I have lowed my T does turns out going on Isocort = 20mgs. of cortisol my T levels went way up my body is not using up the T meds as fast as there were. So I had to lower my T dose was doing 62 mgs every 3 days and 400 IU's of HCG the 2 days in between. Now I am doing 41mg and the same on HCG so now I am doing .25 mgs of Arimidex every 5 days was doing .5 mgs. every 3 days.
Here is a cut and paste on what Dr. Marianco says about why some need a higher dose of T meds. A cut & paste.
You may find him posting here with Dr. John soon.
Re: what is the best time get blood test for testostorne levels?
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Quote:
Originally Posted by the/rock
I am on 250mg enthante a week .trt therapy.
On my second week so going for tests soon.
I was wanting to know when the best time to get
blood tests done for levels of test .I have looked on
the internet and what i have learnt is the test levels
peak at 24 to 48 hours after jab and are at there lowest
the day before next jab.I am going to ask the doctor if i can
test 48 hours after first test and on the morning of my jab.
(blood test are cheap in my counry).to get an adverage of
testostorne to see the difference and how much enthante
a week a will need to get me in a good range ,good energy
,increased libido,fat loss etc, with out side effects.I have a
great doctor!!
What do you think?
Obtaining a total testosterone Peak blood level and a Trough blood level is useful.
The Peak for Testosterone Enanthate is about 24-48 hours after the injection.
The Trough (lowest level) for Testosterone Enanthate is just before the next injection.
Obtaining both levels will give the range of testosterone one's body is exposed to.
This is helpful to see if a person is within a good therapeutic range.
The shorter the intervals between injections, the flatter the range will be.
Large variations between the peak and trough can be a problem because there can be large changes in DHT and Estradiol levels - contributing to problems such as weight gain, acne, hair loss, and hot flashes. Hot flashes occur when estradiol levels drop quickly - they are withdrawal from estrogen.
Large peaks of testosterone may also result in large amounts of DHT and Estradiol being made. When Estradiol is made from testosterone, its peak levels last much longer than testosterone itself - resulting in a larger exposure to estradiol even as the levels of testosterone drop.
Testosterone Enanthate usually has a half-life of about 7-9 days. This results in a good total testosterone level (e.g. 700-900) at a dose of 100 mg a week. The half-life varies though depending on the person's ability to metabolize testosterone enanthate and testosterone.
In some men, the half-life of Testosterone Enanthate is much shorter. For example, in some men, the half-life is around 4 days. To achieve a total testosterone of around 800, such a person would need about 200 mg a week.
Given a Testosterone Enanthate dose of 200 mg every 2 weeks for an average hypogonadal male, the total testosterone curve shows a peak of around 1250 ng/dl approximately 24-48 hours after the injection, 1000 ng/dl around 4 days after the injection, 800 ng/dl 7 days after the injection, 600 ng/dl 10 days after the injection, and baseline about 14 days after the injection.
A way to tell what the half-life would be is to give the person a 200 mg dose then measure the total testosterone approximately 4 days or 7 days later. If the level is significantly lower than the average male dose curve, then the half-life is going to be shorter.
For example, I have a patient with a level of about 600 ng/dl 4 days after the 200 mg injection. This is about 40% less than the expected 1000 ng/dl seen in an average person. He has a very short half-life for testosterone enanthate. One could argue that his half-life is about 3 days (since 600 ng/dl is about half of the peak of 1250 ng/dl 24 hours after the injection). His body quickly destroys testosterone. He needed a 200 mg a week dose to achieve a trough blood level of about 800 ng/dl. It was best to dose this 100 mg twice a week to maintain an even blood level, avoiding a roller coaster effect, given the very short half-life of testosterone and testosterone enanthate in his body.
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Any statement I make on this site is for educational purposes only and is subject to change. It does not constitute medical advice, does not substitute for proper medical evaluation from physician, does not create a doctor/patient relationship or liability. If you want medical advice, you will have to make an appointment. Thank you.
Phil
