While attending a Neuroscience seminar last night with multiple medical professionals, I ran into a PH.D of pharmacology. We started talking about gels and TD application as to the potential reason they do not work or give inconsistant results. We explored different types of carriers, bases , application sites still not getting a definitive answer. Then she mentioned "do you rotate sites"? I showed her how some well known HRT Dr's and compounding pharmacist noted to apply the gels. She replied "that's great, but the only problem is the area can be super saturated in a matter of a few days with some people, by rotating 4 different sites over the body this reduces the chance of down regulation of the delivery of the drug allowing for optimal absorption" I noted "This could possible explain the 1-2 week rush get on a Topical testosteorne?" She told me absolutely. So all the people taking androgel, T gels applying it to one area only may want to start rotating sites, Legs, calves shoulders, ect this might result in better absoprtion and plasma levels. Again some times the most complex problems have the simplest answers.