- 02-08-2010, 06:44 PM
Been searching but cant find a chart that shows at what rate/percent SHBG binds to testosterone. Anyone led me in the right direction....
Here is a scenario:
Guy 1: total T of 300 ng/dL
SHBG 10 nmol/L
-what is his free/bio-available testosterone
Guy 2: total T of 750 ng/dL
SHBG 30 nmol/L
-what is his free/bio-available testosterone
Does guy 1 or 2 have the most bio-available testosterone???
- 02-08-2010, 09:13 PM
- 02-08-2010, 10:09 PM
Here is one of my 1st blood tests back from 06' right before my diagnosis of hypogonadism at 22yrs old.
Only the testosterone ranges:
free androgen index:
albumin. 5.0g/dL. Range 3.5-5.1
total testosterone. 291ng/dL. Range 262-1593
SHBG. 8.6nmol/L. Range 13-71
free androgen index. 117.4. Range 29-188
free testosterone(calc). 30%
bioavailable testosterone(calc). 80.5%
What is the difference between free and bioavailable testosterone? And do those %'s even look right? Does my very low SHBG make up for the low total testosterone making me not hypogonadic or ?????
02-09-2010, 10:01 AM
02-09-2010, 12:03 PM
. What are free and bioavailable testosterone?
Testosterone is present in the blood as "free" testosterone (1-4%) or bound testosterone. The latter may be loosely bound to albumin, a serum protein, or bound to a specific binding protein called Sex Steroid Binding Globulin (SSBG) or Sex Hormone Binding Globulin (SHBG). The binding between testosterone and albumin is not very strong and is easily reversed; so the term bioavailable testosterone (BAT) refers to the sum of free testosterone plus albumin-bound testosterone
02-09-2010, 06:37 PM
I suggest that you consider doing once over checkup,
that would figure out your weak spots.
Do my complete list.
do Fatty Acid Analysis
then I will be able to give you better directions.
02-09-2010, 10:02 PM
Couple of follow up questions:
1. I read that low SHBG can cause hypermetabolization of testosterone
-what happens to testosterone that is hypermetabolized
-is there a blood test to check for hypermetabolism of any kind
02-10-2010, 01:59 AM
Also is there any sublingual TRT meds available and are they better than injections?
02-10-2010, 09:20 AM
24hr-urine RheinLabs test
you may have a little testosterone in the blood
and a lot in urine
means that lots of testosterone is wasted before it can do its job.
If that is the case
the only thing that I know of that may help is,
very small amounts,
sometimes daily test injections.
I know of some that use transdermal-T 2x/day
Cobalt drops have been suggested by dr Johnathan Wrigth.
I know of couple guys who tried those drops, little success.
Very frequent, very small, T applications is the only solution that works.
Having low SHBG
one have to use testosterone gingerly.
High testosterone levels suppress SHBG and pushes it down even lower.
02-10-2010, 10:01 AM
02-10-2010, 10:23 AM
To humor me, he opened account with Spectracell.
The way it works, they check first how much insurance will cover
and ask for the difference, before the blood is drawn.
It cost me $70 out of pocket (about $370 original cost)
A: Most private indemnity insurance carriers cover micronutrient testing including PPO, EPO and POS plans. Patients are responsible for co-payments and are invoiced by SpectraCell for this fee. Patients who have not met their deductible also receive an invoice from SpectraCell.
Without doctor, you may find local draw site using their web site.
To order FIA™ test kits call at 713-621-3101 or toll free at 800-227-5227
They accept credit card payments.
They provide different (less $$) levels of testing.
I would not bother, get the whole thing or nothing.
FIA Comprehensive Profile 5000
Comprehensive Nutritional Panel
Lipoprotein Particle Profile (LPP)
Nutritional Considerations of Endocrinology Part 2 (Men's Health)
• What nutritional similarities are found between Diabetes Mellitus and Thyroid Dysfunction?
• Are you aware of certain mineral deficiencies related to Thyroid Dysfunction?
• How commonly prescribed medications for Diabetes Mellitus could be related to nutritional deficiencies and neuropathy.
02-10-2010, 11:38 PM
Couple of years ago I tried the buccal testosterone that you hold between your gum and cheek throughout the day.
Not a pleasant experience. It melts a little and gets sticky, not to mention the aggravation of feeling something constantly sitting there. Plus, it can get gross when eating.
Self-injections are a breath of fresh air in comparison.
Why? Are injections not working for you? Maybe you need to adjust the dose and/or inject more often to get stable levels.
02-11-2010, 12:31 AM
Injections are working fine. I just recently switched to subQ injections EOD and feel much better. Just looking for new options.
02-12-2010, 01:13 AM
Looks like you found the best option. :-)
Much better? I may need to switch to EOD myself then to see if it makes a difference. Sometimes I think my body is numb. Taking testosterone, and Cytomel for thyroid is making me feel only about a humming bird's difference better.
02-18-2010, 08:51 AM
I am not a medical Dr, please keep in mind that this answer is for information purposes only, and is not intended to diagnose, treat or replace sound medical advice from your physician or health care provider.
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