When you are testing estradiiol sensitive be very cautious about Lab corp, I had 2 testing done back to back from them in a month period and got same read 23. Thinking this was good I ruled out estrogen imbalances, but I still had bloating and some usually symptoms related to high e2 which I could just brushed off as my thyroid, Which was found to be perfect. Since I have been on the same protocol of supplements for past 2-3 months I decided to go get tested at quest diagnostics because I have been having slight muscle weakness and losing muscle mass at a gradual steady decline. I got tested estradiol and CPK and to my shock my e2 sensitive from quest was 49 !! and my CPK was almost 150 points over the top range. I had not worked out for 5 days so I do not think it was that. My thyroid was fine so that was ruled out, but high e2 will not allow your muscle to repair at a normal rate. I came to the conclusion, lab corp sensitive testing is deviated 10-20 points below what your normal levels are recording. I am not the only one this has been happening to but alot of other peoples on the boards have been complaining as well getting false readings especially when symptoms are present. One can have optimal sex drive at the same time experience other e2 related symptoms (I have been losing dreams for longest time despite take high dosages of P5P)