I've decided to start taking SAM-E again, mainly to aid sulfation of glucosamine to help aid recovery from a shoulder surgery I had recently. I am taking 1600MG daily, for a month now, with no adverse effects. I expected anxiety or something at this level, but haven't experienced it.
My questions are, what should I take with it in order to lower homosystein? Is methyl-folate fine on it's own for this purpose? Or is that too many methyl donors to be taking? Anything else I may want to take along side it?
Does anyone know of any adverse effects when taking SAM-E at such a high dose? I didn't' even really ease into it. I started with 800MG for a couple days then went straight to 1600MG (of active form). Any suggestions welcome, as I expect to take this for many months.