Another area you want to look into is the methylation cycle. Alot of bodybuilders i know have alterations with in these pathways. Once these pathways are balances (under or over methylated) then your antioxidents reserves will be functioning optimally protecting us from enviromental exposures and possibly even cancer. Most general population has to some degree a fatty liver and they may not know it now but years down the road it will start to show up. The methylation cycle imbalances can also be a way to correct thyroid, adrenal, testosterone problems but this is one area that drs are not aware of that even exists. By not having enough gluthione your can not store glycogen and there for your body goes into intracellular starvation with out you even knowing about it eventually shutting down your thyroid, adrenals,ect. Give you an example how this could posible lead into cancer from estrogen for example. Estrogen depletes zinc which is need for a reaction calle methionne synthase. This enzyme helps to convert folic acid to its active form and helps to recycle homocysteine back to methionne which then produces sam-e and cycles starts all over again. People that are undermethylated this process does not happen and either it causes homocystein to build up to high levels or it gets diverted by other pathways TMG//choline/ CBS. Now here comes the kicker and the most dangerous parts. if a person is under methylated for to long and the folate/b-12 /tmg pathway are depleted or (for people that do not eat whole eggs and have choline deficeincy). in order to keep the cycle in balance the body will then break down the cell membranes to get the choline from phosphodytl choline and basically the cell cause self suicide (atoposis) and as you can see this is not good at all. So mitochondrial rejuvenation is excellent, but do not forget about its twin sister which is even more important proper methylation. It tok me nearly 2 years to master ths biochemistry, but its also the only reason i am alive to day as well. Through study the mitochondrion and methylation pathways i am free of depression and just have to get my hormones in balance and be good to go. scarey part is that 50-60% of the population is in deep crap and only time untill medical profession waking up to see where disease comes from and thats within the cells and how they replicate. i had my mid life crisis 20 years early and would not have changed it for anything.