Non Steroid for TRT

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    Non Steroid for TRT


    The search for alternatives to steroid medications for treating millions of Baby Boomer males with age-related declines in the sex hormone testosterone has led researchers in California to report development of a nonsteroidal compound that shows promise as a new treatment for loss of muscle mass, bone tissue, and other problems linked to low testosterone. .
    In the report, Arjan van Oeveren and colleagues point out that the potential side effects of testosterone, a steroid medication, limit its use to older men with low testosterone levels. Testosterone replacement therapy may increase the risk of prostate cancer and stroke, for instance, and cannot be given orally. People take it via skin patches or rub-on gels.
    The new study describes a nonsteroidal compound that in lab rats attaches to testosterone receptors in cells and triggers the same desired effects as actual testosterone in tests in laboratory animals. In comparison to other testosterone replacement treatments, the compound showed similar improvement in muscle mass and strength while having little effect on the prostate, the researchers say. It also significantly improved bone density and strength in the lab rats.
    This study, "Substituted 6-(1-Pyrrolidine) quinolin-2(1H)-ones as Novel Selective Androgen Receptor Modulators," will appear in the Oct. 18 issue of the ACS' Journal of Medicinal Chemistry.

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    First that I have heard of a SARM. We've talked alot about SERMS.


    Full text of study:

    http://pubs.acs.org/cgi-bin/sample.c...jm070231h.html
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    I've done some quick searches to find a company doing SARM research. Here is what I've found on news.moneycentral.msn.com:
    Ligand Pharmaceuticals Incorporated LGND (the "Company" or "Ligand") today announced that an article authored by a team of Ligand scientists will appear in the October 18th issue of the Journal of Medicinal Chemistry and is also highlighted in a recent press release from the American Chemical Society (ACS).

    The article, entitled "Substituted 6-(1-Pyrrolidine)quinolin-2(1H)-ones as Novel Selective Androgen Receptor Modulators (SARMs)" describes the development of a nonsteroidal compound, LGD-2941 that shows promise as a new treatment for loss of muscle mass, bone tissue and other problems linked to aging.
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    SARMs will be the next big thing. I'm betting they sell as big as Viagra once someone isolates the magic molecules.
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    Quote Originally Posted by bioman View Post
    SARMs will be the next big thing. I'm betting they sell as big as Viagra once someone isolates the magic molecules.

    Like i have been preaching its all about molecular magic and nuclear receptors
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    I'd still rather replace what's missing, not try to substitute with something else.
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    Quote Originally Posted by RPHMark View Post
    I'd still rather replace what's missing, not try to substitute with something else.

    Amen to that, Bro'


    Study done by the people who will be marketing this product?

    Like "studies" done by makers of AndroGel???

    Testosterone side effects... (talkin' about pharmaceutical doses here - NOT steroidal doses as used in BB)... what freakin' side effects?

    This is a joke....

    Testosterone - the bio-identical variety - is just like your body's own hormone... and provides (in pharmaceutical doses) numerous health problems.. not just for gaining muscle or helping libido or helping with EC.

    Thanks... but no thanks!
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    Quote Originally Posted by TJack View Post
    Amen to that, Bro'


    Study done by the people who will be marketing this product?

    Like "studies" done by makers of AndroGel???

    Testosterone side effects... (talkin' about pharmaceutical doses here - NOT steroidal doses as used in BB)... what freakin' side effects?

    This is a joke....

    Testosterone - the bio-identical variety - is just like your body's own hormone... and provides (in pharmaceutical doses) numerous health problems.. not just for gaining muscle or helping libido or helping with EC.

    Thanks... but no thanks!

    The first one is in Phase III trials. The manufacturer is planning to file a NDA in late 2008.
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    GTx inc is planning phaseIII trials on ostarine (SARM).
    Builds muscle,promotes bone strength,enhances libido,increases fertility

    Does not: stimulate prostate cancer,virilization,acne

    What is involved in testing this? Anybody?
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    http://clinicaltrials.gov/

    Usually has the trial, who is running it and what the requirements are. A quick search didn't turn up anything for ostarine, but maybe a more throrough look will turn something up.

    Let us know what you find.
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    Injected testosterone has long term negative effects on future natural testosterone production. Do sarms have the same problem?
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    Merck is underwritting SARMS by GTx.
    http://www.rttnews.com/sp/breakingnews.asp?item=102
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    Quote Originally Posted by RichTan View Post
    Merck is underwritting SARMS by GTx.
    http://www.rttnews.com/sp/breakingnews.asp?item=102

    GTx, Inc., the Men's Health Biotech Company, today announced that ostarine, a first-in-class selective androgen receptor modulator (SARM), met its primary endpoint in a Phase II proof of concept double blind, randomized, placebo controlled clinical trial in 120 subjects...

    (60 elderly men and 60 postmenopausal women)...


    A summary of the topline data is as follows:

    Primary endpoint: total lean body mass (LBM) measured by dual energy x-ray absorptiometry (DEXA) at baseline compared to three months

    -- Among all subjects (n=114), ostarine treatment resulted in a dose dependent increase in total lean body mass, with an increase of 1.3 kg compared to baseline and 1.4 kg compared to placebo (p<0.001) at the 3 mg dose. (Note: This is 2.86 pounds and 3.08 pounds respectively.... for a time period of THREE months... a good diet program and exercise program could have easily beat out those figures!)

    -- Among females (n=56), ostarine treatment resulted in a dose dependent increase in LBM with the 3 mg dose having an increase of 1.7 kg compared to baseline and an increase of 1.4 kg compared to placebo (p=0.02). (Note: That is 3.74 pounds and and 3.08 pounds respectively.... for a time period of THREE months... a good diet program and exercise program could have easily beat out those figures!)

    -- Among males (n=58), treatment with a 1 mg dose of ostarine resulted in a LBM increase of 0.7 kg compared to baseline and an increase of 1.2 kg compared to placebo (p=0.03), and treatment with a 3 mg dose of ostarine resulted in an increase of 1.0 kg compared to baseline and an increase of 1.4 kg compared to placebo (p=0.005). (Note: Simply shows that the drug is highly dose dependant))

    Secondary endpoints: performance, fat mass, bone mineral density, and bone turnover markers

    -- In a stair climb functional performance test that measured speed (time to completion) and power exerted (watts), subjects treated with a 3 mg dose of ostarine demonstrated on average a 15.5% faster time to completion (p=0.006) and exerted on average 25.5% more power (p=0.005) than subjects receiving placebo. (Note: Again, simple dietary programs emphasizing protein and proper fats combined with resistance training can readily beat out those figures.)

    -- Total tissue percent fat decreased compared to placebo in a dose dependent fashion and achieved statistical significance at the 1 mg dose (p=0.02) and 3 mg dose (p=0.006) of ostarine. Total fat mass was lower in subjects receiving either the 3 mg or 1 mg ostarine dose, although not at a statistically significant level (p = 0.08 for both doses). For subjects receiving the 3 mg ostarine dose, total fat on average declined 0.6 kg compared to placebo. The site of fat loss differed among male and female subjects, with males losing fat primarily from the trunk and abdomen, and females losing fat primarily from the thighs and legs. (Note: That is a grand total of 1.32 lbs in a THREE MONTH time period... again, a good dietary regimen and exercise program - even at a moderate level - would beat the pants off of those figures)

    -- In this trial, ostarine had no apparent effect on bone mineral density, and bone turnover markers results were mixed.

    Yet my prediction is that with their slick sales campaigns, they will make a fortune out of selling this product - to an ultimately highly disappointed patient group.
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    Quote Originally Posted by TJack View Post
    Yet my prediction is that with their slick sales campaigns, they will make a fortune out of selling this product - to an ultimately highly disappointed patient group.


    There's another one that's in stage III trials. Don't remember the name.
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    Quote Originally Posted by RichTan View Post
    Injected testosterone has long term negative effects on future natural testosterone production. Do sarms have the same problem?
    Everybody who eats will die.
    Those who stop eating die sooner.

    Somebody who started using injected testosterone made decission to do it untill the end or real close to it.
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    Has Libido been studied?
    I believe it could be used in both men and women.
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    Quote Originally Posted by RichTan View Post
    Has Libido been studied?
    I believe it could be used in both men and women.
    This is a good point, regarding female administration. For some reason, this is something I have never considered with my female clients, although I have been on OSTA from SARMS SEARCH for a little over a week now, and LOVE it!

    I have not felt any suppressive properties regarding libido, but I am just now starting to note an upsurge in muscle fullness during the workout and a slight fat loss effect - it hasn't been that long yet.
  

  
 

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