Great Info Dr. JohnThere are three main groups of the 40 or so estrogens. Estrone (E1), Estradiol (E2) and Estriol (E3). Estradiol and Estrone convert back and forth. Androgens cause a preferential shift toward Estrone.
Estrone then is metabolized into three pathways. 2-OHE (good), 4-OHE (very bad) and 16-alpha-OHE (bad).
favors a shift toward good 2-OHE, and away from bad 16-OHE. It is not correct to say the 16-OHE is converted into 2-OHE.
As I have seen a couple of studies where DIM also increased 4-OHE production, I advise to use TMG to wash the 4-OHE downstream to its better metabolites. It is a methyl donor, so also does many other good things for us.
There it is, in a nutshell.
Do you recommend DIM?