- 08-17-2007, 02:14 PM
I don't understand for what pupose everyone is using this for. Is it for DHT control? Is it for adrenal fatigue? I understand the adrenal fatigue reason, but how does it control DHT? I was reading that it converts to progesterone in females but in males it converts to DHEA and that can convert to testosterone which could convert to DHT. Can someone please clear this up for me?
- 08-17-2007, 02:43 PM
FWIW, my doc says he uses it because it "backfills" pathways that can be interrupted by TRT.
- 08-17-2007, 03:31 PM
08-17-2007, 04:21 PM
I thought HCG would raise pregnenelone levels.
griffinannie you sound like you have 1st hand experience with it, how is pregnenelone cream??
08-17-2007, 04:29 PM
Pregnenolone is now added in most cutting edge HRT programs like Dr John uses. Pregenelone causes a small rise in progesterone, which helps prevent T to DHT conversion, so with the addition of preg, DHT is kept in check. Pregenelone also fills in metabolic pathways and causes a rise in not just T, but an increase in other androgenic hormones such as the various andros, DHEA and others. Very ingenious.
08-17-2007, 04:32 PM
I have read a recent study which linked the hormone responsable for female libido to be DHEA instead of testosterone(or atleast played a role in it along with testosterone), I am suspecting DHEA may play a role in male libido aswell in that case. I asked before but didnt get an answer, has anyone experienced or NOT experienced an increase in libido from pregnenelone or DHEA cream??
08-17-2007, 04:35 PM
08-17-2007, 05:15 PM
However this study has shown low testosterone bears no relationship to low libido in women under 45 years of age.
"We found a strong relationship between the low scores for desire, arousal and responsiveness and low DHEAS levels in women under 45, " said Professor Davis.
08-18-2007, 05:32 AM
I have been taking ResetAD that has Pregnenolone in it and I have been experiencing a rise in libido. I want to keep using it but I don't want to lower DHT because I usually have low leveles of it. I aslo don't want to give false indication on my next blood test.
08-18-2007, 05:33 AM
08-18-2007, 09:01 AM
I dont think oral pregnenelone is bioavailable, I have heard DHEA isnt so I would imagine pregnenelone isnt aswell.
08-18-2007, 11:06 AM
08-18-2007, 11:23 AM
Well in my case I can't take Pregnenolone I do 70mgs. of Depo T shots every 3 days and the 2 days in between each I do 350 IU's of HCG. Adding Pregnenolone makes me feel very hot and I sweat a lot. My understanding of this is that my HCG has my Pregnenolone up and adding more it goes right into E2. You can't get a good test on Pregnenolone but checking progesterone dose tell the story. My levels are upper mid range for progesterone.
08-18-2007, 12:16 PM
Pregnenolone and DHEA are both bioavailable orally, just less efficient than topical.
08-18-2007, 12:43 PM
08-18-2007, 12:44 PM
Progesterone=1.4 ng/dL(0.3-1.2)Milers book, page 242(1.5-2.5)
Pregnenolone=23 ng/dL(10–200) LE’s Optimal Range(100–170)ng/dL
So I believe one number but not the other.
Any studies that discuss accuracy of tests, specially these two (in this case).
There were statements like this about other items,
FreeT (for this I have discussion and some reference)
08-18-2007, 12:52 PM
08-18-2007, 01:10 PM
But in regard to FreeT
the problem is in specifying and actually getting the Freet test that you want.
They have at least two tests to figure out FreeT.
One is actual test
the other is calculation from TotalT and SHBG
you want calculation.
Before I got the order for blood test that I asked for, I went thu two other forms that Quest (and Lab Corp) insist on using.
It is hard to get specific test when wishing for particular test.
For my comming september test I will ask doctor to not use forms but write the request long hand.
I did that once with LabCorp, for short test, it went thru without them complaining.
08-18-2007, 03:46 PM
08-18-2007, 06:34 PM
Dr Miller and LEF is about the same view.
Can you post some references on high progesterone corelating with ED?
On page 94 of his book, dr Miller is saying:
"From my clinical experience, however, I have found that men with higher progesterone levels are healtier and more youthfull. My target for men is between 1500 and 2500 pg/mL, although I frequently see even higher levels in patients who are using anti-aging therapies. I rarely observe problems due to high progesterone."
Lets look at this chart, page #2
It is for women, but other than levels it apply
reports from Great Smokies are quite informative, easy to interpret.
08-18-2007, 07:33 PM
08-18-2007, 08:00 PM
Progesterone interferes with prolactin action at the alveolar cell's prolactin receptor level. While estrogen and progesterone are required to get full activity of the prolactin receptor,progesterone antagonizes the positive action of prolactin on its receptor by (1) inhibiting up regulation of the prolactin receptor, (2) reducing estrogen binding (lactogenic activity), and (3)competing for binding at the glucocorticoid receptor.
08-18-2007, 08:29 PM
08-18-2007, 08:33 PM
08-18-2007, 09:35 PM
ITSHECTIC, sorry for the delayed response, I've been out of town. To answer your question, my doc prefers oral to transdermal. The only reason I know is think he believes the oral is more bioavaiable to receptors in the brain. ( I hope I said that right.) I have tried both and can't say that I can tell a difference and since my doc knows a hell of a lot more than me I'm going with him. He seems to be rite on everything else.
08-19-2007, 12:11 AM
08-19-2007, 11:28 AM
08-19-2007, 11:49 AM
Please post what you have.
Any rebuttals from Quest or LabCorp would also help.
While you are at it (if you have the evidence)
provide supporting evidence to few other tests that their accuracy have been questioned lately.
08-19-2007, 05:24 PM
Thanks for the help everyone. I am going to try to get a script for pregnenolone, which isn't going to be easy considering my endo won't even give me HCG.
08-20-2007, 11:04 PM
What doses are you all using for Pregnenolone and DHEA?
Both of these hormones were below the lower end of the range on my blood tests, and I was told to take 25mg each, but after a few days I start feeling anxious and had trouble sleeping. Stopping and restarting on a couple of occasions produced the same effect, and I am not one that imagines side effects that aren't there. An internet search revealed these effects were likely due to the Pregnenolone.
Basically all I found on the net was either information that recommended higher doses (up to 200mg daily) or quite low doses (5mg or less daily or even every so many days). I can't seem to find any definitive answer on the subject.
If my levels are low, I would think I'd experience nothing but pleasant results from the replacement therapy. So is my starting dose too high?
08-21-2007, 01:24 AM
My guess is that it's the DHEA that does it. DHEA gives me anxiety and I know other guys have reported the same. I get anxiety on 25mg/day of DHEA and no anxiety at all from 200mg/day of Pregnenolone.
You can try one at a time to narrow it down.
08-21-2007, 11:03 AM
If I take a conservative dose of DHEA, like 25-50 mg., I don't feel a thing, although it keeps my blood level within range. If I take a high dose - 100 mg., I notice a definite brightening of my mood, and increased energy. In spite of the nice boost the high dose gives me, I limit it to 50 mg./day.
I have tried taking pregnenolone in doses as low as 2.5 mg. Even at that low a dose, it makes me anxious and interferes with sleep, so I don't take it at all. I would like to be able to take it though, because I have tested way below range for progesterone. I have a visit with my doc scheduled and am going to ask about a TD formulation.
08-21-2007, 11:10 AM
cpeil2: Perfect illustration of why this whole puzzle is so hard to figure out. We're completely opposite and might get the same advice from an untrained Dr.
08-21-2007, 11:21 AM
08-21-2007, 11:38 AM
08-21-2007, 11:41 AM
We want to shoot for 100mg of preg a day in cream, and 50mg of DHEA as well.
DHEA is best in cream, but capsule will do fine if no access.
Pregnenolone is horribly absorbed orally. DHEA is ok if good brand. Take DHEA with fatty foods like peanutbutter and your fish oils + Vit E. Take it twice a day.
08-21-2007, 11:44 AM
08-21-2007, 11:55 AM
08-21-2007, 01:54 PM
08-21-2007, 02:00 PM
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