I was on axiron, and the first week or two I could definitely feel something. My t levels were 330, i'm 31 years old, but take also lots of other things for bipolar disorder. My mood improved with axiron enough that I asked my pdoc to decrease my bupropion dose. I had lots of sexythoughts. However, after 2-3 weeks, the effect went away, and sure enough, 6 weeks into it, I went back to endocrinologist and got T results, and it had gone DOWN 10 points to 321! I had also tried androgel in the past which didn't feel like it did anything. Endocrinologist said triple the dose to one swipe under each underarm 3x a day, i've been doing that last two weeks. Have no problem getting it up or staying hard or ejaculating but energy levels and desire and interest and mood are still quite low. my experience could be unique though since I'm on so many other things for bipolar disorder and taking other supplements.