Question about TRT with a 5 alpha reductase inhibitors
- 09-19-2007, 12:16 AM
Question about TRT with a 5 alpha reductase inhibitors
I am studying TRT. I have seen a number of places that men on 5 alpha reductase inhibitors should receive testosterone even if their level is high. Does anyone know what a reasonable starting dosage would be (assuming the patient wishes to continue taking it)? Would there be any reason to repeat the testosterone level? If so what would I do with it?
Is there a source that would have had the answer to this question or a standard TRT reference?
Thank you for your help
- 09-19-2007, 06:22 AM
- 09-19-2007, 10:26 AM
I am not an expert on this by any stretch of the imagination, but I have heard that men on 5 AR inhibitors should also be on aromatase inhibitors like arimidex, which should increase testosterone by blocking it's conversion to E2 and DHT.
I also understand it helps with the estrogenic side effects of finasteride, in some people.
09-19-2007, 10:51 AM
When one have high DHT but low FreeT he should make sure that his supplemental testosterone comes from shots rather than (DHT increasing) transdermals.
In my case I used Proscar and (at different time) Avodart while using Androgel.
My DHT was slightly below low range.
When I discontinued Avodart, my DHT went up to 3x over the top range (DHT=226).
Currently I am on Depo_T injection, waiting for blood test results.
Now, if I am average, my worry will be E2 rather than DHT.
09-19-2007, 05:06 PM
09-20-2007, 12:05 PM
Dr there are SOOOO many 5 alpha red inhibitors.
Which one's are you talking about in specific?
This seems like a feasable idea.
Best way to go about is to simply monitor DHT levels.
Remember many on proscar are perfectly fine and never have issues.
Remember Dr that 5 alpha drugs like proscar do NOT directly affect T levels - they lower DHT levels. When DHT levels are lowered to far, THATS when T levels suffer.
Dr I think you will be amazed at how mow most men's T levels are when you start running BW
09-20-2007, 09:58 PM
My DHT is naturally at the upper end of the range when not on finasteride. Still, keeping it at the low end of the range using trial and error finasteride doses made the difference in my hair, no question about it. I never suppressed my DHT levels to undetectable levels, just the lower end.
I've read that the 5 alpha enzyme affects other important biological processes that can lead to other issues, however.
So what can someone take besides finasteride? Saw Pametto, Nettle, etc?
09-21-2007, 08:25 AM
there has been some talk on these boards that pregnenolone and an AI can cause serum DHT levels to decrease.
09-21-2007, 04:48 PM
Don't believe all the stuff on the net.
There are tons of people who have used 5 alpha blockers successfully walking around that have never even turned a computer on, or even know about the side effects. Drugs like proscar also have alot of good for them not just for hair - they keep the prostate from swelling as well.
As far as other biological processes being affected, Im not really sure. But from an anabolic standpoint, they do lower DHT. Thats why I fell that everyone shiould simply monitor DHT levels and make sure they stay mid range.
09-24-2007, 04:22 PM
Be that as it may, from what I understand and have read, 5 alpha inhibitors also inhibit the formation of alloprenanolone, which is a neurosteroid of some sort.
09-24-2007, 04:51 PM
09-24-2007, 05:25 PM
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i use finasteride,avodart with test and armidex to block estrogen and have to say both an antiaromatase and a 5-alpha blocker used together keeps side very low even on high doses of test!!!
The LORD is my rock, my fortress, and my savior; my God is my rock, in whom I find protection. He is my shield, the power that saves me, and my place of safety.-Psalm 18:2
09-24-2007, 05:37 PM
09-24-2007, 09:37 PM
Zinc inhibits the enzyme that converts testosterone to DHT, so zinc deficiency increases DHT levels. Selenium protects the prostate from damage, while essential fatty acids decrease inflammation and swelling of the prostate
check youtr alkalline phosphotase when mine is low less then 65 my dht levels have always been high when my alkaline phosphotase was 80 my dht levels where in check.. kind of intresting that alkline phospotase is a magneium and zinc driven enzyme. High oestrogen tend to lower it due to lack of zinc ..
09-24-2007, 11:20 PM
09-25-2007, 02:33 AM
09-25-2007, 08:38 AM
TEST, TOTAL.....342.....(400 - 1080 ng/dL) LOW
DHT.....565.6.....(155 - 553 pg/mL) HIGH
ALK PHOS 41 (45 - 129 U/L) L
Since these labs I have started on 1% Androgel, 5 ml a day AND I have also started taking ZMA at night.
What do you think?
09-25-2007, 09:01 AM
09-25-2007, 09:33 AM
09-25-2007, 10:22 AM
However all androgenic hormones tend to work in balance. When any specific one crashes the others follow, like a delicate glass house.
Take E for example. Now E never converts back into T right? But why does T suffer when E is driven into the ground?
Same thing with DHT. Let us also not forget that DHT is 10 times more androgenic than T. Bottomed out DHT levels lead to depression, lethargy, weight gain, all which further hack away at precious T. So it may be also an issue of that as well.
09-25-2007, 10:55 AM
09-25-2007, 11:05 AM
I also get about 30 mg zinc in my multi, although there is a small amount of calcium in my multi.
That said, why do they put calcium in multis at all? I thought calcium was a large molecule and blocked absorption of a lot of stuff.
09-25-2007, 12:20 PM
09-25-2007, 03:13 PM
09-25-2007, 06:53 PM
Note the ingredients for the minerals, alot of them end in "ate".......In the mineral world, the "ates" are the good stuff.
Plus, you get a ton of benefits from being a member of LEF. They recently had a end of fiscal year discount sale - and where selling all sorts of stuff at HUGE discounts.
I picked up their Mega fish Oil caps, 120 in a bottle, for 6 bucks a bottle. Im like "I will take 20 Please"
09-25-2007, 11:24 PM
Cept for when you take out DHT - its an E antagonist, so E gets out of control which sends T down hill. But this only seems to happen when you quit the drug. Then also most of the time, DHT levels seem to return to normal so who knows what happens. I would say that its somthing to do with us still not converting to DHT properly....even though it appears we are on blood tests. Peyronnies disease, zero libido in the face of otherwise normal bloodwork.....somthing fishy is going on with the DHT. And why doesnt T and HCG work?......its gotta be DHT.
I totally agree that bottomed out DHT could give you all those symptoms...no doubt about it. I would go so far as to say that T takes a lot of the credit for DHT.
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