What is considered high levels of prolactin?
- 07-23-2007, 09:34 PM
What is considered high levels of prolactin?
I've seen a lot of comments about prolactin and am confused. My test scores were:
Prolactin 13.9 (2.0-18.0)
Some posters say prolactin should be around 3.0, whereas others say that it only is to test for prolactinemia, where it would be in the 90s. What's the story?
- 07-23-2007, 09:35 PM
- 07-23-2007, 09:38 PM
07-24-2007, 12:07 PM
Progesterone and prolactin are particularly nasty hormones, in that they cause — much more than estrogen — storage of body fat and mental depression. Prolactin can even cause lactation in men. And, by lowering progesterone and prolactin — just like lowering estrogen — you'll increase Testosterone through various feedback mechanisms.
Prolactin needs to be in the 5's or lower.
07-24-2007, 01:07 PM
I did some research on prolactin, as mine last time i checked was almost twice the upper limit.
In males testosterone can lower prolactin, and in women excess estrogen can raise prolactin, I would assume excess estrogen in males can raise prolactin. Wether this is true or not I am not quiet sure as Dr. John hasnt mentioned anything about it being linked to T and E.
07-25-2007, 04:29 AM
In all seriousness though, I understand that being hypogonadal can raises PRL..? In other words, adding in the missing testosterone can/should lower PRL... Is this correct? I think I am finally getting some hard..4-5mm lumps under/next to the nipple yet my prolactin is 8-9 and e2 is at 23...
I am seeing an anti-aging doc tomorrow, finally, so hopefully he leaves a good impression on me and is more willing to treat the symptoms I have. Then I get to fly out to my aunt's memorial in KC the next day.
07-25-2007, 04:32 AM
07-25-2007, 10:04 AM
We often face situation where laboratory ranges are questioned.
In regard to Prolactin I do not have anything better than LEF position stated here:
June 1999 Le Magazine: In The News: Elevated Prolactin Linked To Breast Cancer
Prolactin can be elevated in hypothyroidism when TSH is high. Some studies indicate that elevated prolactin may promote breast and prostate cancer growth.
We hear that Dr Shippen likes it at 3
What is your position on Prolactin, Dr John?
LEF position supports prolactin no higher than 2.
If you question their position, please have them change it, you are on their board.
Quote from above link:
Evidently, prolactin levels have a very wide range that conventional doctors would consider "normal." The problem is that few doctors are aware of the dangers of elevated prolactin, and if their healthy patients are in the high "normal" range, they would do nothing to treat this condition. A "normal" range often means a person has a "normal" risk for contracting a disease. Since members of The Life Extension Foundation don't want to have "normal" risk factors, here are some guidelines for those to follow who care about optimal health:
- Non-pregnant - Prolactin level no higher than 7.3 ng/ml
- Postmenopausal - Prolactin level no higher than 5.0 ng/ml
Female - Breast Cancer Patient
- Prolactin level no higher than 1.8
Male - Prostate Cancer Patient
- Prolactin level no higher than 2.0
my prostate is enlarged
07-25-2007, 10:38 AM
My take home, about ranges, if we do not know better we use them.
While making effort at narrowing range we use upper or lower 1/3 or 1/4 laboratory range.
My best guess at the monmet would be that Prolactin would fall in lower 1/4.
range (2-18) would then become (2-6)
Incidentally if you still follow this thread;
We have some problems when testing Estradiol at Quest.
They have two ulra-sensitives (RIA)(old) and (LC/MS/MS)(new)
Hardasnails had it tested twice
Estradiol, Ultra-sensitive (LC/MS/MS)
it show almost no estradiol (<2) when range (<29)
it show his estradiol over the range
Any experience with this ( new) tests.
Noted that only few Quest labs offer those new tests.
07-25-2007, 01:18 PM
i didnt meant to pass around non sense, i was just letting OP know of what i have researched people think too high is..
its good to hear doc J's POV ..
07-25-2007, 01:34 PM
I consider it is still in acceptable range.
I am just aware of it and watching it.
I took two bottles of Vitex, not sure if it made any difference,
I did not followed Vitex with blood testing.
07-25-2007, 01:39 PM
07-25-2007, 03:57 PM
when I look at mine those letters are absent.
I am in NJ and on my test report there is a part where they list all Quest laboratories that were involved in performing my tests, their three letter abreviations and complete name and address.
Each individual test, on right column have three letters indicating laboratory performing test.
If one goes to test menu
there is a pull-down window under REGIONAL LABORATORY
One have to choose laboratory location first an then the desired test.
Here each laboratory also have a three leter codes, unfortunately they do not match letters on the test report.
Put estrodial in search box and search on different laboratories, you come with different
07-25-2007, 10:16 PM
What is the half-life of PRL?
Obviously the levels will rise and fall, but how often does it stay at it's current level?
In other words... does it change greatly every hour or every minute or is it different day to day?
I have hypothyroidism and get small ammounts of white fluid coming out of both nipples.. I mentioned the TRH connection to my doc, and we rechecked the PRL #... both tests were under 10.. so I dunno wtf is going on unless it is spiking?
Also, I am only on 50mcg of synthroid, when we (doc and I) up my dose, will that help?
TSH obviously affects TRH but what else can change it?
07-25-2007, 10:37 PM
Prolactin (PRL): The release of prolactin is controlled by dopamine (Prolactin Release Inhibitory Hormone) produced by the hypothalamus. Prolactin is a polypeptide (small protein) of 198 amino acids (MW ~ 23,000), with 6 cysteines, 3 dissulfide bonds and a half-life (T1/2) of about 10 minutes.
07-25-2007, 11:14 PM
With a 10 minute half-life, how the hell can we rely on blood levels? Does it stay systematic longer?
What else directly affects dopamine besides testosterone, and PRL?
07-26-2007, 01:11 PM
Hypersecretion of prolactin can be caused by pituitary tumors, hypothalmic disease, breast or chest wall stimulation, hypothyroidism, renal failure, acute excercise, stress, eating, and several medications(eg; pheno-thiazines, metoclopramide). Hyper-prolactinemia inhibits gonadothropin secretion and can produce hypogonadism in men and women with accompanying low or inapropriedly "low normal" LH and FSH levels.
EndoManual_3rdEd_2004 page 311
Prolactin have no known role in male. page 205
07-26-2007, 01:23 PM
07-26-2007, 07:09 PM
My .02$ about prolactin -
Unless you have a tumor/prolactinemia, I wouldn't sweat it, because TRT + hcG + AI tends to fix it.
07-31-2007, 12:58 AM
well, b4 TRT i was 10.4....
my research tells me testosterone lowers PRL and GH can raise it??
if that the case, im 6 wks into my TRT and am now a 20, 2 over the limit?
07-31-2007, 09:16 AM
as long as Prolactin is within range it should be ignored and not manipulated.
If it is within range then: Prolactin have no known role in male. and that includes effects on sex.
This message is copied to my diary as my current view on Prolactin.
Thank you Dr John for your persistence thru many posts when holding your view on Prolactin.
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