New hypothesis: Adrenal insufficiency caused chronic fatigue
When hypomagnesia is present, or/and the ratio magnesium/calcium is low (lots of calcium, relatively low magnesium levels), the excess calcium levels will cause excess calcium influx into all living cells. This is because magnesium, can only act as a calcium-channel blocker if it is in the right balance with calcium. The calcium influx will cause nitric oxide (NO) synthesis inside the cells. The NO suppresses the adrenals, causing adrenal sufficiency. The low cortisol levels will further increase NO synthesis. This is because the low cortisol levels are making the immune system hyper. This means upregulated nitric oxide and other cytokines. The increased nitric oxide levels will further depress the adrenals. Vicious Cycle.
How does calcium influx cause NO synthesis
The calcium binds to calmodulin, which in turn activates different enzymes, including neuronal nitric oxide synthase (NOS). The NOS increases the formation of nitric oxide (NO).
How does NO cause glutathion depletion
NO, together with the superoxide anion, forms peroxynitrite, which in turn oxidizes the glutathione.
How do low cortisol levels cause low eryhtrocytes
Cortisol stimulates erythropoiesis (the building of new red blood cells). Low cortisol levels explain the borderline anemia commonly seen in CFS and FM, which is not iron anemia. It can only be detected by checking the HTC, because hemoglobin levels will look normal.
Summary
Eating lots of carbohydrates will cause excess magnesium excretion, which will result in a low magnesiun/calcium ratio
Not enough magnesium left to act as calcium channel blocker, result: Increased calcium influx
Calcium influx will cause excess NO production
High NO levels will suppress adrenal hormone production
Low adrenal hormone levels will further increase high NO, inducing a vicous cycle
Other ways to start the NO vicious cycle
Ofcourse, the magnesium deficiency is just one way to start the vicious cycle. Any condition that causes excess NO will be able to start the vicious cycle. Think of intestinal bacteria, a viral infection, zinc deficiency, low antioxidant status, elevated stress levels for prolonged times.
How does adrenal insufficiency cause low blood pressure, hyperkalemia and sodium deficiency ?
The adrenals produce cortisol, but also aldosterone, which regulates blood pressure, sodium and potassium balance.. Low levels of aldosterone will cause the hyperkalemia, the sodium deficiency and the low blood pressure.. Besides that NO is a potent vascodilator. Excess NO levels in the blood will cause low blood pressure.
How can L-lysine be of any help ?
L-arginine, an amino acid is the direct precursor of NO. Without L-arginine, no NO can be formed. Arginine uptake into neurons is controlled by non-NMDA glutamate receptors. This became evident when these receptors were blocked by argninine-uptake inhibitors such as L-lysine which functions as
antagonist of these glutamate receptors. Eating less arginine and increase the lysine intake will suppress the NO production.
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Save Your Brain - Part 2
