Sublingual T?

  1. Sublingual T?


    My compounding pharm says she can do a sublingual T and it would be a better option than injections (for E purposes). I'm currently on 150mg (15 g of T?) of compounded cream with some pregnenelone and DHEA mixed in as well as 300IU of HGC 3xweek. Blood tests haven't shown much of a jump.

    9/17/07 results showed:

    DHT 37.0 25-75 ng/dl
    Total T 348.0 250-1100 ng/dl
    Free T 104.4 35-155 pg/ml
    FSH 1.5 1.6-8.0 mIU/ml
    LH 1.7 1.5-9.3 mIU/ml
    Estradiol 31.0 13-54 pg/ml
    Progesterone 0.6 .1 - 1.2 NG/ml
    gonadotropin releasing hormone 5.2 4.0-8.0 pg/ml

    Overall I feel pretty good - energy good, ADD symptoms way eased but still the pesky libido issues...

    I'm seeing my guy today - any quick recommendations?


  2. Bump...can't believe nobody is curious about a sublingual delivery system?

  3. I'm curious.

    Is the the buccal (sticks on your gum) thing or something else?

    Any info on efficacy, safety?

    How long does it take to absorb?

    Note there's a difference between oral (bad for liver) and sublingual.

    Mark
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  4. Quote Originally Posted by MarkLA View Post
    I'm curious.

    Is the the buccal (sticks on your gum) thing or something else?

    Any info on efficacy, safety?

    How long does it take to absorb?

    Note there's a difference between oral (bad for liver) and sublingual.

    Mark
    Bucculs takes 2 passes through the liver once in the blood stream and majority of the drug is lost. You you have to be given the drops several time a day because bucculs only last about 2-3 hours in the blood stream. She is probably following the pulsing method used by shippen. Honesty you e/t ratio is screwed and may want to look thyroid or adrenal functions before jumping on T

  5. Quote Originally Posted by MarkLA View Post
    I'm curious.

    Is the the buccal (sticks on your gum) thing or something else?

    Any info on efficacy, safety?

    How long does it take to absorb?

    Note there's a difference between oral (bad for liver) and sublingual.

    Mark

    I talked with my doc last night and he said its an option although he still thinks creams then gels are the best. Again, my compounding pharm said, in her opinion, it was a better route to take than injections but many on this board would probably disagree....

  6. Quote Originally Posted by DuncanWA View Post
    My compounding pharm says she can do a sublingual T and it would be a better option than injections (for E purposes). I'm currently on 150mg (15 g of T?) of compounded cream with some pregnenelone and DHEA mixed in as well as 300IU of HGC 3xweek. Blood tests haven't shown much of a jump.

    9/17/07 results showed:

    DHT 37.0 25-75 ng/dl
    Total T 348.0 250-1100 ng/dl
    Free T 104.4 35-155 pg/ml
    FSH 1.5 1.6-8.0 mIU/ml
    LH 1.7 1.5-9.3 mIU/ml
    Estradiol 31.0 13-54 pg/ml
    Progesterone 0.6 .1 - 1.2 NG/ml
    gonadotropin releasing hormone 5.2 4.0-8.0 pg/ml

    Overall I feel pretty good - energy good, ADD symptoms way eased but still the pesky libido issues...

    I'm seeing my guy today - any quick recommendations?
    Get at least SHBG

    Transdermals (if they work) will raise your DHT sky high.
    Then you will have to buy story that such high DHT is good for you.
    You already have a proof that what you are using does not work.
    Use injections.
    Do more tests.
    For what to test look at post #44
    Jan's BloodTest April13/2007

    Your DHT is only in the middle of range, and you are already using T cream.

    If on T shots you will have low DHT you may have to get DHT compounded cream (hard to get) or Androgel (expensive).

    Your DHT may need watching.

  7. Buccal delivery does avoid first pass metabolism that oral doses go through, but as has been said the kinetics aren't good for testosterone in men by this route. The blood levels don't stay high enough for long enough. Dosing would need to be 3 to 4 times daily in most cases, even then I'm not convinced the patient would feel well. We do dose women buccally without problems, but the blood levels maintained don't need to be nearly as high.
  

  
 

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