First, do not panic.
Second, take home number:
Do not take more than 24 mg/kg/day
1 kilogram = 2.2046226 pounds
1 pound = 0.45359 kilogram
DIM---24 mg/kg/day
/-----------------------------------------------------------------------------

BodyWeght(lbs), (kg), (DIMdose(mg))
100 /// 45.4 /// 1089
105 /// 47.6 /// 1143
110 /// 49.9 /// 1197
115 /// 52.2 /// 1252
120 /// 54.4 /// 1306
125 /// 56.7 /// 1361
130 /// 59.0 /// 1415
135 /// 61.2 /// 1470
140 /// 63.5 /// 1524
145 /// 65.8 /// 1579
150 /// 68.0 /// 1633
155 /// 70.3 /// 1687
160 /// 72.6 /// 1742 my weight
165 /// 74.8 /// 1796
170 /// 77.1 /// 1851
175 /// 79.4 /// 1905
180 /// 81.6 /// 1960
185 /// 83.9 /// 2014
190 /// 86.2 /// 2068
195 /// 88.5 /// 2123
200 /// 90.7 /// 2177
205 /// 93.0 /// 2232
210 /// 95.3 /// 2286
215 /// 97.5 /// 2341
220 /// 99.8 /// 2395
225 /// 102.1 /// 2449
230 /// 104.3 /// 2504
235 /// 106.6 /// 2558
240 /// 108.9 /// 2613
245 /// 111.1 /// 2667
250 /// 113.4 /// 2722

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Thanks to Chip Douglas post on Meso board
Anabolic Steroids and Bodybuilding - View Single Post - Who has lowered E2 naturally in here ?
and reference
Linus Pauling Institute at Oregon State University


Quote:
Our next step was to take a more global approach by using microarray analysis to examine the expression of several thousand genes in the liver simultaneously after exposure to I3C rather than looking at only a few protein markers. We analyzed gene expression in trout livers after dietary exposure to I3C and DIM (24 and 78 mg/kg/day) and compared the gene expression profile to those of two known liver tumor promoters, 17β-estradiol (endogenous estrogen hormone) and β-naphthoflavone (a known inducer of CYP1A). We found that both I3C and DIM have very similar gene profiles to estradiol, suggesting that they act like estrogens in trout liver and likely promote liver cancer by this mechanism. Interestingly, DIM was a stronger estrogen than I3C. This data led us to question whether DIM would also promote liver cancer in trout similar to estradiol and I3C. Only a few studies have examined the effects of DIM on cancer development in animals, and none have examined the potential for DIM to promote cancer.

We performed a tumor study in trout to examine the effects of DIM on cancer development compared to 17β-estradiol. Feeding the trout either DIM (24 mg/kg/day) or estradiol in the diet long-term following acute exposure to a liver carcinogen resulted in more tumors compared to control animals. Concentrations of DIM lower than 24 mg/kg/day did not significantly increase the number of tumors. We confirmed that DIM was promoting cancer by acting like an estrogen by comparing gene expression in the liver samples over the course of cancer development. At all timepoints examined, gene expression in liver samples from DIM and estradiol-treated animals were very similar, indicating they are working by the same mechanism.