galapagos
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Jumpstarting HPTA using combo SERM + Avodart/SARM
As I understand it, the mechanism of HPTA shutdown is as follows...
Androgens/estrogens from an exogenous source increase in the hypothalamus, which responds by increasing expression of androgen/estrogen receptors.
Even when the exogenous source of androgens/estrogens is removed, this increased level androgen/estrogen receptors continues to produce significant negative feedback (as it amplifies even low levels of stimulation), such that GnRH, LH, and ultimately testosterone are never produced in abundance.
SERMS work by acting as 'partial agonists' at hypothalamus (as well as pituitary) estrogen receptors, thereby causing the hypothalamus to sense a lower level of estrogens, and in turn downregulate estrogen receptors. Less estrogen receptors means less negative feedback, and so testosterone levels increase.
We can perhaps imagine that a 'SARM' might one day be available, which could act in a similar partially agonistic fashion in order to likewise decrease hypothalamic AR.
This would in effect solve the other half of the puzzle, leading the way to a much higher success rate in restoring the HPTA.
Any thoughts?
As I understand it, the mechanism of HPTA shutdown is as follows...
Androgens/estrogens from an exogenous source increase in the hypothalamus, which responds by increasing expression of androgen/estrogen receptors.
Even when the exogenous source of androgens/estrogens is removed, this increased level androgen/estrogen receptors continues to produce significant negative feedback (as it amplifies even low levels of stimulation), such that GnRH, LH, and ultimately testosterone are never produced in abundance.
SERMS work by acting as 'partial agonists' at hypothalamus (as well as pituitary) estrogen receptors, thereby causing the hypothalamus to sense a lower level of estrogens, and in turn downregulate estrogen receptors. Less estrogen receptors means less negative feedback, and so testosterone levels increase.
We can perhaps imagine that a 'SARM' might one day be available, which could act in a similar partially agonistic fashion in order to likewise decrease hypothalamic AR.
This would in effect solve the other half of the puzzle, leading the way to a much higher success rate in restoring the HPTA.
Any thoughts?