SHBG

  1. bigironkiller's Avatar
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    SHBG


    Been searching but cant find a chart that shows at what rate/percent SHBG binds to testosterone. Anyone led me in the right direction....

    Here is a scenario:

    Guy 1: total T of 300 ng/dL
    SHBG 10 nmol/L
    -what is his free/bio-available testosterone

    Guy 2: total T of 750 ng/dL
    SHBG 30 nmol/L
    -what is his free/bio-available testosterone

    Does guy 1 or 2 have the most bio-available testosterone???

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    guy 1 228 ng/dL = 76 %

    guy 2 422 ng/dL = 56.2 %

    assumes constant 4.3 g/l of albumin

    http://www.issam.ch/freetesto.htm
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    Here is one of my 1st blood tests back from 06' right before my diagnosis of hypogonadism at 22yrs old.

    Only the testosterone ranges:

    free androgen index:
    albumin. 5.0g/dL. Range 3.5-5.1
    total testosterone. 291ng/dL. Range 262-1593
    SHBG. 8.6nmol/L. Range 13-71
    free androgen index. 117.4. Range 29-188
    free testosterone(calc). 30%
    bioavailable testosterone(calc). 80.5%


    What is the difference between free and bioavailable testosterone? And do those %'s even look right? Does my very low SHBG make up for the low total testosterone making me not hypogonadic or ?????
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    Janzs, Matrix

    anyone
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    . What are free and bioavailable testosterone?
    Testosterone is present in the blood as "free" testosterone (1-4%) or bound testosterone. The latter may be loosely bound to albumin, a serum protein, or bound to a specific binding protein called Sex Steroid Binding Globulin (SSBG) or Sex Hormone Binding Globulin (SHBG). The binding between testosterone and albumin is not very strong and is easily reversed; so the term bioavailable testosterone (BAT) refers to the sum of free testosterone plus albumin-bound testosterone

    http://www.labtestsonline.org/unders...one/faq.html#4
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    Quote Originally Posted by bigironkiller View Post
    Here is one of my 1st blood tests back from 06' right before my diagnosis of hypogonadism at 22yrs old.

    Only the testosterone ranges:

    free androgen index:
    albumin. 5.0g/dL. Range 3.5-5.1
    total testosterone. 291ng/dL. Range 262-1593
    SHBG. 8.6nmol/L. Range 13-71
    free androgen index. 117.4. Range 29-188
    free testosterone(calc). 30%
    bioavailable testosterone(calc). 80.5%


    What is the difference between free and bioavailable testosterone? And do those %'s even look right? Does my very low SHBG make up for the low total testosterone making me not hypogonadic or ?????
    Low SHBG sometimes is due to thyroid problems..

    I suggest that you consider doing once over checkup,
    that would figure out your weak spots.

    Do my complete list.
    Do Specracell-5000
    do Fatty Acid Analysis

    post results

    then I will be able to give you better directions.

    .................
  7. bigironkiller's Avatar
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    Couple of follow up questions:

    1. I read that low SHBG can cause hypermetabolization of testosterone
    -what happens to testosterone that is hypermetabolized
    -is there a blood test to check for hypermetabolism of any kind
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    Also is there any sublingual TRT meds available and are they better than injections?
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    Quote Originally Posted by bigironkiller View Post
    Couple of follow up questions:

    1. I read that low SHBG can cause hypermetabolization of testosterone
    -what happens to testosterone that is hypermetabolized
    -is there a blood test to check for hypermetabolism of any kind
    Do in the same day

    blood test
    and
    24hr-urine RheinLabs test

    you may have a little testosterone in the blood
    and a lot in urine

    means that lots of testosterone is wasted before it can do its job.


    ...
    If that is the case
    the only thing that I know of that may help is,
    very frequent,
    very small amounts,
    sometimes daily test injections.

    I know of some that use transdermal-T 2x/day

    ............
    Cobalt drops have been suggested by dr Johnathan Wrigth.

    I know of couple guys who tried those drops, little success.

    Very frequent, very small, T applications is the only solution that works.
    ============================== ========

    Having low SHBG
    one have to use testosterone gingerly.

    High testosterone levels suppress SHBG and pushes it down even lower.

    //////////
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    Jansz any idea what that spectracell test costs? They dont promote it much. Is it worth doing?

    http://www.spectracell.com/
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    Quote Originally Posted by spinn View Post
    Jansz any idea what that spectracell test costs? They dont promote it much. Is it worth doing?

    http://www.spectracell.com/
    I asked my doc for that test.
    To humor me, he opened account with Spectracell.
    About cost.
    The way it works, they check first how much insurance will cover
    and ask for the difference, before the blood is drawn.
    It cost me $70 out of pocket (about $370 original cost)

    =============================
    A: Most private indemnity insurance carriers cover micronutrient testing including PPO, EPO and POS plans. Patients are responsible for co-payments and are invoiced by SpectraCell for this fee. Patients who have not met their deductible also receive an invoice from SpectraCell.

    ........................

    Without doctor, you may find local draw site using their web site.
    To order FIA™ test kits call at 713-621-3101 or toll free at 800-227-5227

    They accept credit card payments.

    They provide different (less $$) levels of testing.
    I would not bother, get the whole thing or nothing.

    FIA Comprehensive Profile 5000
    Comprehensive Nutritional Panel
    Lipoprotein Particle Profile (LPP)


    ....
    Nutritional Considerations of Endocrinology Part 2 (Men's Health)

    • What nutritional similarities are found between Diabetes Mellitus and Thyroid Dysfunction?

    • Are you aware of certain mineral deficiencies related to Thyroid Dysfunction?

    • How commonly prescribed medications for Diabetes Mellitus could be related to nutritional deficiencies and neuropathy.
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    Couple of years ago I tried the buccal testosterone that you hold between your gum and cheek throughout the day.

    Not a pleasant experience. It melts a little and gets sticky, not to mention the aggravation of feeling something constantly sitting there. Plus, it can get gross when eating.

    Self-injections are a breath of fresh air in comparison.

    Why? Are injections not working for you? Maybe you need to adjust the dose and/or inject more often to get stable levels.

    Quote Originally Posted by bigironkiller View Post
    Also is there any sublingual TRT meds available and are they better than injections?
  13. bigironkiller's Avatar
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    Injections are working fine. I just recently switched to subQ injections EOD and feel much better. Just looking for new options.
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    Looks like you found the best option. :-)

    Much better? I may need to switch to EOD myself then to see if it makes a difference. Sometimes I think my body is numb. Taking testosterone, and Cytomel for thyroid is making me feel only about a humming bird's difference better.
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    Quote Originally Posted by Philec48 View Post
    Looks like you found the best option. :-)

    Much better? I may need to switch to EOD myself then to see if it makes a difference. Sometimes I think my body is numb. Taking testosterone, and Cytomel for thyroid is making me feel only about a humming bird's difference better.
    Depends on the symptoms because e2 also plays into this factor as well as multiple others.
    I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
  

  
 

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