After spending lunch last 5 hours with a very well respect lyme specialist, I am.rethinking assessing vitamin d recommendations We have been checking the 25 oh levels and basing recommendations on that which has been total miss.leading. One needs to look at 1,25 and 25 d together. If ratio is > 1.5 then supplementation should be stop. By having a higher ratio one is putting them in a proinflammatory state causing alterations in th1/th2 in balance...vitamin d.may make you feel good.because is a quasi hormone, but may be masking something deeper. Often times when evaluating cases I see high calcium in serum, but never knew what it could be from. The common treatment believe it or not is adrenals which are usually supporting. Now knowing this information I will be looking deeper at the potential pro inflammatory response. not recommending vitamin d. It has to do with effect on vdr response.by effecting antimicrobial antibodies response. Specially a concern in viral or pathogen infection. By changing the ratio of vitamin d 25:1,25 one sees a significant change in inflammation markers..so it does.make sense in the proper situation