I've been on 125mg e6d for over a year now with great results and no E2 problems, but I wasn't convinced that I needed to be that high because recent blood work showed I was in the 1200-1300 range a few days after inject. So I decided a few weeks ago to lower to 100mg e6d. I can honestly say, that I can't believe the difference. I feel absolutely amazing, libido through the roof, and no agitation at all. I'll be getting bloods in a month or so, but it really has made a big difference.
Thought I'd share since I have experience on TRT (it will be 2 years come spring) and have been slowly lowering my test doses with better and better results.