 μg/d,
    ============================== ============================== ======================
    Translating into LEF products the following supplements should cover advice I got from all three tests on this

    thread.

    Homocysteine Resist, 1pill/day

    TMG, not sure how much

    D,L-Phenylalanine Capsules 500 mg, 100 capsules Item Catalog Number: 034
    Dl Phenylalanine, 500 Mg 100 Capsules

    L-Tyrosine 500 mg, 100 tablets Item Catalog Number: 326
    L-Tyrosine, 500 Mg 100 Tablets: Source Naturals

    L-Methionine Powder 100 grams Item Catalog Number: 130
    Methionine, 100 Grams Powder

    To get Molybdenum I would take-------
    Only Trace Minerals 90 capsules Item Catalog Number: 717
    Only Trace Minerals, 90 Capsules

    Recomended (B2 5-50mg/d) I will skip, I already use about 30-40mg/day of B2
    (or should I increase dosage??)
    ============================== ============================== ======================
    I am waiting now for the advice that the CustomVite will give me.

    I the mean time I am still waiting for the kits so I could start
    Estroessence
    and
    Essential and Metabolic Fatty Acids Analysis
    now thinking of may be adding to my collection of tests:
    Comprehensive Digestive Stool Analysis (CDSA)
    ============================== ============================== =====
    Attached Images Attached Images   
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    Quote Originally Posted by JanSz View Post
    Well, yesterday I dropped at doctor's office the questionaire from Nutrition company.
    Will see what they advice.
    They are working based on
    Metabolic Analysis and Cellular Energy
    Estrogen Metabolism Plus
    Hair analysis from 2004
    Blood tests
    and their questionaire.
    ============================== ============================== ====================

    Something fishy.
    October 16 I got phone from Genova about age of my Estroessence urine sample. Well, I told them that I

    produced that sample on Oct 1, so it was 16 days old. She told me that it was too old. So I arranged for next

    Estroessence kit, being determined to get this test. I am still waiting for the kit.
    Yesterday, Oct 30, at doctors office I see that Genova must heve used that sample and produced Estrogen

    Metabolism Plus, not complete Estroessence.
    I have my doubts about quality of this test, but have copies attached to this post.
    ============================== ============================== ====================
    My 2/16 is low but it is within range, my 2/16=1.0 (0.61-7.53)
    Some of other estrogens are not calculated (too low).
    I am surprised about suggested corrective action.
    Sample report
    http://www.gdx.net/images/reportpdf/EstroEssence.pdf

    says that the 2/16 less than 2.0 should be treated with:
    "indole-3-carbinols from cruciferous vegetables, flaxseed, soy, omega-3 fatty acids, and exercise"
    but my report recomends using:
    ---------------
    TMG - trimethylglycine (betaine)
    folate, B6, B12, Magnesium
    methionine
    ---------------
    There is no recomendation on dose size or range,
    so the advice is less detailed than in the Metabolic Panel.
    -----------------
    I see where this is going.
    The advice is similar as one would get having high homocysteine.
    My (blood test) Homocysteine=6.5(<11.4)(LEF have 6.8 as cut off point)
    I thought that I was ok.
    But when Homocysteine is high, LEF recomends:

    Homocysteine Resist
    100 capsules
    Item Catalog Number: 800
    Homocysteine Resist, 100 Capsules

    Serving Size 1 capsule
    Servings Per Container 100
    Amount Per Serving
    Vitamin B6 (as pyridoxine HCI) 750 mg
    Folate (as folic acid) 800 mcg
    Vitamin B12 (as cyanocobalamin) 500 mcg
    ============================== =========================

    So it looks like based on this Estrogen Metabolism test I will be adding
    Homocysteine Resist, 1pill/day
    TMG, not sure how much
    methionine (repetition from Metabolic test)
    ============================== ================
    From Metabolic panel I already have recomendation to use
    L-phenylalanine 500-2000 mg/d
    L-thyrosine 500-2000 mg/d
    L-methionine 500-1000mg/d
    Detoxification
    B2 5-50mg/d
    Molybdenum 50-250 μg/d,
    ============================== ============================== ======================
    Translating into LEF products the following supplements should cover advice I got from all three tests on this

    thread.

    Homocysteine Resist, 1pill/day

    TMG, not sure how much

    D,L-Phenylalanine Capsules 500 mg, 100 capsules Item Catalog Number: 034
    Dl Phenylalanine, 500 Mg 100 Capsules

    L-Tyrosine 500 mg, 100 tablets Item Catalog Number: 326
    L-Tyrosine, 500 Mg 100 Tablets: Source Naturals

    L-Methionine Powder 100 grams Item Catalog Number: 130
    Methionine, 100 Grams Powder

    To get Molybdenum I would take-------
    Only Trace Minerals 90 capsules Item Catalog Number: 717
    Only Trace Minerals, 90 Capsules

    Recomended (B2 5-50mg/d) I will skip, I already use about 30-40mg/day of B2
    (or should I increase dosage??)
    ============================== ============================== ======================
    I am waiting now for the advice that the Nutrition company will give me.
    Already forgot their name.
    I the mean time I am still waiting for the kits so I could start
    Estroessence
    and
    Essential and Metabolic Fatty Acids Analysis
    now thinking of may be adding to my collection of tests:
    Comprehensive Digestive Stool Analysis (CDSA)
    ============================== ============================== =====
    If this test is correct and valid you are severely undermethyated. One can have normal homocystein levels and still be undermethyated. Amino acid urine would tell what pathway is being used. If you use the TMG then the b-12/folate pathways will be down regulated and that is where80% of the methyation takes place. TMG is only 20% and is only a back up.

    Your key is to identify where the imbalance is occuring in the liver which on of the pathways
    1. BHMT
    2. CBS
    3. methione synthase.

    These results you reflect your BPH big time.

    So I would go full bore on
    400-600 mgs of DIM pro or biodim
    1 cc methycolablin shots every 3rd day
    1 sublgual 5000 mcg mehy b-12
    8000 mgs folonic acid - metagenics folapro
    800 mgs mageisum
    900 mgs phosphodyl choline.

    personally i think you tinkering with e2 is altering liver pathway and methyation
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    Quote Originally Posted by hardasnails1973 View Post
    If this test is correct and valid you are severely undermethyated. One can have normal homocystein levels and still be undermethyated. Amino acid urine would tell what pathway is being used. If you use the TMG then the b-12/folate pathways will be down regulated and that is where80% of the methyation takes place. TMG is only 20% and is only a back up.

    Your key is to identify where the imbalance is occuring in the liver which on of the pathways
    1. BHMT
    2. CBS
    3. methione synthase.

    These results you reflect your BPH big time.

    So I would go full bore on
    400-600 mgs of DIM pro or biodim
    1 cc methycolablin shots every 3rd day
    1 sublgual 5000 mcg mehy b-12
    8000 mgs folonic acid - metagenics folapro
    800 mgs mageisum
    900 mgs phosphodyl choline.

    personally i think you tinkering with e2 is altering liver pathway and methyation
    I guess you are talking this test from Genova, plese confirm that it is the right test,
    I will order it.
    One problem, they say it is available as urine or blood, should I order both or one of them, which one?

    Amino Acids Analysis
    GDX Amino Acids Analysis
    GDX Amino Acids Analysis Sample Report
    http://www.gdx.net/images/reportpdf/aminoacids.pdf
    GDX Amino Acids Analysis Application Guide

    My blood shows high on B12:
    Vitamin B12, serum=1248(200-1100)pg/mL
    so I am assuming I would not need methycolablin shots or b-12 pills

    I am taking
    Folic acid 800 mcg
    possibly I do not need folinic
    for whatewer reason LEF do not carry folonic anymore.


    I am taking
    Magnesium (as magnesium oxide, citrate, glycinate,taurinate, arginate, ascorbate)=400 mg
    and
    Magnesium (as magnesium oxide)=340 mg

    I just started
    HepatoPro (Polyunsaturated Phosphatidylcholine)
    Polyenylphosphatidylcholine= 900 mg
    ============================== ============================== ============================== ==
    GDX Amino Acids Analysis Application Guide
    Urine versus Plasma
    The body fluids that are most commonly assessed for amino acid content are urine from a 24-hour collection and plasma following an overnight fast. 24-hr urine amino acid measurements show what is high and what is low over a 24-hr period, provided that renal function is reasonably normal. In contrast, blood plasma amino acid measurements show the levels of amino acids that are being transported at a point in time.

    There are several advantages to starting with a 24-hour urine analysis. Urine analysis reveals more distinctive patterns related to problems in enzymatic activity, nutrient cofactor adequacy, and transport. Urine is also not subject to the circadian rhythm variation in amino acids that is present in blood, and excesses or deficiencies over a period of time can be more easily assessed. Many conditions of amino acid wasting, e.g. cystinuria, are thus identifiable in urine samples. Due to renal conservation of amino acids, urine levels typically drop before plasma levels. For these reasons, a 24-hour urine is more likely to reveal marginal deficiencies. Only severe deficiencies will result in low values on both tests.

    Plasma amino acids analysis may be preferred when age, toilet training, behavior, or patient cooperation present as complicating factors. Other possible reasons for selecting plasma analysis include severe malnutrition, anorexia, hematuria conditions (including menstruation), and rheumatoid arthritis, where the common pattern of low histidine only shows in a plasma sample. If poor renal clearance or renal failure is known beforehand, a blood plasma analysis is recommended. Also, in urinary wasting conditions or in nephrotic syndromes, the plasma levels are indicative of status while the urine levels serve to confirm the diagnosis.

    For plasma sampling, an overnight, fasting measurement is conventional practice. Such sampling reduces dietary influences and accentuates metabolic status.

    A comprehensive workup to assess the gross metabolic state would include both urine and plasma analyses, measured in the same time period, particularly for the patient with degenerative disease or with severe intolerances to foods or environmental substances. If a choice must be made because of cost or other factors, urine is preferred.
  22. Professional Member
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    HAN;

    I have made a list of all my supplements and medicines that I am taking.
    I had to do it to attach it to the CustomVite questionare I was filling up.

    It is on Excel file, but I had to zip it because our board do not recognize Excel.

    I can insert Excel file into Word file if that could be of any help.

    It is really a lot of supplements that I am taking.
    If you have a time and are willing, please look at it and tell me if you see that something there is hurting me.

    IIRC that list do not have the HepatoPro,
    Polyenylphosphatidylcholine= 900 mg
    that I started taking.

    Thank you.

    EDITED;
    I posted the attachment in original, Excel format, here:
    Anabolic Steroids and Bodybuilding - View Single Post - What Supplements are you taking
    Attached Files Attached Files
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    Quote Originally Posted by JanSz View Post
    HAN;

    I have made a list of all my supplements and medicines that I am taking.
    I had to do it to attach it to the CustomVite questionare I was filling up.

    It is on Excel file, but I had to zip it because our board do not recognize Excel.

    I can insert Excel file into Word file if that could be of any help.

    It is really a lot of supplements that I am taking.
    If you have a time and are willing, please look at it and tell me if you see that something there is hurting me.
    When doing an amino acid urine stop all supplements other then meds 3 days prior to see what your body requires rather then supplemented

    IIRC that list do not have the HepatoPro,
    Polyenylphosphatidylcholine= 900 mg
    that I started taking.

    Thank you.
    Yes i can not open it
    That is the rigth amino acid test I bet you uncoverse a fuctional folic acid defieincy as it did me and your sarconsine is elevated as well as another indicator

    If my hunch is correct if you correct the undermethyation then alot of your symptoms should be addressed as well. underemthyation causes low thyroid, low adrenals and low testosterone..
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    Quote Originally Posted by hardasnails1973 View Post
    Yes i can not open it
    That is the rigth amino acid test I bet you uncoverse a fuctional folic acid defieincy as it did me and your sarconsine is elevated as well as another indicator

    If my hunch is correct if you correct the undermethyation then alot of your symptoms should be addressed as well. underemthyation causes low thyroid, low adrenals and low testosterone..
    HAN;
    I posted that same file, just in original Excel form,
    on the other board, here:

    http://forum.mesomorphosis.com/566502-post10.html

    please review it if you have a time.

    If you cannot read Excel;
    I can make it into Word document.
    If everything else fails I can post it directly, but that would very hard to read.
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    Waiting for my new tests to come.


    I have a big dillema with this old one.
    on page 8
    my test is advising me to take
    Magnesium (100-200)mg/day

    I have popo this until now because I am taking tonns of Magnessium and my blood test shows that my Magnesium is ok.

    But now I have missgivings, I have similar situation with B12,
    but I have increased B12 (without arguing much).

    Now I am not sure.
    Because I now noted that they are concern enough about Magnessium that they want me to do (red blood cell)
    RBC elemental analysis to figure out my Mg status.
    Actually the want that for copper, magnesium and molybdenum.

    Molybdenum levels I do not know but I just changed my multivitamins because I had too much copper.
    ============================== ==========

    In few places Genova is warning about large differences between average good levels and their testing that shows "functional" needs.
    ============================== ===========

    Blood draw 4/13/2007 Quest Diagnostics

    1 Calcium=9.7(8.5-10.4)mg/dL
    2 Carbon dioxide=28(21-33)nmol/L
    3 Chloride=28(21-33) nmol/L
    4 Copper, serum=1856(590-1180)mcg/L
    5 Ferritin=54(20-380)ng/mL
    6 Magnesium=1.95(1.50-2.50)mg/dL
    7 Potasium=4.5(3.5-5.3)nmol/L
    8 Selenium=176(110-160)mcg/L
    9 Sodium=144(135-146)nmol/L
    10 Zinc=1051(670-1240)mcg/L
    ============================== =============

    I take this much Magnesium with my supplements

    Vitamin C (as ascorbic acid, calcium ascorbate, ascorbyl palmitate, magnesium ascorbate, niacinamide) -- 2000 mg

    Magnesium (as magnesium oxide, citrate, glycinate, taurinate, arginate, ascorbate) 400 mg

    Magnesium (as magnesium oxide) 340 mg



    So I take already at least 740mg
    and they want additional 200mg
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    Jan,

    Who ordered those tests for you? How much did the NutrEval cost?

    This is all very interesting and I think I want to get this done for me.

    Thanks,
    WF
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    Quote Originally Posted by wildfox View Post
    Jan,

    Who ordered those tests for you? How much did the NutrEval cost?

    This is all very interesting and I think I want to get this done for me.

    Thanks,
    WF
    My doc steered me in this direction.
    Because of him I have done the test in title of this thread.

    But as I am studying the subject I see that there are other tests.

    It is not exactly easy to navigate Genova web site, so when
    I decided to do more testing I did not ordered what I would today. Last week I send my samples for testing, I had to make decission at some point.

    But as of today I suggest:

    ============================== ==============

    NutriEval (saliva, urine, blood)
    and
    EstroEssence (first morning urine)
    possibly also
    Comprehensive detoxification Profile.

    Also spend 2x $20 and study how to read and apply top two tests.
    PROLibraries.com - Online Professional Education
    -----------------------------------------------------------
    NutrEval discussed
    EW04 - NUTRITIONAL EVALUATION: Understanding Your Patient's Supplement Needs
    A4M :: Conference Library
    A4M :: Conference Library
    Conference: A4M Las Vegas 2006
    Speaker: Patrick Hanaway, MD
    December 7, 2006 6:00 pm - 9:00 pm
    ---------------------------------------------------------
    Estroessence discussed:

    GS02m - Estrogen Metabolism: Modifying Risk in Clinical Practice
    Conference: A4M Orlando 2006
    Speaker: Patrick Hanaway MD
    Length: 31m 07s - 66 Slides
    April 9, 2006 5:00 pm - 5:40 pm
    --------------------------------------------------

    In UK Genova tests are available for the money, no script required.


    NutriEval cost about 550 or so pounds.

    Welcome

    Our Tests

    Some tests have slightly different names.

    Pricing
    Description
    (RRP) Price
    NutrEval Profile �550
    NutrEval PLUS Profile �650
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    Place for my ONE results, pages 1-10
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    Place for my ONE results, pages 11-13
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    Place for my Essential Fatty Acid Metabolism
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    Place for my EstroEssence test results.

    ENZYMES IN SIGNAL TRANSDUCTION PATHWAYS
    Enzymes in STP
    .
    .
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    MTHFR (Intervention)
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    This post is a place maker, please do not respond, thank you.
    Hair Analysis, paid out of pocket, insurance is not covering it, $50.40
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    Hey this is confusing me. I recently had a NutrEval test done which showed very similar results: raised Formiminoglutamic Acid, Low Pyroglutamic Acid, but also showed Raised 5-HIAA, a deficiency of Glycine, Mildly elevated Phenylalanine, & raised Cystein (with low cystine). I was recommended to take the following treatment protocol every day:
    Methylcobalamin - 500mcg (From Higher Nature 'Cardio' supplement)
    Hydroxycobalamin - 1000mcg
    Pyridoxal HCL / P-5-P - 120mg
    Folic Acid - 1200mg
    Reduced Glutathione - 480mg
    TMG - 1200mg (Also from Higher Nature 'Cardio')

    From what I've been seeing from HAN, it may not be a good idea to supplement TMG. Also, since I do not suffer from cancer (yet) I am wondering if these dosages may be sufficient to correct my methylation problems.
  

  
 

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