I was recently at my PCP for an anual male wellness check-up. This included a general annual exam which included the usual CMP, CBC, PSA, Lipid, digital prostate exam as well as Total/Free testosterone, LH, and prolactin (she knows I am a TRT patient - not complete but she is my PCP) and I requested a full cardio exam (stress test, echo, etc).
The interesting thing was aside from my test being on the high range (she is a PCP so i did not argue the point) my prolactin was at 25.2 (2.5-22.5 Senora Quest). I am by no means symptomatic. But I did find this to be quite concerning in general as I have been a frequent user and sometimes over user of the prescription sleep aid Temazepam and the OTC Unison (Doxylamine Succinate) and recently prescribed Trazadone (an alternate to Temazepam) and just today filled a trial prescription of Buspar (busporine) for stress and anxiety.
It does seem that this is not a casual correlation.
The neuro-endocrine impact of 3-hy... [Psychopharmacology (Berl). 1983] - PubMed - NCBI
Trazodone treatment increases plasm... [Int Clin Psychopharmacol. 1995] - PubMed - NCBI
Increased prolactin response to buspirone in... [J Affect Disord. 1996] - PubMed - NCBI
Unisom (Doxylamine Succinate) is also a culprit but I do not have any references.
It appears that it is an issue with drugs that are D25-HT1A, serotonin and/or dopamine D2 receptor agonist (beyond my knowledge of physiology).
She immediately mentioned bromocriptine and another (not cabergoline) to reduce prolactin. Of course we discussed the benign pituitary edenoma but as recently as four to five years ago I had my hypogonadal pre-treatment pituitary MRI that was negative at the time.
This is more of an FYI post and not a how can I solve this mystery. My plan is to cease use of said drugs and retest in 6 to 8 weeks. But I just thought I would share.