Low Pregnenolone?

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    Low Pregnenolone?


    I was going over blood labs this morning was going in for blood work and seen my Pregnenolone was low normal at the bottom of the range 21 range <20 to 150 ng/dl. Should I supplement this.
    This was posted by one of the guys at a different site.

    "Doing the TRT is going to lower your pregnenolone farther. All the adrenal hormones are converted from pregnenolone, including cortisol, DHEA and aldosterone among others. Supplementing pregnenolone will help you tremendously, and you can get it from any health food store. Buy the 5mg capsules and start at 10mg for a few days and note how you feel. Increase by 5 mg for every few days. Taking pregnenolone will increase progesterone, so you don't want to take too much. Hopefully you will not need more than 20-30mg. You will need to monitor progesterone as well."

    I am on TRT and have low cortisol levels taking Isocort = 20mgs of cortisol. I just started on Armour for Thyroid and take 50mgs of DHEA a day.
    Phil

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    Quote Originally Posted by Dr. John
    I quit running pregnenolone assays--they are ALWAYS low. Dr. Rothenberg made this same comment in one of his lectures.

    I use a trandermal cream whihc Signature compounds for us.

    I now want all of my guys on TRT to take it, along with DHEA, to help rebalance the pathways.

    Pregenenolone is lowered in TRT because the P450scc enzyme (which converts CHOL into pregnenolone) is reduced in activity by lowered gonadotropins, as it is by ACTH. This is also why I always use HCG in every TRT patient.
    I can buy these creams but doing Isocort for my low Cortisol levels it may not be needed.
    Phil
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    Quote Originally Posted by Dr. John
    I quit running pregnenolone assays--they are ALWAYS low. Dr. Rothenberg made this same comment in one of his lectures.

    I use a trandermal cream whihc Signature compounds for us.

    I now want all of my guys on TRT to take it, along with DHEA, to help rebalance the pathways.

    Pregenenolone is lowered in TRT because the P450scc enzyme (which converts CHOL into pregnenolone) is reduced in activity by lowered gonadotropins, as it is by ACTH. This is also why I always use HCG in every TRT patient.
    I have read where folks who are hypothyroid can have thicker skin that can lead to issues with absorbing meds transdermally. If that is true, one could hopefully improve the situation by increasing their Armour dosage. I am curious though as to what one might do in the mean time. Would taking Pregenenolone orally be a viable option? It is available, but I have no idea if the PharmacoKinetics would be the same as it would administered orally.

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