Testosterone Supplementation Improves Spatial and Verbal Memory in Healthy Older Men, Cherrier MM, Asthana S, Plymate S, et al, Neurology, July 2001;57(1 of 2):80-88. (Address: Dr. Monique M. Cherrier, E-mail: firstname.lastname@example.org)
In 25 healthy male volunteers who were between 50 and 80 years of age, subjects completed a randomized, double-blind, placebo-controlled trial in which weekly intramuscular injections of either 100 mg of testosterone enanthate or saline placebo were given for 6 weeks. Circulating total testosterone levels increased an average of 130% from baseline at week 3 and 116% at week 6 in the treatment group. Due to the aromatization of testosterone, estradiol increased an average of 77% at week 3 and 73% at week 6 in the treatment group. There was significant improvement in cognition seen for spatial memory, spatial ability and verbal memory in older men treated with testosterone compared with baseline and the placebo group.