I've been doing alot of reading on pregnenolone and adrenal hormones in general. So far i've noticed Crisler recommends TD Preg, and other Dr's still recommend Oral. I have also put together that some people respond / feel better on either one depending on the person.
I've read posts from people about how topical dhea didnt budge their dhea numbers, yet oral sky rocketed it due to the conversion to DHEAS which acts as a reservoir of sorts that the body can use when needed by pulling the Sulfate off of the DHEA.
Im assuming, but not positive that pregnenolone might work in the same way since a metabolite of pregnenolone is PREGS the Sulfated form. I cant find any information regarding the half life of PREGS, but if it works anything like DHEA than oral may be the best way to take it to avoid the enzyme reactions that take place through transdermal use, and build up a "reservoir of PREGS".
If anyone else has any information about the two i'd greatly appreciate it, thanks.