High progesterone, what does it mean?
- 05-05-2007, 03:49 PM
High progesterone, what does it mean?
My latest labs showed:
Estradiol, High-Sensitivity pg/mL 14
Progesterone ng/mL 2
Prolactin ng/mL 4.1
Estrone, Serum pg/mL 79
Estriol, Serum ng/mL 0.3
My progesterone and estrone are high. I wonder if that's why my blood pressure is higher than normal - water retention? I also don't really understand the magnitude of "high". Given a desired ranged of 0.3-1.2 for progesterone, 2.0 seems very high, but I don't know how to really read it.
Any suggestions on getting those numbers down?
- 05-05-2007, 04:13 PM
05-05-2007, 05:23 PM
05-05-2007, 05:35 PM
What is the range?
31 seems pretty low though. My DHT is about the same and my progesterone is also high. What is your Total Testosterone at?
My Testosterone gel I just started on should also up my DHT, which I'm thinking will naturally cause my Progesterone to lower. Are you on or going to be on TRT? Injection likely wont raise DHT as much as T gel will, so you could always try some DHT cream.
There is very little info out there on high progesterone in men. It seems to cause low sex drive and shriveled penis though...
05-05-2007, 05:46 PM
Testosterone, Total ng/dL 700 900 453
Testosterone, Free pg/mL 130 190 70.2
Testosterone, %Free 1 2.7 1.55
Dihydrotestosterone ng/dL 25 75 31
So raising DHT may lower progesterone? They compete for the same receptor, or something like that?
Also, I'm not having sexual sides of which I'm aware.
05-06-2007, 11:14 AM
Check adrenals be next suspcion
05-06-2007, 01:34 PM
lowered to 60 and 33 respectively (april13/07).
I think it is because of my increased doses of 6pills of (Dual-Action)+2pills of TMG.
Tmg (Trimethylglycine), 500 Mg 180 Tablets
Dual-Action Cruciferous Vegetable Extract With Resveratrol & Cat's Claw, 60 Vegetarian Capsules
My Estradiol (E2) did not changed at all, so no worry that DIM reduces it, it just manages the bads and favors the goods.
The Life Extension Revolution (Paperback)
by Phillip Lee Miller, M.D. with Monica Reinagel
Item Catalog Number: 33696
The Life Extension Revolution (Paperback), By Phillip Lee Miller, M.D. With Monica Reinagel
Progesterone p95 p242--Optimal Range(1500-2500)pg/mL men
So you are within range with progesterone.
What is your pregnenolone level.
Mine was in low range. I was eating pregnenolone pills, no action.
When I switched to prescription 100mg/1gram, 1gram/day cream I got action.
Among other things my DHEA got above range first time in years.
05-06-2007, 02:21 PM
05-06-2007, 02:37 PM
OK, so given that range my progesterone is OK; mine being 2000pg/mL. The range I specified came with the test results.
Pregnonolone wasn't part of the the test.
MY DHEA is low with the given range:
DHEA Sulfate mcg/dL 350 500 238
Now 238, last December was 90. I currently take 1 50mg DHEA pill every morning. I'll start taking 2 qd, one morning, one late evening.
Thanks for the help everyone. I think I'm within range on the thing I was most worried about - progresterone.
05-06-2007, 07:06 PM
And pregnenolone by taking pregnenolone pills.
If you are like me, do pregnenolone test first. If you low in pregnenolone and DHEA take just pregnenolone cream.
If you good at pregnenolone and low at DHEA take DHEA cream. I am talking prescription strenght not the s**** stuff over the counter.
05-06-2007, 07:40 PM
05-06-2007, 09:09 PM
05-07-2007, 10:35 AM
05-07-2007, 10:39 AM
I was not able to get anywhere with my DHEA taking DHEA pills.
Other than pregnenolone cream (script reqd)
There are pregnenolone creams over the counter I suspect they are not worth the time, money and frustration.
There is DHEA cream, not sure if need script or not.
05-12-2007, 04:34 PM
05-12-2007, 05:06 PM
05-13-2007, 04:02 AM
05-13-2007, 01:18 PM
05-23-2007, 06:04 PM
05-23-2007, 10:04 PM
I was a DHEA non-responder. I got a bulk jar [75 grams] of DHEA power and was taking 1/8 teaspoon and DHEA went up past 600.
05-24-2007, 10:35 AM
05-24-2007, 09:37 PM
I found a post where Dr MArciano says that Progesterone can be released by stress, and that DHEA can be as well (obviously also Cortisol.
I have high DHEA and Progesterone, I wonder if this has anything to do with stress?
05-24-2007, 11:35 PM
05-25-2007, 09:52 AM
Then answer me this how come my tits hurt and i have BPH with normal estodial levels?
Things that can be causing
1.Dhea and hcg elevated esterones system is bottle necking where (ned to futher examine)
2. severe undermetylation (homocysteine of 3.9 tells me that and anything under 5 is a possible indicator) possible elevated 4,16 hydroxy not being properly disposed and were the bottle neck could be occuring (urine test would indicate this)
3. too much DIM causing depeltion of methl groups resulting in lowering of gluthione which is already indicated on lab tests.
4. hidden iodine defieincy due to dietary habits for past 25 plus years (elevated esterone and low estriol would idenitfy this on urine test.)
Drop in methylation went from 7.5 to 4.0 after one month of TRT 2 years ago could there have possible been a shift in no e2 but esterone metabolism which was the underlying cause.
Severe iodine defeincy caused a metabolic shift casuing esterone to elevated and conversion of e1 to e3 (protective estrogen) to be reduced. e3 is protective for the prostrate and also breast tissues. I have always had senisitive nipples even though e2 has been in constant check it has never been above 20 the whole 3 years making me think that elevated esterone was the culprit the whole time and no dr even freaken checked for it.. Further research indicated that breast and prostrate tissue have receptors for esterone as well which could possible mean that if esterone can bind to e2 receptors why could it also bind to oones in hypothalamus or pituitary or ever else in the body. This could possible cause both an e2 defieincy and estrodial excess at the same time. The un used e2 would put undue stress on the liver. Also esterone is an estrogen how the hell can liver distguish between e1, e2? So is it possible that my elevated shbg could be a result of the un used e2 or esterone causing the liver to produce more shbg. Shbg increases with estrogen correct by it does not know what kind (e1,e2,e3).
05-25-2007, 05:01 PM
I like the idea that the esterone could be hitting E2 receptors in the breast and prostate, as well as hitting the HPTA. I don't know what a trial of a SERM might indicate by how you feel. I have no idea if a SERM impacts the prostate or not. After a few weeks your urine flow might suggest whats going on. As a limited trial, you might learn something interesting even with a SERM being unsuitable as a longer term thing.
05-26-2007, 12:12 AM
I like alot of what your saying.
But let us not forget some underlying issues.
Estrone(E1) comes from 4 andro. E2 comes from E1 BUT ALSO testosterone. Remember that both Deca and Sus are known to have low testosterone converting to E2 (this is helpfull when injecting huige amounts in anabolic steroids users BTW), but not so much of a good idea for people on HRT as their SOLE and ONLY intake of Testosterone.
So someone like your friend who is using Deca + AI would have an E2 level in the crapper. Who knows also what the long term effects of using Sus + Deca are as sole intake of anabolic action within the body on estradoil - with all the T being produced exogenously and having little T - E conversion, PLUS the added AI action(and throw DIM in to boot) we could very well see a situation were someone becomes E1 dominant and E2 depressed.
05-26-2007, 12:48 PM
05-26-2007, 01:38 PM
I would like to see your buddy frontload that stable ester, preferably CYP(cheaper) with an initial 200mg dose of T to get things going and get E2 up and rolling. Give that 5 or 6 days then
After then we can go with an EOD or E3D protocol with T + hCG.
Make sure we are getting plenty of Flax to help support E2 functioning. Once E gets rechecked in 4-6 weeks, then go from there.
05-26-2007, 04:38 PM
05-27-2007, 01:57 PM
Another link showing favorable estradoil levels helps with insulin sensitivity - http://ajpregu.physiology.org/cgi/co...ll/289/4/R1064
This link also shows that progesterone and insulin sensitivity is still a gray area.
I am further amazed at estrogen and how important it is to the body(second link) once you study it. Its a shame how bad of a rap estrogen gets nowadays. This mostly comes from the fact that E2 needs to be kept in a very close sweet spot (I am near certain that number is 20 - 29). Unlike E, with T there is a huge playing field to swing for (500 - 900).
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