Which are your thoughts about transdermal delivery for DHEA?
Phil or dr john if some one is taking cortisol (isocort) could there chance that it could be lowering ones DHEA level. I know that these needs to be checked me lab test, but i will get my insurance in 2 more weeks finally I was just thinking hypothetically speaking for now since they are antagonistic.
I have been on DHEA 25mgs 2 x's a day and my levels have been good at about 400. I was on Isocort it is said to have 2.5 mgs. of cortisol in each pill I was doing 8 pills. I got my Dr. to switch me to Cortef 5 mgs 4 x's a day. On my next blood test in 4 weeks my Testosterone and DHEA went way up DHEA went over the top of the range. I had to cut back down to 25mgs a day. We are not changing my TRT dose until we do a new blood test to be sure the labs were good.Originally Posted by hardasnails1973
Thats interesting so this is basically saying isocort is very week compared to HC. So basically the isocort was not doing anything for you. Where your white blood cell counts also lower on the isocort as well ? i heard if you stay at 20 mgs HC you can use it long term with out side effects and that even normal people (non adrenal fatigue) can actuall get benefits as well from it. Study done 10 mgs was given to a person giving a speach vs palcebo and the person given the 10 mgs have less fear and anxiety ..mmm how interestingOriginally Posted by pmgamer18
Phil could it be possible that your estrogen domince/imbalance is putting added stress on your adrenals and that once you get your estrogen inbalance that your adrenals can heal eventually. Or do you think the adrenal caused the estrogen domiaince or may be you will just never know LOL. Also to intersting how i had low blood pressure all this time when not taking armidex with isocot, but when taking armidex with isocort it actuially normalized to 120/80. Estogen actually lowers blood pressure so too much estrogen can cause too low of blood pressure drop possibly?Originally Posted by pmgamer18
I have been charting my temps for 11 months did Isocort 8 pills = 20 mgs. of Cortisol a day. My temps starting out were way down going from 96.6 to 97.8 up and down and low. When I added Isocort the swing narrowed down to with in .6 tenths of a deg. So I started on Armour and my temps went up for about 2 weeks then back down so I added 15mgs. this went on for about every 2 weeks adding armour. Still my Temps were swinging up and down more then .2 tenths so I got my Dr. to give me Cortef I feel Isocort helped but it has other hormones in it that were not helping. Now on 5mgs 4 x's a day of cortef my temps look dam good.
Originally Posted by hardasnails1973
I don't know I just put up a new post "Estradiol and Feeling Hot" I do know high E2 caused a lot of problems for me that went away after I got it down. I never could get a good reading on my BP every time someone takes it it goes way up it's call White Coat Fever. I take it my self and I am 130/78 on avg. Still I can take it and get 180/120 would sit for 30 min.'s and do it again and it's good. It's dam hard to keep all of the hormones in check adding Cortef everything went up on my T levels and DHEA so it looks like when you find the one that is off and fix it the rest follow and do better.Originally Posted by hardasnails1973
Very true by treating the adrenal fatigue and estrogen imbalnace same time it all works togetherOriginally Posted by pmgamer18
If I don't supplement with 25mg/day of DHEA, wouldn't my natural DHEA come up on its own in a matter of time; since my LH is still firing at a good level??
is that because your on HCG which is stimulating it. Also too progrmmer your dhea began to rise in conjuction when your started the HCG which highly supports theory that hcg will increase DHEA and dhea levels will increase free testosterone and possible even lower estrogen
Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency.
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) age-related withdrawal is very likely to be involved in the aging process and the onset of age-related diseases, giving rise to the question of whether preventing or compensating the decline of these steroids may have endocrine and clinical benefits. The aim of the present trial was to evaluate the endocrine, neuroendocrine and clinical consequences of a long-term (1 year), low-dose (25 mg/day) replacement therapy in a group of aging men who presented the clinical characteristics of partial androgen deficiency (PADAM). Circulating DHEA, DHEAS, androstenedione, total testosterone and free testosterone, dihydrotestosterone (DHT), progesterone, 17-hydroxyprogesterone, allopregnanolone, estrone, estradiol, sex hormone binding globulin (SHBG), cortisol, follicle stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were evaluated monthly to assess the endocrine effects of the therapy, while beta-endorphin values were used as a marker of the neuroendocrine effects. A Kupperman questionnaire was performed to evaluate the subjective symptoms before and after treatment. The results showed a great modification of the endocrine profile; with the exception of cortisol levels, which remained unchanged, DHEA, DHEAS, androstenedione, total and free testosterone, DHT, progesterone, 17-hydroxyprogesterone, estrone, estradiol, GH, IGF-1 and beta-endorphin levels increased significantly with respect to baseline values, while FSH, LH and SHBG levels showed a significant decrease. The Kupperman score indicated a progressive improvement in mood, fatigue and joint pain. In conclusion, the present study demonstrates that 25 mg/day of DHEA is able to cause significant changes in the hormonal profile and clinical symptoms and can counteract the age-related decline of endocrine and neuroendocrine functions. Restoring DHEA levels to young adult values seems to benefit the age-related decline in physiological functions but, however promising, placebo-controlled trials are required to confirm these preliminary results.
PMID: 15672938 [PubMed - indexed for MEDLINE]
I guess the significant drop in LH and FSH means that 25mg/day of dhea over a long period of time is suppressive to HPTA.
Ultra Micronized - Micron 5 DHEA from McPherson Labs.
Anyone knows if that is any good? Just placed an order.
They say it has been used in clinical research as well and is slow release. Cheap as well- around 17-18$ (if that is considered cheap)
By the way, how long after starting dhea supplementation do ihave to worry about DHT rising levels and conversion of T to estrogens?
Im thinking of doing tests at 2-3 weeks time after starting- is that good enough?
Or is it a better choice to supplement with saw palmetto from the start ???? (since i have chronic prostatitis from finasteride)
What else to take to avoid liver and other problems while on dhea?