Hormone Pathway

  1. bigironkiller's Avatar
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    Hormone Pathway


    Can an enzyme deficiency be cause of hypogonadism? Specifically a p450 enzyme deficiency. It is my understanding the the p450 enzyme converts cholesterol into pregnenolone then testosterone and others.

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    Philec48's Avatar
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    Yep:

    http://www.ncbi.nlm.nih.gov/bookshel...=gene&part=abs

    Since this condition affects all hormones, looking at cortisol, dhea, progesterone, etc... can help confirm it. A DNA test may be needed for conclusive confirmation.

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