E2 and E16 confusion.

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    E2 and E16 confusion.


    In this forum i see a lot of guys concerned with their E2 levels. however i have seen a few studies that say E2 is the "good" E and 16E is the "bad" E. In these studies they actually say that Dim helps convert E16 into E2. I am just a little confused. Why is everyone so enfatuated with E2 if E16 is the "bad" E.

    its here in this study

    All About Diindolylmethane

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    Quote Originally Posted by Dr. John View Post
    There are three main groups of the 40 or so estrogens. Estrone (E1), Estradiol (E2) and Estriol (E3). Estradiol and Estrone convert back and forth. Androgens cause a preferential shift toward Estrone.

    Estrone then is metabolized into three pathways. 2-OHE (good), 4-OHE (very bad) and 16-alpha-OHE (bad).

    favors a shift toward good 2-OHE, and away from bad 16-OHE. It is not correct to say the 16-OHE is converted into 2-OHE.

    As I have seen a couple of studies where DIM also increased 4-OHE production, I advise to use TMG to wash the 4-OHE downstream to its better metabolites. It is a methyl donor, so also does many other good things for us.

    There it is, in a nutshell.
    Great Info Dr. John
    Do you recommend DIM?
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    Quote Originally Posted by Motomatt View Post
    Great Info Dr. John
    Do you recommend DIM?
    he has in quite a few other threads.
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    Quote Originally Posted by Dr. John View Post
    There are three main groups of the 40 or so estrogens. Estrone (E1), Estradiol (E2) and Estriol (E3). Estradiol and Estrone convert back and forth. Androgens cause a preferential shift toward Estrone.

    Estrone then is metabolized into three pathways. 2-OHE (good), 4-OHE (very bad) and 16-alpha-OHE (bad).

    DIM favors a shift toward good 2-OHE, and away from bad 16-OHE. It is not correct to say the 16-OHE is converted into 2-OHE.

    As I have seen a couple of studies where DIM also increased 4-OHE production, I advise to use TMG to wash the 4-OHE downstream to its better metabolites. It is a methyl donor, so also does many other good things for us.

    There it is, in a nutshell.
    thanks doc. appreciate the wisdom relayed in lamends terms.
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    Quote Originally Posted by Dr. John View Post
    There are three main groups of the 40 or so estrogens. Estrone (E1), Estradiol (E2) and Estriol (E3). Estradiol and Estrone convert back and forth. Androgens cause a preferential shift toward Estrone.

    Estrone then is metabolized into three pathways. 2-OHE (good), 4-OHE (very bad) and 16-alpha-OHE (bad).

    DIM favors a shift toward good 2-OHE, and away from bad 16-OHE. It is not correct to say the 16-OHE is converted into 2-OHE.

    As I have seen a couple of studies where DIM also increased 4-OHE production, I advise to use TMG to wash the 4-OHE downstream to its better metabolites. It is a methyl donor, so also does many other good things for us.

    There it is, in a nutshell.
    Why do we watch Estradiol(E2) and when is too high we take DIM which does nothing for E2?

    We should be watching Estrone if that is what we can adjust.
    Need some help here, please.
    =============
    My test Oct06
    estrone, serum--------------------78 pg/mL (12-72)
    Estradiol, sensitive----------------27 pg/mL (3-70)
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    Quote Originally Posted by dynomite View Post
    he has in quite a few other threads.
    Thank you.
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    Quote Originally Posted by JanSz View Post
    Why do we watch Estradiol(E2) and when is too high we take DIM which does nothing for E2?

    We should be watching Estrone if that is what we can adjust.
    Need some help here, please.
    =============
    My test Oct06
    estrone, serum--------------------78 pg/mL (12-72)
    Estradiol, sensitive----------------27 pg/mL (3-70)
    good question i would like to know the answer to that as well
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    Quote Originally Posted by dynomite View Post
    good question i would like to know the answer to that as well
    If you have a time, may want to bump that post.
    But do both, upper and lower part, so it will be easier to catch Dr's attention.
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    So when readin the info on TMG and it says it promotes "healthy" levels of homocysteine what does that mean? Does it lower, raise, convert etc?
  

  
 

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