- 07-21-2009, 07:54 PM
- 07-23-2009, 02:15 PM
- 07-27-2009, 09:00 AM
I was just wondering if anyone if anyone has had any experience with it.
Some of the things I've read are encouraging like the boost in libido and weight loss but I wondered if it was hype.
Also wondering about purity/safety of the available product.
Like I said, just wondering.
Here's something I found on it:
Increases sexual desire and function for men and women:
- Minimal or no undesirable side effects.
- Decrease body fat mass and reduce food intake.
- Induces skin tanning at low doses.
- Potent self-tanner applications.
Melanotan II also known as PT-141 was developed by researchers at the University of Arizona College of Medicine. Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (?-MSH), this hormone provides a therapeutic tan with the ability to lower the risk of skin cancer, (MSH) also plays an important role in regulating sexual arousal in men and women. Melanotan II has the additional effect of decreasing body fat mass. Melanotan II It is a cyclic lactyam analog of alpha-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.
Melanotan II is in a class of peptide hormone known as Melanocortins (MCs). Melanocortins (MCs) are multifunctional peptide hormones that regulate a diversity of physiological functions. MCs have been implicated in sexual function in animals.
A MC analog, Melanotan II (MTII), can enhance sexual function in human males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, MTII works at the level of the brain, thus eliciting a rather natural sexual response with minimal or no undesirable side effects. The actions of the peptide were discovered accidentally while studying the effects of the peptide and related analogs on human skin pigmentation (tanning). Hadley ME (2005).
Melanotan II, PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following subcutaneous administration to healthy male subjects and to patients with erectile dysfunction (ED) who report an inadequate response to Viagra. The erectile response induced by PT-141 was statistically significant at both doses. PT-141 was safe and well tolerated in both studies. The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base.Rosen RC, Diamond LE, Earle DC, Shadiack AM,Molinoff PB (2004).
In addition to the sexual enhancement and tanning effects of Melanotan II, MT-II has also exhibited the potential to decrease body fat mass and reduce food intake. Choi YH, Li C, Hartzell DL, Lin J, Della-Fera MA, Baile CA (2003).
MT-II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection. The recommended single MT-II dose for future Phase I studies is 0.025 mg/kg/day.
07-27-2009, 10:26 AM
07-27-2009, 10:36 AM
- 5'10" 163 lbs.
- Join Date
- May 2008
- Under Gods grace
- Rep Power
08-01-2009, 12:17 PM
I tried it before, it works well. I only noticed the tanning effects not any other effects such as libido, fat loss etc. You need exposure to the sun for it to work. The cost vs benefit isn't that great to me.
08-01-2009, 05:02 PM
08-02-2009, 09:31 AM
you could read more about it @ melanotan.org , its been a few years since I used it. Theres an issue of purity of the product I believe, some suppliers are better than others etc. and its not permanent. There seems to be an implant version but not sure how it works .
08-04-2009, 09:50 PM
Just ordered me some PT-141 for 'research' purposes
08-05-2009, 05:38 PM
I tried it and felt great libido wise but had to stop it on day 5 as I had crazy black moles popping up everywhere. Not worth it in my mind...
08-05-2009, 06:47 PM
08-06-2009, 07:25 PM
08-13-2009, 12:10 PM
- 5'11" 215 lbs.
- Join Date
- Aug 2007
- New Mexico
- Rep Power
I use it for the protective effect of UV absorption. After getting about 10 basal cells buzzed off my Irish hide over the past few years, I gave this a try. I haven't had any new basal cell growth since using a maintenance dose. (over about the past 2 years) It will work without any UV exposure, but you do get darker with UV.
08-13-2009, 12:32 PM
- 5'10" 205 lbs.
- Join Date
- Jun 2007
- Tampa, FL
- Rep Power
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