[The Matrix]

betcha your t will be into the 1200 's next test because you are not injecting into your fat where it was just linkering there and aromatizing.

[jinxie]

Originally Posted by anyman

As some here may recall, I have proven resistant to TRT and eventually discovered that I appear to be a "hypermetabolizer", wherein I quite literally "piss out" most of the T I take in. Even higher doses such as 200mg/week of T cyp plus hcg 2x/week failed to get me much past 400 or so. And, I felt like I was only at 400.... Not good.

Dr. Shippen suggested I try a few drops of "cobalt" 2x/day as a way to reset my body's metabolism and allow the T to not get excreted so fast. Well, after a good 6 weeks or so I have mixed results, although all are arguably a step in the right direction.

Blood drawn on Wed, 4/2 showed T of 698--a new high for me of by a full 100 points. On the down side, Estradiol (E2) shot up to 64 (ouch...) It had previously been under 32, rose to 48 and now hit 64. That explains the resurgence in feeling tired and irritable. During this time I have been on 160mg of T cyp divided into 2 80mg doses/week and 2 hcg doses of about 325iu/week.

On a hunch, I tried a little test and tried DIM 2x/day for a few days and noticed an improvement.

Now, all I gotta do is see if Dr S will give me an AI so I can finally see the benefits of this long and torturous odyssey.

Anyman, you mean 2 times 325 IUs I assume, right?

As for an AI, there is liquidex. I took ADEX for 2 weeks at .25 mgs EOD, and it took me from 82 back to 20, where I was pre TRT. I felt awful at 82.

Hang in there, bro. It will come.

[anyman]

Originally Posted by jinxie

Anyman, you mean 2 times 325 IUs I assume, right?

As for an AI, there is liquidex. I took ADEX for 2 weeks at .25 mgs EOD, and it took me from 82 back to 20, where I was pre TRT. I felt awful at 82.

Hang in there, bro. It will come.

I am considering liquidex, but need to see what Dr Shippen says. He is oddly resistant to AIs for some reason, often preferring to lower the T dose first. I'd rather go the other way and get E down and THEN lower doses. Getting tired of feeling, well, tired.

Thanks for the kind words. Much appreciated.

[The Matrix]

Originally Posted by anyman

I am considering liquidex, but need to see what Dr Shippen says. He is oddly resistant to AIs for some reason, often preferring to lower the T dose first. I'd rather go the other way and get E down and THEN lower doses. Getting tired of feeling, well, tired.

Thanks for the kind words. Much appreciated.

When dealing with an issue as complex as yours one need to exmaine other avenues which I have previously mentioned to you before. Alot of your issues are more liver based then anything. You also need to be under a physcian care and not self expermenting with things.

[jinxie]

Originally Posted by anyman

I am considering liquidex, but need to see what Dr Shippen says. He is oddly resistant to AIs for some reason, often preferring to lower the T dose first. I'd rather go the other way and get E down and THEN lower doses. Getting tired of feeling, well, tired.

Thanks for the kind words. Much appreciated.

No worries.

You are taking 325 IUs of hCG, twice weekly, right?

[anyman]

Recent blood work has shown some improvements and need for more work. As I note above, T went to 698-- A new record for me by a full 100 points. To bad the estrogen also shot up as well to 64

But, after speaking with Dr S' office today he agreed to start me on a compounded version of arimidex. I am hoping for the best......

[The Matrix]

Originally Posted by anyman

Recent blood work has shown some improvements and need for more work. As I note above, T went to 698-- A new record for me by a full 100 points. To bad the estrogen also shot up as well to 64

But, after speaking with Dr S' office today he agreed to start me on a compounded version of arimidex. I am hoping for the best......

Lowering the e2 will increase total testoerone to 900 range. One clinet I had was 550 and e2 62 and put him on .25 EOD and total test went to 1000 and e2 to 32. My suggestion may be to give myomin 6 pills a day a try for 4 weeks then retest while swithcing to IM. Should help alot

[anyman]

To refresh, I am taking 160mg (2x 80mg) per week, with an arimidex sublingual pill prescribed by Dr S. Still doing 3 drops of "Cobalt" 2x/day.

T was 833- the highest by far I've ever seen. Estradiol (E2) dropped from the 60s to 52, which is still high, but better. Explains why I've had a bit more energy. I suspect E needs to drop even more and will be working towards this.

This is the best progress I've seen since I started keeping track. Energy is still so-so on some days, but on the whole the fatigue and brain fog are noticeably improved. Keeping my fingers crossed..... Curious to see what the next "tweak" is. I'll find out next week.

[JanSz]

Originally Posted by anyman

To refresh, I am taking 160mg (2x 80mg) per week, with an arimidex sublingual pill prescribed by Dr S. Still doing 3 drops of "Cobalt" 2x/day.

T was 833- the highest by far I've ever seen. Estradiol (E2) dropped from the 60s to 52, which is still high, but better. Explains why I've had a bit more energy. I suspect E needs to drop even more and will be working towards this.

This is the best progress I've seen since I started keeping track. Energy is still so-so on some days, but on the whole the fatigue and brain fog are noticeably improved. Keeping my fingers crossed..... Curious to see what the next "tweak" is. I'll find out next week.

How often are you taking Arimidex?
What is the total weekly dose, mg/week.


.

[anyman]

Originally Posted by JanSz

How often are you taking Arimidex?
What is the total weekly dose, mg/week.


.

I have .01mg "minitroche" custom mixed as a sublingual dose. It is taken with the T shot, which is presently 2x/week.

I would have preferred a "normal" dose and "normal" pill, but this is what Dr Shippen does.

[JanSz]

Originally Posted by anyman

I have .01mg "minitroche" custom mixed as a sublingual dose. It is taken with the T shot, which is presently 2x/week.

I would have preferred a "normal" dose and "normal" pill, but this is what Dr Shippen does.

One Arimidex pill =1mg

you are taking 1/100 of a pill twice weekly.

I would say 1/100 of pill is about as close to zero as one can get,
sublingual or not.
Possibly you have ment to say 1/10 (one tenth)
.................................................. .................................................. .........
"""Estradiol (E2) dropped from the 60s to 52,"""

This difference may be just random spread in testing.

You are doing now much better in TT area, but I do not have any warm feelings about your Arimidex situation, may want to discuss it with your doc.

What is your SHBG situation?

As you may have noted, JackBauer's got cut in half, be carefull.

http://**************.com/forum/show...9&postcount=10

[anyman]

Originally Posted by JanSz

One Arimidex pill =1mg

you are taking 1/100 of a pill twice weekly.

I would say 1/100 of pill is about as close to zero as one can get,
sublingual or not.

.
"""Estradiol (E2) dropped from the 60s to 52,"""

This difference may be just random spread in testing.

You are doing now much better in TT area, but I do not have any warm feelings about your Arimidex situation, may want to discuss it with your doc.

What is your SHBG situation?

As you may have noted, JackBauer's got cut in half, be carefull.

http://**************.com/forum/show...9&postcount=10

I wonder if sublingual allows for a lower dose. Still, Shippen is KNOWN for starting people at what to many are way too low amounts. He likes to work his way up at a pace best described as "Glacial". I can intellectually agree with this in theory, but as a guy just trying to feel normal it sure drags things out way too long.

Don't know about SHBG. It's always been low. Never above 12. I'll have to find out.

[JanSz]

Originally Posted by anyman

I wonder if sublingual allows for a lower dose. Still, Shippen is KNOWN for starting people at what to many are way too low amounts. He likes to work his way up at a pace best described as "Glacial". I can intellectually agree with this in theory, but as a guy just trying to feel normal it sure drags things out way too long.

Don't know about SHBG. It's always been low. Never above 12. I'll have to find out.

Your current
TT=833

SHBG=12

FreeT=283

You are about there.

Everytime you mention your low SHBG it think about you residing in NYState, you know what I mean.

[anyman]

The most recent blood work showed T at 833 (up from 698) and E2 at 52, down from 64. This happened by adding .1mg of Arimdex 2x/week to my usual routine of 160mg/week of T cyp divided into 2 80 mg doses and 325iu of hcg also 2x/week. Finally--a little more progress. Fatigue can still be an issue, but a bit less so.

For now, I am to double my Arimidex dose to .2mg twice weekly (quite a low dose according to him) and maintain the 160mg of T cyp (80mg 2x week) and roughly 325iu of hcg 2X/week. I am also to stay on the Iodoral, which the Dr. believes can take a good 6 months to clear things out, as he puts it. Topical Seligilene is lso to be continued as well. Cobalt, of course, will also be continued at 3 drops 2x/day.

Maybe I am making some progress--not only in feeling like my old self, but in finding the root cause. During the recent consult we discussed matters and the conversation turned to my apparent hypermetabolization issue.

While the Dr. was unsure as to why this may have happened, he did agree that my theory regarding this as the "root cause" may indeed have merit. It may be possible that once hypermetabolization took root my body burned off more T than I could make and in trying to keep up essentially "burned out". Whether this is permanent or reversible to some extent remains to be seen.

There is more to do and then some, but perhaps my story and results will help others.

[The Matrix]

Originally Posted by anyman

The most recent blood work showed T at 833 (up from 698) and E2 at 52, down from 64. This happened by adding .1mg of Arimdex 2x/week to my usual routine of 160mg/week of T cyp divided into 2 80 mg doses and 325iu of hcg also 2x/week. Finally--a little more progress. Fatigue can still be an issue, but a bit less so.

For now, I am to double my Arimidex dose to .2mg twice weekly (quite a low dose according to him) and maintain the 160mg of T cyp (80mg 2x week) and roughly 325iu of hcg 2X/week. I am also to stay on the Iodoral, which the Dr. believes can take a good 6 months to clear things out, as he puts it. Topical Seligilene is lso to be continued as well. Cobalt, of course, will also be continued at 3 drops 2x/day.

Maybe I am making some progress--not only in feeling like my old self, but in finding the root cause. During the recent consult we discussed matters and the conversation turned to my apparent hypermetabolization issue.

While the Dr. was unsure as to why this may have happened, he did agree that my theory regarding this as the "root cause" may indeed have merit. It may be possible that once hypermetabolization took root my body burned off more T than I could make and in trying to keep up essentially "burned out". Whether this is permanent or reversible to some extent remains to be seen.

There is more to do and then some, but perhaps my story and results will help others.

IF I were you I would divide that that 650 by 5 and break it down to smaller hcg shots. Some people have an issue of going over 125 ius at time causes an metabolic pathway to estrones or estrodial. I can not explain why, but I have seen it occur time and time in people that I have come across. You may want to speak to kanecore because he had this same issue and once he lowered the hcg from 250 ius to 125ius or lower then his symptoms got better mainly his fatigue. It may also help to reduce the amouint of armidex needed as well. Just a thought..

[jinxie]

Originally Posted by The Matrix

IF I were you I would divide that that 650 by 5 and break it down to smaller hcg shots. Some people have an issue of going over 125 ius at time causes an metabolic pathway to estrones or estrodial. I can not explain why, but I have seen it occur time and time in people that I have come across. You may want to speak to kanecore because he had this same issue and once he lowered the hcg from 250 ius to 125ius or lower then his symptoms got better mainly his fatigue. It may also help to reduce the amouint of armidex needed as well. Just a thought..

Anyman, I dont know how that small amount of Adex is getting it done. My E2 climbed to 82, and I got it down to 20 in a few weeks taking .25 mg EOD. I would think you could take safely .7 mgs per week, without risk of dropping it too low, and I think that this may optimize your T levels. .4 mgs per week still sounds too light to me. But WTFDIK?

Glad things are improving.