How long is the half life of Anastrozole (liquidex)

[b4554]

and how soon does it start to work and how long is it's total effective duration?

Also, how long after application of compounded t-cream does it start to effectively enter the blood stream?

Thanks

 

[Yellow]

arimidex / liquidex (anaztrozole) half-life is 72 Hours.

 

[The Matrix]

arimidex / liquidex (anaztrozole) half-life is 72 Hours.

Try more like 50 hours ..

 

[jinxie]

Try more like 50 hours ..

46.8 hrs. Wiki has it wrong; Matrix has it right.

http://jcem.endojournals.org/cgi/content/abstract/94/8/2975

 

[crazyfool405]

yea just about 2 days i still have to use .5mg ED to keep gyno down though

 

[The Matrix]

46.8 hrs. Wiki has it wrong; Matrix has it right.

http://jcem.endojournals.org/cgi/content/abstract/94/8/2975

How often have I been wrong :18:
More so the Dr's are often wrong with way they handle specific cases.

 

[jinxie]

yea just about 2 days i still have to use .5mg ED to keep gyno down though

Have you tested your lipids since taking 3.5 mgs per week? That's a high dose to be taking long term, based on what I've read.

 

[ideatrade]

I was told 0.5mg 3 times per week as prescribed by my doctor was too much. My estorodiol was 32 and test was 235. I was told 2 times per week was plenty. A little confused.

 

[jinxie]

I was told 0.5mg 3 times per week as prescribed by my doctor was too much. My estorodiol was 32 and test was 235. I was told 2 times per week was plenty. A little confused.

He was probably trying to make it easy on you, dividing the dose. You'll likely be fine, but I'd switch to 1/3 mg, 3 times per week.

What you really need is hCG or test, as low as your test is.

 

[luclyluciano]

How does Arimidex compare to Formestane? I just finished a bottel of Cel's Formestane & really like the results? Is it worth the effort to get it for cycles or is Form just fine?

 

[jinxie]

How does Arimidex compare to Formestane? I just finished a bottel of Cel's Formestane & really like the results? Is it worth the effort to get it for cycles or is Form just fine?

I doubt there is any comparison as Adex is RX for breast cancer & male gyno. You can get it far cheaper than OTC and a little goes a long way if you are just on HRT.

 

[colkurtz_spf]

He was probably trying to make it easy on you, dividing the dose. You'll likely be fine, but I'd switch to 1/3 mg, 3 times per week.

What you really need is hCG or test, as low as your test is.

I took 5 mg per week for a 4 month period about two years ago and had no change in my lipid profile. I was trying Arimidex therapy VS HCG.

 

[pmgamer18]

Taking to much Arimidex kills your wood gives you some dam bad ED problems. So if your doing a lot and still get night time and morning wood your OK. I gage not going down to low by my night time and morning wood been telling men this for yrs and it works.

 

[jinxie]

I took 5 mg per week for a 4 month period about two years ago and had no change in my lipid profile. I was trying Arimidex therapy VS HCG.

Colkurtz, it wouldn't be the first time you were the exception to rule. For most of us on HRT, 5 mgs of Adex per week (or, for that matter, even 2 mgs) would put our E2 in the gutter (way lower than 20), and this would have an adverse impact on both lipid profile as well as libido. A number of studies have been conducted regarding the relationship between estrogen levels and lipid profile. I don't know whether that's the case with libido, but there is quite a bit of anecdotal evidence on this board.

Off topic: How are you doing on your new, lower hCG regimen, and your fruit diet? (I think we are at about the same hCG dose -- I am at 1,500 IUs per week.)

Hope you are well.

 

[colkurtz_spf]

My E2 was in the gutter at 6, and libido was down, but my lipids were fine. It wasn't the therapy for me. Now I use .5mg twice per week and that works well for me.

My fruit diet is going well. It has become a way of life. I feel very good on the lower dose of HCG.

Colkurtz, it wouldn't be the first time you were the exception to rule. For most of us on HRT, 5 mgs of Adex per week (or, for that matter, even 2 mgs) would put our E2 in the gutter (way lower than 20), and this would have an adverse impact on both lipid profile as well as libido. A number of studies have been conducted regarding the relationship between estrogen levels and lipid profile. I don't know whether that's the case with libido, but there is quite a bit of anecdotal evidence on this board.

Off topic: How are you doing on your new, lower hCG regimen, and your fruit diet? (I think we are at about the same hCG dose -- I am at 1,500 IUs per week.)

Hope you are well.

 

[jinxie]

My E2 was in the gutter at 6, and libido was down, but my lipids were fine. It wasn't the therapy for me. Now I use .5mg twice per week and that works well for me.

My fruit diet is going well. It has become a way of life. I feel very good on the lower dose of HCG.

I think arimidex monotherapy makes a lot of sense for older dudes, particularly those that have a high E2:TT ratio.

 

[colkurtz_spf]

I think arimidex monotherapy makes a lot of sense for older dudes, particularly those that have a high E2:TT ratio.

I guess I'm a poor candidate. My E2 was 16 before starting any kind of TRT. The idea was appealing though. If you travel a lot, pills are much more convenient than injections.

 

[pmgamer18]

I have lost count on how many young men I have told not to go on TRT until they checked there Estradiol levels and when they did it was very high lowering there Testosterone. E's are in the dam air we breath and in the water we drink even in the plastic we eat and drink from. Don't even get me started on the food we eat.

This was posted by one of my new guys at the H2 group it's great and the Video wow I remember this movie.
A cut and Paste.
=====================================
Thank you. I'm as sad as hell, and I'm not taking it anymore....

I don't have to tell you hypogonadism makes you feel sad. Every man with Low-T knows it feels bad. It's a depression. Every Urologist out of wack or scared of losing their licensee. The dollar buys a nickel's worth; banks are going bust; shopkeepers keep a gun under the counter; punks are running wild in the street, and there's nobody anywhere who seems to know what to do, and there's no end to it.

We know the air is unfit to breathe and our ****s are to limp to screw. And we sit reading our local blog local investigative reporter tells us that abdominal fat and osteoporosis is natural, as if that's the way it's supposed to be!

We all know things are bad -- worse than bad -- they're crazy.

It's like everything everywhere is going crazy, so we don't go out any more. We sit in the house, and slowly the world we're living in is getting smaller, and all we say is, "Please, at least leave us alone in our living rooms. Let me have my budeperion my lexapro, my simvastain, and my Viagra and I won't say anything. Just leave us alone."

Well, I'm not going to leave you alone.

I want you to get mad!

I don't want you to protest to your current doctor. I don't want you to get him riled up. I don't want you to write to your insurance company, because I wouldn't know what to tell you to write. I don't know what to do about the depression and the fatigue and the high cholesterol and the in the street.

All I know is that first, you've got to get mad.

You've gotta say, "I'm a human being, goddammit! My life has value!"

So, I want you to get your courage up now. I want all of you to get up out of your chairs. I want you to get up right now and make an appointment with a new Doctor, pick up the phone, and stick your chest and yell, NOW!

"I'm as sad as hell,

and I'm not going to take this anymore!!"

 

[jinxie]

I have lost count on how many young men I have told not to go on TRT until they checked there Estradiol levels and when they did it was very high lowering there Testosterone. E's are in the dam air we breath and in the water we drink even in the plastic we eat and drink from. Don't even get me started on the food we eat.

This was posted by one of my new guys at the H2 group it's great and the Video wow I remember this movie.
A cut and Paste.
=====================================
Thank you. I'm as sad as hell, and I'm not taking it anymore....

I don't have to tell you hypogonadism makes you feel sad. Every man with Low-T knows it feels bad. It's a depression. Every Urologist out of wack or scared of losing their licensee. The dollar buys a nickel's worth; banks are going bust; shopkeepers keep a gun under the counter; punks are running wild in the street, and there's nobody anywhere who seems to know what to do, and there's no end to it.

We know the air is unfit to breathe and our ****s are to limp to screw. And we sit reading our local blog local investigative reporter tells us that abdominal fat and osteoporosis is natural, as if that's the way it's supposed to be!

We all know things are bad -- worse than bad -- they're crazy.

It's like everything everywhere is going crazy, so we don't go out any more. We sit in the house, and slowly the world we're living in is getting smaller, and all we say is, "Please, at least leave us alone in our living rooms. Let me have my budeperion my lexapro, my simvastain, and my Viagra and I won't say anything. Just leave us alone."

Well, I'm not going to leave you alone.

I want you to get mad!

I don't want you to protest to your current doctor. I don't want you to get him riled up. I don't want you to write to your insurance company, because I wouldn't know what to tell you to write. I don't know what to do about the depression and the fatigue and the high cholesterol and the in the street.

All I know is that first, you've got to get mad.

You've gotta say, "I'm a human being, goddammit! My life has value!"

So, I want you to get your courage up now. I want all of you to get up out of your chairs. I want you to get up right now and make an appointment with a new Doctor, pick up the phone, and stick your chest and yell, NOW!

"I'm as sad as hell,

and I'm not going to take this anymore!!"

The dude sounds like a shackled Marxist proletariat. And it sounds like the low T has made him a little batty.

No disrespect directed at you, Phil. I just don't don't really relate to the whole "we're not going to take it anymore" speeches. Words are cheap. The guy needs to man up and advocate for himself, and should encourage others to do the same, minus the diatribe. He could say it in a single paragraph, without all the histrionics and drama.

But hey, we all come to forums for different reasons; I suppose some just come for affirmation and attention. "WELL I'M NOT GOING TO TAKE IT ANYMORE. MY TIME HAS VALUE, AND I AIN'T READING NO POSTS WRITTEN BY WHINY BITCHES." (I actually read it because you posted it, Phil.)

 

[colkurtz_spf]

The dude sounds like a shackled Marxist proletariat. And it sounds like the low T has made him a little batty.

No disrespect directed at you, Phil. I just don't don't really relate to the whole "we're not going to take it anymore" speeches. Words are cheap. The guy needs to man up and advocate for himself, and should encourage others to do the same, minus the diatribe. He could say it in a single paragraph, without all the histrionics and drama.

But hey, we all come to forums for different reasons; I suppose some just come for affirmation and attention. "WELL I'M NOT GOING TO TAKE IT ANYMORE. MY TIME HAS VALUE, AND I AIN'T READING NO POSTS WRITTEN BY WHINY BITCHES." (I actually read it because you posted it, Phil.)

It's a play on words from Network, a movie released in 1976 starring Peter Finch. http://www.imdb.com/title/tt0074958/

I must confess. I'm a little mad. The environment has screwed an entire generation out of its manhood and no one talks about it. Certainly not the AMA.

 

[jinxie]

It's a play on words from Network, a movie released in 1976 starring Peter Finch. http://www.imdb.com/title/tt0074958/

I must confess. I'm a little mad. The environment has screwed an entire generation out of its manhood and no one talks about it. Certainly not the AMA.

Nice catch. That puts things in better perspective. I think I may have seen a remake of that film, but I am unsure.

The Boomers were taught to suck it up, and just take it, as it was their parents who lived through the depression. Our medical system has not been about optimization for some time. It wasn't always like that. There used to be all sorts of elixirs. And then reefer madness, and we turned into a bunch of tight asses where medicine is concerned. I think it spans far beyond hormonal therapies. In fact I know it does, as someone who suffers from chronic illness (which cross multiple medical disciplines/specialties) that took several years of staunch advocacy and research to finally educate my treating physicians so that I could be sent to the appropriate specialist to help me reclaim my healthy. For me, HRT was only a small fraction of the formula.

 

[pmgamer18]

We all need to be mad as hel* I have a new guy at the Yahoo H2 forum that I mod at he has been on TRT for 7 yrs. His Dr. retired and the new Dr. told him he will not renew his meds for TRT unles he stops it for 2 weeks so he can get a base line test. WTF is with them dam Dr.'s if they don't know what there doing say so. Would any Dr. do this to a diabetic tell him to stop his meds so they can see how low he will go. Yes the Cut and Paste says it all we need to get mad as Hel* and let them Dr.'s know it.

 

[jinxie]

We all need to be mad as hel* I have a new guy at the Yahoo H2 forum that I mod at he has been on TRT for 7 yrs. His Dr. retired and the new Dr. told him he will not renew his meds for TRT unles he stops it for 2 weeks so he can get a base line test. WTF is with them dam Dr.'s if they don't know what there doing say so. Would any Dr. do this to a diabetic tell him to stop his meds so they can see how low he will go. Yes the Cut and Paste says it all we need to get mad as Hel* and let them Dr.'s know it.

Phil, I have to disagree with you. Insulin is far different than testosterone from the perspective of the regulatory agencies. And I can see why a doc would hesitate before RXing test. Who knows whether this guy is telling the whole story. I would bet that if he had pre-test blood work, revealing low T (like below 400, not below 600; or free-T under 48), then the doc would not require the two weeks off.

Everyone likes to act like Test is the be-all end-all cure for all maladies, and that it solves all problems, just as everyone on Stop the Thyroid Madness thinks natural thryoid is a panacea. Well, I call bull****. There are countless people on both boards that take this magic elixirs and they are hardly cured. Indeed, sometimes it only creates more problems.

Having age-appropriate or optimal test levels is but one piece of the puzzle.

 

[pmgamer18]

You have a good point there in my case I seen 7 Endo's in the last 27 yrs took my labs with me they did not want to see them told me some Bull that my labs are no good I need to come off TRT so they can get a base line level at there labs and there labs are not on my BCBS list so it cost me big money. Every time I let an Endo do this to me I crash so bad I ended up off work in sick leave and all the dam Endo found out was how dam sick he made me. I can't tell you about others but for me it dam near killed me last Nov. when I had Heart bypass sugary and the Dr. that did this took me off hormones and let me crash. Never told my wife he was doing this or my Family Dr.

I come too after the bypass but in a week I was back under the knife do to the wire they used to hold my chest together got infected in the bone. And this Dr. told my wife the reason this happened was do to the Steroids I was taking. I was on TRT yes they are Steroids but come on the reason I got infected was because he took me off TRT.

I have talked a lot of men on TRT that were not doing well because there Dr. was not up on doing TRT so they would send them to see an Endo and each poster said the same thing I just said they would not look at there labs and wanted them off TRT for what they called a Base Line test sorry but there is not such thing and it is criminal to do this to some one on TRT.

Now the sad thing about each Endo that did this to me they still did not get it right each one told me I am Primary and later after 23 yrs of this crap I find out I am Secondary.

 

[jinxie]

You have a good point there in my case I seen 7 Endo's in the last 27 yrs took my labs with me they did not want to see them told me some Bull that my labs are no good I need to come off TRT so they can get a base line level at there labs and there labs are not on my BCBS list so it cost me big money. Every time I let an Endo do this to me I crash so bad I ended up off work in sick leave and all the dam Endo found out was how dam sick he made me. I can't tell you about others but for me it dam near killed me last Nov. when I had Heart bypass sugary and the Dr. that did this took me off hormones and let me crash. Never told my wife he was doing this or my Family Dr.

I come too after the bypass but in a week I was back under the knife do to the wire they used to hold my chest together got infected in the bone. And this Dr. told my wife the reason this happened was do to the Steroids I was taking. I was on TRT yes they are Steroids but come on the reason I got infected was because he took me off TRT.

I have talked a lot of men on TRT that were not doing well because there Dr. was not up on doing TRT so they would send them to see an Endo and each poster said the same thing I just said they would not look at there labs and wanted them off TRT for what they called a Base Line test sorry but there is not such thing and it is criminal to do this to some one on TRT.

Now the sad thing about each Endo that did this to me they still did not get it right each one told me I am Primary and later after 23 yrs of this crap I find out I am Secondary.

Phil, you've had a rough go of it, and I am sorry that your medical care was not better, as you deserve.

Are you sure the doc was not talking about your use of Cortef (HC) when he mentioned that steroids impeded your body's ability to fight infection?

I continue to think that the docs that are handing out HC like candy are committing a gross misjustice to their patients. You must be very careful with the stuff, or you will shut down your body's ability to produce cortisol.

 

[pmgamer18]

I have no Idea about the cortisol before going on cortef I was sick all winter long with everything that was going around bronchitis dam near killed the that last winter before going on Cortef. After this I was never sick in the winter again. Have you read Dr. Jefferies book "Safe Uses of Cortiol" in his book he states the when on is low on Cortisol there imune system is low adding this helps it.

Here is a link to the best parts in his book. I don't know where you get your info but Dr.'s are not handing out HC like Candy people I talk to can't get there Dr. to treat there bad Adrenals. And being on HC helps the body fight infection if the Heart Dr. was talking about the HC I was on then why did he leave me on it and before they put me under they gave me big shots of HC so I did not go into Adrenal shock.

http://www.stopthethyroidmadness.com/safe-uses

 

[living2die]

haha yeh, I thought for a second that I was reading In Dubious Battle by John Steinbeck. Sounds exactly like something Mac would say about the exploitation of the worker.

I have lost count on how many young men I have told not to go on TRT until they checked there Estradiol levels and when they did it was very high lowering there Testosterone. E's are in the dam air we breath and in the water we drink even in the plastic we eat and drink from. Don't even get me started on the food we eat.

This was posted by one of my new guys at the H2 group it's great and the Video wow I remember this movie.
A cut and Paste.
=====================================
Thank you. I'm as sad as hell, and I'm not taking it anymore....

I don't have to tell you hypogonadism makes you feel sad. Every man with Low-T knows it feels bad. It's a depression. Every Urologist out of wack or scared of losing their licensee. The dollar buys a nickel's worth; banks are going bust; shopkeepers keep a gun under the counter; punks are running wild in the street, and there's nobody anywhere who seems to know what to do, and there's no end to it.

We know the air is unfit to breathe and our ****s are to limp to screw. And we sit reading our local blog local investigative reporter tells us that abdominal fat and osteoporosis is natural, as if that's the way it's supposed to be!

We all know things are bad -- worse than bad -- they're crazy.

It's like everything everywhere is going crazy, so we don't go out any more. We sit in the house, and slowly the world we're living in is getting smaller, and all we say is, "Please, at least leave us alone in our living rooms. Let me have my budeperion my lexapro, my simvastain, and my Viagra and I won't say anything. Just leave us alone."

Well, I'm not going to leave you alone.

I want you to get mad!

I don't want you to protest to your current doctor. I don't want you to get him riled up. I don't want you to write to your insurance company, because I wouldn't know what to tell you to write. I don't know what to do about the depression and the fatigue and the high cholesterol and the in the street.

All I know is that first, you've got to get mad.

You've gotta say, "I'm a human being, goddammit! My life has value!"

So, I want you to get your courage up now. I want all of you to get up out of your chairs. I want you to get up right now and make an appointment with a new Doctor, pick up the phone, and stick your chest and yell, NOW!

"I'm as sad as hell,

and I'm not going to take this anymore!!"