Pregnolone and DHEA
- 01-24-2014, 03:36 PM
Pregnolone and DHEA
It's weird that I have been hearing and reading so much about this lately because I had to call my endo today to update insurance info and he quickly ran through my charts on the phone. He asked if we had ever discussed adding this in and I said no, that we found a good protocol with my test cyp injects and I felt really good. He tells me that I am mid range and that he think I could feel even better if I were in the top range for DHEA and now wants me to take sublingual DHEA 25mg 2xd and 50mg of pregnolone and then run labs in a month.
I just picked the stuff up that he recommended, so I guess we'll be seeing how this works out.
- 01-24-2014, 03:52 PM
- 01-24-2014, 04:03 PM
I actually bought oral DHEA because he told me that regardless of the few studies stating otherwise, that it is very effective and almost all his patients use it. The pregnenolone is sublingual per his recommendation. I am up in my office and don't have the packaging so I do not know the brand names, but can post that up later.
01-24-2014, 04:05 PM
01-24-2014, 04:22 PM
Ok, I called my wife to look at the bottle. The brand is Superior Source. I will say that it does not dissolve instantly like it says, but keeping it under your tongue for 30-45 sec and it gets soft enough to crush with your tongue. I can't say if this is a good brand as I have only tried the one dose, but I will say that I have been hyper since taking it. Not really physically hyper, but mentally I am very aware. I have no idea if this is normal, but I do like it.
01-24-2014, 04:29 PM
Glad to see your Dr recommended this run just as I mentioned the combination in the other log. I will be watching to see how your adjusting and feeling taking this if you plan on updating.
01-24-2014, 04:32 PM
Yeah, the timing of my call to him and your thread, amongst others that have posted, is interesting. I never would have thought of it.
01-24-2014, 04:34 PM
01-24-2014, 04:42 PM
Nothing I have not already achieved. I have been on for a little over 3 years and it's the best decision I have ever made.
I should add that I am very active and have been lifting seriously for 22 years, so this didn't change that aspect, but it does allow me to do it at nearly the same level as I did at 25. As most of nearing or in our 40s understand is that so many guys just start falling apart around 30ish and there becomes a choice of giving in to nature or kicking nature in the ass and saying "not this guy".
01-24-2014, 09:34 PM
Ok, Onlychevy6, let me ask you this: what do you feel on a day to day basis with preg and dhea? I mean, I have only taken this today and it feels almost recreational. My wife asked what I was on and my coworker told me I was smiling all day. I find it hard to believe that this could be a daily feeling because it is so happy and energizing.
What has been your experience?
01-25-2014, 10:26 PM
01-25-2014, 11:57 PM
Yeah buddy, today was wonderful as well. I feel almost embarrassed that I dismissed these two additional pieces to TRT and did not talk about it with my doc earlier. I guess it is all a learning experience along the way. All I know is that I thank you and others for bringing it up because it made me start reading all the doctors that are now supporting this. I'm also glad I happened to call my own doc yesterday.
01-27-2014, 06:13 PM
Well 4 days in and I called my doc to thank him. I feel like a completely different person. I thought I was feeling great on just test, and rightfully so, I was. But now I have more energy than I know what to do with, my memory and recall is already significantly better, and I am very level. I like to think of it as balanced. I just feel really balanced and like I am firing on all cylinders. The thing that is really blowing me away is my mental clarity and the ability to find words I don't even know where I learned from- they just pop in my head. Also, situations that slight anxiety would creep in (board meeting today), felt calm and ready for.
01-27-2014, 06:14 PM
01-27-2014, 06:37 PM
01-27-2014, 06:45 PM
01-27-2014, 07:41 PM
I have a brand new bottle of 100mg pregnenolone capsules, I'll give them a try. Should maybe break open the capsule and sprinkle half the contents under my tongue?
I've also got a brand new bottle of 15mg DHEA cream. I'll try them both out for a few days and let you guys know.
01-27-2014, 09:02 PM
I've started taking DHEA and PREG transdermally again. It used to give me acne but I'm fine now with it and do feel better. It's Dermacrine, just under two pumps. I've definitely needed it cos my adrenals are shot and DHEA has always been low for ages.
01-27-2014, 09:20 PM
I have been taking a single 50mg in the morning with 25mg of DHEA at around 6am on an empty stomach. Not once in 4 days have I felt a slight bit lazy or unmotivated until I start unwinding around 10pm or so.
01-27-2014, 11:25 PM
Thanks for sharing your experience man- glad you are loving it!
I have a bottle of Dermacrine and a bottle Transaderm now I'm looking forward to starting these.
Beau how come you don't think the transdermals will give the same effect?
01-27-2014, 11:28 PM
Again, I will have to see if I can find it. I'll look. It may have something to do with transdermal DHEA not convertinh to DHEA-S.
But, honestly, I will have to "re-find" the study.
Purportedly there are ways of increasing DHEA transdermally, via "magnesium oil" (which is actually not an oil). I have no experience with this, and know some believe it is snake oil. But, for example, Mike Mahler believes transdermal magnesium oil is the best way to boost DHEA "naturally".
But as to oral administration:
Oral DHEA does work, at least following HIIT.
Eur. J. Appl. Physiol., 2013
Effect of acute DHEA administration on free testosterone in middle-aged and young men following high-intensity interval training
Liu, TC; Lin, CH; Huang, CY; Ivy, JL; Kuo, CH
With advancing age, plasma testosterone levels decline, with free testosterone levels declining more significantly than total testosterone. This fall is thought to underlie the development of physical and mental weakness that occurs with advancing age. In addition, vigorous exercise can also lower total and free testosterone levels with the decline greatest in physically untrained men.
The purpose of the study was to evaluate the effect of oral DHEA supplementation, a testosterone precursor, on free testosterone in sedentary middle-aged men during recovery from a high-intensity interval training (HIIT) bout of exercise. A randomized, double-blind, placebo-controlled crossover study was conducted for 8 middle-aged participants (aged 49.3 ? 2.4 years) and an additional 8 young control participants (aged 21.4 ? 0.3 years). Each participant received DHEA (50 mg) and placebo on separate occasions one night (12 h) before a 5-session, 2-min cycling exercise (100 % [Formula: see text]).
While no significant age difference in total testosterone was found, middle-aged participants exhibited significantly lower free testosterone and greater luteinizing hormone (LH) levels than the young control group. Oral DHEA supplementation increased circulating DHEA-S and free testosterone levels well above baseline in the middle-aged group, with no significant effect on total testosterone levels. Total testosterone and DHEA-S dropped significantly until 24 h after HIIT for both age groups, while free testosterone of DHEA-supplemented middle-aged men remained unaffected.
These results demonstrate acute oral DHEA supplementation can elevate free testosterone levels in middle-aged men and prevent it from declining during HIIT. Therefore, DHEA supplementation may have significant benefits related to HIIT adaptation.
In addition, I've just learned that DHEA can lower SHBG. This, of course, would lead to a rise in free testosterone.
"The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women"
"While on DHEA, serum SHBG levels declined with a greater (P < 0.02) response in women (−40 ± 8%; P = 0.002) than in men (−5 ± 4%; P = 0.02)."
01-27-2014, 11:38 PM
I had never heard of Dermacrine, but that is some expensive stuff for the ingredient profile ( and only 3.6mg preg)and would be hard to really know how much you are getting of each ingredient. If I am messing with something that is obviously a very powerful hormone, I want to know what I am taking. Pregnolone and DHEA are no joke.
Not saying don't take it, but there is a cheaper and more accurate way once that is gone by buying the ingredients separate.
There is no question in my mind that oral DHEA works, and I highly doubt that endos would continue telling patients to use it if labs weren't proving it so. Also, I am on TRT, so the effect I am getting may be greater than those that are not.
01-28-2014, 12:26 AM
01-28-2014, 12:31 AM
01-28-2014, 12:33 AM
I'm cutting up soon can't decide if I wanna go all natural or use something like dermacrine, formeron and 11 keto
01-28-2014, 12:45 AM
01-28-2014, 12:48 AM
You don't need as much of the active when using transderamally. It absorbs much more this way. I don't have the percentages off the top of my head though.
Oral DHEA simply converts too much to estrogen though. I don't agree with it one bit. This has been covered on this forum in depth before. Transdermal is far superior, sublingual 2nd best, oral is the worst.
01-28-2014, 01:30 AM
01-28-2014, 02:48 AM
01-28-2014, 07:18 AM
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