In estrogen receptor-positive breast cancer cells, resveratrol acted as an estrogen agonist in the absence of the endogenous estrogen, 17beta-estradiol, but acted as an estrogen antagonist in the presence of 17beta-estradiol (20, 21). At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens (17).
So how does that translate to resveratrol having negative effects on gyno caused by excessive estrogen?
Even when estrogen levels are halved under influence of "normal" AI administration resveratrol should have a positive influence on gyno?
When taking a strong AI like letrozole resulting in almost complete blocking of estrogen, say for 95% I can understand resveratrol having a negative effect then.
Do I get this right?
Thanks
So how does that translate to resveratrol having negative effects on gyno caused by excessive estrogen?
Even when estrogen levels are halved under influence of "normal" AI administration resveratrol should have a positive influence on gyno?
When taking a strong AI like letrozole resulting in almost complete blocking of estrogen, say for 95% I can understand resveratrol having a negative effect then.
Do I get this right?
Thanks